Toxin gene profiles, antibiotic resistance, and genetic diversity of <i>Clostridium perfringens</i> from food-producing animals: a whole-genome sequencing study with implications for food safety. [PDF]
Xie S +12 more
europepmc +1 more source
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao +7 more
wiley +1 more source
Resistance to clinically important antibiotics and reduced susceptibility to disinfectants in the pandemic ST398 methicillin-susceptible <i>Staphylococcus aureus</i> from Austria. [PDF]
Tóth AG, Makarova O.
europepmc +1 more source
Insights into the catalytic mechanism of formate dehydrogenases from different microbial sources
This integrated study combines experimental enzyme kinetics with QM/MM simulations to map the catalytic mechanisms of four formate dehydrogenases at the atomic level. This approach reveals the key determinants of catalytic efficiency and guides the rational design of biocatalysts for effective CO2 reduction—a crucial step towards sustainable ...
Laura Legnani +8 more
wiley +1 more source
Complete genome of a <i>Corynebacterium ulcerans</i> clinical isolate with two novel toxin gene alleles isolated from a leg ulcer. [PDF]
Bernier A-M +3 more
europepmc +1 more source
Transgenic selection and underlying mechanisms in apicomplexan parasites
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju +2 more
wiley +1 more source
Bacteriophages—viruses that kill bacteria—are promising weapons against bacterial biofilms: sessile communities notoriously resistant to antibiotics. Yet phages evolved not so much to eradicate bacteria as to obtain new bacteria to infect. That goal, however, may conflict with the physician's objective of complete bacterial clearance.
Stephen T. Abedon
wiley +1 more source
Earle K. Borman +11 more
openaire +2 more sources
The therapeutic potential of phage pT2784 against ST40-KL47 type <i>Acinetobacter baumannii</i> and bacterial fitness trade-offs. [PDF]
Zhou Z +6 more
europepmc +1 more source

