Results 151 to 160 of about 22,820 (254)

Diet–Microbiome–Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications

Allergy, EarlyView.
ABSTRACT Mucosal surfaces are sites of highly dynamic interactions among epithelial and immune cells, environmental exposures, particularly dietary inputs, and the diverse microbial communities and their metabolites. These elements continually influence each other to maintain homeostasis and ensure appropriate immune discrimination between pathogens ...
Clara Delaroque, Liam O'Mahony, Inge Kortekaas Krohn, Charlotte G. Mortz, Markus Ollert, Mahesh S. Desai   +5 more
wiley   +1 more source

Host adaptation in <i>Salmonella enterica</i> serovar Typhimurium: population structure, pathovariants, and genomic mechanisms. [PDF]

Appl Environ Microbiol
Gong H, Wu Q, Xu M, Meng W, Wang Y, Ju C, Fu Y.   +6 more
europepmc   +1 more source

Evolving Approaches to Bacterial Identification: A Review of Classical and Modern Techniques. [PDF]

Int J Mol Sci
Gajic I, Jovicevic M, Kekic D, Kabic J, Vicic I, Lukovic B, Tomic A, Sovljanski O, Skoric M, Sikanic I, Jankovic M, Smitran A, Bozic L, Golic B, Basic J, Karabasil N, Opavski N.   +16 more
europepmc   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Synergistic effects of halo-plaque forming phage cocktails against polymicrobial <i>Acinetobacter baumannii</i> and <i>Staphylococcus aureus</i>. [PDF]

Microbiol Spectr
Naknaen A, Rueangrit A, Sudhikaran W, Chukamnerd A, Chumtong S, Chusri S, Pomwised R, Surachat K, Singkhamanan K, Ngasaman R.   +9 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Lineage-specific defence systems of pandemic <i>Vibrio cholerae</i>. [PDF]

Philos Trans R Soc Lond B Biol Sci
Blokesch M, Seed KD.
europepmc   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, EarlyView.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Whole-Genome Sequencing and Genomic Characterization of a Multi-Drug Resistant Phenotype of <i>Listeria monocytogenes</i> Isolated from Pet Food. [PDF]

Microorganisms
Mataragka A, Mataragas M, Tzimotoudis N, Galiatsatos I, Stathopoulou P, Paramithiotis S, Ikonomopoulos J, Andritsos ND.   +7 more
europepmc   +1 more source

Microbiome–Driven Carcinogenesis and Circulating Microbial Signals in Genitourinary Cancers

Cancer Science, EarlyView.
Experimental BBN models link gut microbial metabolism and diet‐microbiome interactions to urothelial carcinogenesis, while circulating extracellular vesicle‐associated bacterial DNA signals may reflect tumor immune contexture and immune checkpoint inhibitor outcomes in urothelial and renal cell carcinoma.
Atsunari Kawashima, Kentaro Jingushi, Takuro Saito, Toshihiro Uemura, Akinaru Yamamoto, Nesrine Sassi, Hiromu Horitani, Shunsuke Inoguchi, Yuki Horibe, Yu Ishizuya, Takuji Hayashi, Yoshiyuki Yamamoto, Norio Nonomura   +12 more
wiley   +1 more source