Results 111 to 120 of about 219,803 (412)

What makes gouty inflammation so variable? [PDF]

, 2017
Acute gout arthritis flares contribute dominantly to gout-specific impaired health-related quality of life, representing a progressively increasing public health problem.
Terkeltaub, Robert
core   +2 more sources

Spatiotemporal Transcriptomic Profiling Reveals the Dynamic Immunological Landscape of Alveolar Echinococcosis

Advanced Science, EarlyView.
An unprecedented high‐resolution spatial atlas of the E. multilocularis infection foci is obtained, revealing the dynamic functions of neutrophils, Spp1+ macrophages, and fibroblasts during disease progression. The transition of parasite control strategy from “active killing” to “negative segregation” by the host may provide instructive insights into ...
Zhihua Ou, Li Li, Peidi Ren, Ting‐Ting Zhou, Fan He, Jialing Chen, Huimin Cai, Xiumin Han, Yao‐Dong Wu, Jiandong Li, Xiu‐Rong Li, Qiming Tan, Wenhui Li, Qi Chen, Nian‐Zhang Zhang, Xiuju He, Wei‐Gang Chen, Yanping Zhao, Jiwen Sun, Qian Zhang, Yan‐Tao Wu, Yingan Liang, Jie You, Guohai Hu, Xue‐Qi Tian, Sha Liao, Bao‐Quan Fu, Ao Chen, Xue‐Peng Cai, Huanming Yang, Jian Wang, Xin Jin, Xun Xu, Wan‐Zhong Jia, Junhua Li, Hong‐Bin Yan   +35 more
wiley   +1 more source

Acid digestion and symbiont: Proton sharing at the origin of mitochondriogenesis?

BioEssays, Volume 45, Issue 1, January 2023., 2023
ADMit hypothesis for the origin of eukaryotes. A bacterial symbiont became associated with a protophagocytic host that captured prey with membrane processes. The symbiont cooperated to kill and digest the prey with reactive oxygen species and the acidification of the microenvironment.
Mario Mencía
wiley   +1 more source

Immunomodulatory effects of herbal plants plus melatonin on human blood phagocytes [PDF]

, 2011
It has been shown a mixture of seven herbal plants was able to trigger cell oxidative mechanism and subsequently inducing cellular activation. Moreover, melatonin hormone has also been shown to perform different actions on the cellular oxidative ...
Batalini, Claudemir, Correa, Valéria Conde, Ferrari, Carlos Kusano Bucalen, França, Eduardo Luzia, Honorio-França, Adenilda Cristina, Maynié, Joanna Conde, Pereira, Uender Correia Rodrigues   +6 more
core   +1 more source

Targeting Decidual CD16+ Immune Cells with Exosome‐Based Glucocorticoid Nanoparticles for Miscarriage

Advanced Science, EarlyView.
Exosome‐based nanoparticles (GC‐Exo‐CD16Ab) are designed to deliver glucocorticoids (GC) specifically to decidual CD16+ NK cells and macrophages. This targeted delivery effectively suppresses the cytotoxicity of decidual NK cells, inhibits M1 macrophage polarization, and modulates the decidual microenvironment.
Linlin Wang, Zhinang Yin, Yanqiong Shen, Gang Feng, Fangfang Dai, Dongyong Yang, Zhimin Deng, Jing Yang, Ruizhi Chen, Leifeng Yang, Xian Chen, Qing Sun, Chunyu Huang, Yanxiang Cheng, Hongbing Deng, Lianghui Diao, Longfei Li, Tailang Yin   +17 more
wiley   +1 more source

Targeting Frequent Efferocytosis in Tumor Microenvironment is a New Direction for Cancer Treatment

Small Science
A variety of factors, such as dietary habits, the external environment, and individual genetic differences, can lead to the development of cancer. While chemotherapy and radiotherapy are commonly used for cancer treatment, drug resistance and side ...
Gangxing Zhu, Xinliang Wan, Wanyin Wu, Luyu Jia, Xiaoyan Yu, Handan Mo, Xi Wang, Qichun Zhou, Qing Tang, Sumei Wang   +9 more
doaj   +1 more source

Both Granulocytic and Non-Granulocytic Blood Cells Are Affected in Patients with Severe Congenital Neutropenia and Their Non- Neutropenic Family Members: An Evaluation of Morphology, Function, and Cell Death

Turkish Journal of Hematology, 2018
Objective: To examine granulocytic and non-granulocytic cells in children with severe congenital neutropenia (SCN) and their nonneutropenic parents. Materials and Methods: Fifteen patients with SCN and 21 nonneutropenic parents were evaluated for a) CD95,
Lale Olcay, Şule Ünal, Hüseyin Onay, Esra Erdemli, Ayşenur Öztürk, Deniz Billur, Ayşe Metin, Hamza Okur, Yıldız Yıldırmak, Yahya Büyükaşık, Aydan İkincioğulları, Mesude Yılmaz Falay, Gülsüm Özet, Sevgi Yetgin   +13 more
doaj   +1 more source

Model of pathogenesis of psoriasis. Part 1. Systemic psoriatic process [PDF]

arXiv, 2011
Analytical study of results of experimental and theoretical works on pathogenesis of psoriatic disease was conducted. Psoriasis is dermal implication of systemic psoriatic process (SPP). New SPP model explaining results of clinical and laboratory experiments was formulated.
arxiv  

Candida albicans Hypha Formation and Mannan Masking of β-Glucan Inhibit Macrophage Phagosome Maturation [PDF]

, 2014
Received 28 August 2014 Accepted 28 October 2014 Published 2 December 2014 This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license. ACKNOWLEDGMENTS We thank Janet Willment, Aberdeen Fungal Group,
Bain, Judith M, Ballou, Elizabeth R., Brown, Alistair J. P., Brown, Gordon D., Erwig, Lars P., Gow, Neil A. R., Lewis, Leanne E., Louw, Johanna, Munro, Carol A., Okai, Blessing, Reid, Delyth, Walker, Louise A., Walls, Catriona A.   +12 more
core   +3 more sources

Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction

Advanced Science, EarlyView.
The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED‐ApoVs) in the treatment of CD8+ T cell‐mediated hypersensitivity reactions is noteworthy. SHED‐ApoVs are capable of fusing with the plasma membrane of CD8+ T cells, which subsequently triggers a series of events characterized by calcium overload ...
Anqi Liu, Peng Peng, Changze Wei, Fanhui Meng, Xiaoyao Huang, Peisheng Liu, Siyuan Fan, Xinyue Cai, Meiling Wu, Zilin Xuan, Qing Liu, Xinyu Qiu, Zhenlai Zhu, Hao Guo   +13 more
wiley   +1 more source