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Since time immemorial, phages—the viral parasites of bacteria—have been protecting Earth’s biosphere against bacterial overgrowth. Today, phages could help address the antibiotic resistance crisis that affects all of society. The greatest hurdle to the introduction of phage therapy in Western medicine is the lack of an appropriate legal and regulatory ...
Jean-Paul Pirnay +6 more
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Phage therapy refers to the use of bacteriophages (phages - bacterial viruses) as therapeutic agents against infectious bacterial diseases. This therapeutic approach emerged in the beginning of the 20th century but was progressively replaced by the use of antibiotics in most parts of the world after the second world war.
Joana Azeredo +6 more
openaire +2 more sources
Assessment of viral community functional potential from viral metagenomes may be hampered by contamination with cellular sequences [PDF]
Although the importance of viruses in natural ecosystems is widely acknowledged, the functional potential of viral communities is yet to be determined. Viral genomes are traditionally believed to carry only those genes that are directly pertinent to the ...
Simon Roux +4 more
doaj +1 more source
Dynamic Development of Viral and Bacterial Diversity during Grass Silage Preservation
Ensilaging is one of the most common feed preservation processes using lactic acid bacteria to stabilize feed and save feed quality. The silage bacterial community is well known but the role of the virome and its relationship with the bacterial community
Johan S. Sáenz +3 more
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Phage therapy is an exciting alternative to antibiotics. Why now?
openaire +2 more sources
Phages can be used successfully to treat pathogenic bacteria including zoonotic pathogens that colonize the intestines of animals and humans. However, low pH and digestive enzyme activity under harsh gastric conditions affect phage viability, thereby ...
Yuqiao Zhou +5 more
doaj +1 more source
Antimicrobial resistance (AMR) in bacteria is an important global health problem affecting humans, animals, and the environment. AMR is considered as one of the major components in the “global one health”.
Thandavarayan Ramamurthy +6 more
doaj +1 more source
Etude de la reconnaissance phage-bactérie : analyse fonctionnelle de l'adhésine gp38 des phages de la superfamille de type T4 [PDF]
Le spectre d'hôtes d'un phage est majoritairement déterminé par les adhésines phagiques. Leur reconnaissance spécifique des récepteurs situés à la surface bactérienne constitue la première étape de l'adsorption des phages. Dans la superfamille des phages
Trojet, Sabrina
core
454-Pyrosequencing: A Molecular Battiscope for Freshwater Viral Ecology [PDF]
Viruses, the most abundant biological entities on the planet, are capable of infecting organisms from all three branches of life, although the majority infect bacteria where the greatest degree of cellular diversity lies.
Allison, Heather E +23 more
core +1 more source
Bacteria- and Phage-Derived Proteins in Phage Infection
Phages have exerted severe evolutionary pressure on prokaryotes over billions of years, resulting in major rearrangements. Without every enzyme involved in the phage–bacterium interaction being examined; bacteriophages cannot be used in practical ...
Olga I. Guliy, Stella S. Evstigneeva
doaj +1 more source

