Results 181 to 190 of about 13,845,628 (330)

Typing class, 1967 -- 03

open access: yes, 1967
Junior Girls Technical School typing class ...
Swinburne Technical College
core  

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

open access: yesEpilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar   +4 more
wiley   +1 more source

A PD‐L1 Nanobody‐Engineered Synthetic RNA Virus Enhances Hepatocellular Carcinoma Immunotherapy by Interfering PCSK9 and Upregulating MHC‐I

open access: yesExploration, EarlyView.
A PD‐L1 nanobody‐engineered synthetic RNA virus (αPDL1‐VLPs/shPCSK9) is fabricated to inhibit PCSK9 and upregulate MHC‐I to facilitate T cells recognition of hepatocellular carcinoma (HCC). Moreover, αPDL1‐VLPs/shPCSK9 can recognize PD‐L1 and block the PD‐1/PD‐L1 pathway to prevent immune evasion, while promoting M2‐to‐M1 macrophages polarization ...
Chuyu Huang   +9 more
wiley   +1 more source

Engineered molecular diagnostic strategies for hepatocellular carcinoma: Integrating flexible photonic barcodes, liquid biopsies, and AI‐enhanced sensing platforms

open access: yesFlexMat, EarlyView.
Abstract Early diagnosis of hepatocellular carcinoma (HCC) remains challenging because conventional serum biomarkers, especially alpha‐fetoprotein (AFP), show limited sensitivity for early‐stage disease. Recent progress in engineered molecular diagnostics provides new opportunities to improve HCC detection through integrated material, molecular, and ...
Jingzhi Xue   +5 more
wiley   +1 more source

Receptor Structure Shapes Host Range but Incompletely Predicts High Activity in <i>Klebsiella pneumoniae</i> Phage Cocktails. [PDF]

open access: yesAntibiotics (Basel)
Gorodnichev RB   +8 more
europepmc   +1 more source

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