Results 121 to 130 of about 13,845,628 (330)

Complete Pathway Refactoring and Combinatorial Biosynthesis of Anthracyclines for Modulation of Histone Eviction and DNA Damage Bioactivities

open access: yesAngewandte Chemie, EarlyView.
A synthetic biology platform was established for the complete refactoring of complex anthracycline biosynthetic pathways in Streptomyces coelicolor using standardized, chemically synthetic DNA parts. This modular construction enabled streamlined combinatorial biosynthesis, yielding novel analogs that decouple DNA damage from chromatin damage (histone ...
Rongbin Wang   +15 more
wiley   +2 more sources

Present Role Of Phage Typing In Reliable Actinomycete Identification Schemes

open access: yes, 1996
Actinomycetes 1996, Volume 7 No. 1, pp 1-3 Present Role Of Phage Typing In Reliable Actinomycete Identification Schemes D. I. KURTBOKE Code Number: AC96006 Size of Files: Text: 15.5K No associated graphics files ABSTRACT.

core   +1 more source

PHAGE TYPING OF COAGULASE POSITIVE STAPHYLOCOCCI

open access: yesIranian Journal of Public Health, 1976
In determination of particular types of coagulate positive Staphylococci (Staphylococcus aurous) causing different diseases, especially hospital sepsis and food poisonings; 186 strains of coagulase positive Staphylococci from different provinces in Iran ...
T. Zirakzadeh   +2 more
doaj  

Characterization of Waterborne Outbreak–associated Campylobacter jejuni, Walkerton, Ontario

open access: yesEmerging Infectious Diseases, 2003
The Walkerton, Canada, waterborne outbreak of 2000 resulted from entry of Escherichia coli O157:H7 and Campylobacter spp. from neighboring farms into the town water supply.
Clifford G. Clark   +9 more
doaj   +1 more source

A new Vi-phage-type of Salmonella typhi and preparation of the typing phage.

open access: yesBulletin of the World Health Organization, 1968
A new Vi-phage-type of Salmonella typhi, type F(7), isolated in Poland in 1963, is described. The homologous typing phage was prepared from phage F(1). The new Vi-phage-type belongs to the F group and its "precursor" is type F(1). No temperate type-determining phage has so far been isolated from this phage-type.
J, Lalko, A, Gunnel
openaire   +1 more source

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

open access: yesAdvanced Science, EarlyView.
CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu   +8 more
wiley   +1 more source

Stabilizing Functional Nucleic Acids for Real‐Sample Diagnostics

open access: yesAngewandte Chemie, EarlyView.
Functional nucleic acids enable programmable real‐sample diagnostics, but often lose function in complex biological matrices. This review highlights four stabilization levers—chemical, topological, architectural, and microenvironment/interface engineering—that preserve aptamer and DNAzyme performance in saliva, serum, urine, and stool, reframing ...
Soyeon Lee   +4 more
wiley   +2 more sources

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

open access: yesAdvanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang   +4 more
wiley   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

open access: yesAngewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar   +2 more
wiley   +2 more sources

The role of lysogeny in the modification of phage typing patterns of Staphylococcus aureus isolated from dairy cows

open access: yes, 1980
Strains of Staphylococcus aureus were isolated at a single sampling from cows in a dairy herd. When typed by phage most showed a complex pattern of lysis with group III and IV phages.
Bradshaw E., Frost A.J.
core   +1 more source

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