Results 191 to 200 of about 22,867 (253)

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Genomics of Irish swine-derived <i>Streptococcus suis</i>: population structure, prophages and anti-viral defence mechanisms. [PDF]

Microb Genom
Osei EK, O'Mahony AK, O'Hea R, Moriarty J, O'Doherty Á, Wilson M, Garcia Manzanilla E, Mahony J, Kenny JG.   +8 more
europepmc   +1 more source

A guide to the ecological limitations of phage therapy of bacterial biofilms: Is what's best for the phage best for the physician?

The FEBS Journal, EarlyView.
Bacteriophages—viruses that kill bacteria—are promising weapons against bacterial biofilms: sessile communities notoriously resistant to antibiotics. Yet phages evolved not so much to eradicate bacteria as to obtain new bacteria to infect. That goal, however, may conflict with the physician's objective of complete bacterial clearance.
Stephen T. Abedon
wiley   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

An ancient genome of Streptococcus pyogenes from a pre-Columbian Bolivian mummy. [PDF]

Nat Commun
Valverde G, Sarhan MS, Cook R, Rota-Stabelli O, Adriaenssens EM, Zink A, Maixner F.   +6 more
europepmc   +1 more source

Innovative Field Applications of Probiotics, Prebiotics, and Medicinal Plant Products for Disease Control in Aquaculture

Journal of Fish Diseases, EarlyView.
ABSTRACT Disease outbreaks and the associated reliance on antibiotics pose major constraints to the sustainability of modern aquaculture. As regulatory pressures increase and consumer demand shifts toward residue‐free production, diverse biological interventions are gaining prominence as viable alternatives to chemotherapeutics.
Mustafa Öz, Enes Üstüner, Sümmani Çifci, Suat Dikel, Emin İleri, Furkan Budak   +5 more
wiley   +1 more source

Impact of sequencing read quality on whole-genome sequencing outcomes for foodborne pathogens using a BacWORK standardized analysis workflow. [PDF]

Bioinform Adv
Felten A, Merda D, Vila Nova M, Touzain F, Chesnais V.   +4 more
europepmc   +1 more source

Enhanced exonuclease–Cas9 systems promote multiple nucleotide deletions with higher efficiency and broader targeting scope in plants

Journal of Integrative Plant Biology, EarlyView.
Cas9 preferentially generates small indels. By tethering an exonuclease and a DNA‐binding domain (DBD) to Cas9, the Exo‐DBD‐Cas9 system efficiently promotes multiple nucleotide deletions. These expanded deletions enable effective disruption of miRNA‐mediated regulation and relieve translational repression through targeted editing of 3′ untranslated ...
Rui Zhang, Xu Tang, Yao He, Wei Wang, Qiurong Ren, Yiping Qi, Yong Zhang   +6 more
wiley   +1 more source

Draft genome sequence of <i>Streptococcus gallolyticus</i> AAM02 isolated from traditional fermented milk in Bangladesh. [PDF]

Microbiol Resour Announc
Fakruddin M, Karim MAB, Chowdhury SA, Sultana A, Emon SZ, Bari ML, Al Mamun MA.   +6 more
europepmc   +1 more source

Revisiting the Genomic Epidemiology of Distinct Phage-Type <i>Vibrio cholerae</i> Strains Reveals Restricted Spatiotemporal Dissemination During an Epidemic. [PDF]

Microorganisms
Jiang Y, Zhao W, Yang X, Fan F, Li Z, Pang B, Kan B.   +6 more
europepmc   +1 more source