Results 91 to 100 of about 91,899 (296)

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

Clusters of phagocytes are present in cultures after 1 hr.

, 2013
Phagocytes are labeled for actin (green, A), Sp185/333 (red, B) and DNA (blue, C). Merged images are shown in D and E. Arrows in A indicate the direction of the actin cables for polygonal phagocytes labeled 1 and 2.
Christopher J. Bayne (157584), Audrey J. Majeske (403355), L. Courtney Smith (403356)   +2 more
core   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Evidence that inhibition of phorbol ester-induced superoxide anion formation by cyclosporin A in phagocytes is not mediated by direct inhibition of protein kinase C [PDF]

, 1994
Cyclosporin A (CsA) has been reported to inhibit phorbol myristate acetate (PMA)-induced superoxide anion (O2-) formation in human neutrophils and murine macrophages.
Grünbaum, L., Hummel, R., Schächtele, C., Wenzel-Seifert, K., Seifert, Roland   +4 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Mononuclear phagocytes of the intestine, the skin, and the lung

, 2014
Tissues that are in direct contact with the outside world face particular immunological challenges. The intestine, the skin, and the lung possess important mononuclear phagocyte populations to deal with these challenges, but the cellular origin of these ...
Scott, Charlotte, Martin Guilliams, Charlotte L. Scott, Guilliams, Martin, Sandrine Henri, Henri, Sandrine   +5 more
core   +1 more source

Targeting mononuclear phagocytes for eradicating intracellular parasites [PDF]

, 2017
Mononuclear phagocytes such as monocytes, tissue-specific macrophages and dendritic cells are primary actors in both innate and adaptive immunity, as well as tissue homoeostasis. They have key roles in a range of physiological and pathological processes,
Simon J. Foster, James D. Robertson, Robertson, James D., Simon Yona, De Geest, Bruno, Tomasz K. Prajsnar, Philip M. Elks, McHugh, Timothy, Canseco, Julio Ortiz, De Koker, Stefaan, David H. Dockrell, Daneshpour, Nooshin, Alessandro Poma, Renshaw, Stephen A., Bruno De Geest, Poma, Alessandro, Stefaan De Koker, Evangelopoulos, Dimitrios, Yona, Simon, Dockrell, David H., Nooshin Daneshpour, Timothy McHugh, Marriott, Helen M., Rizzello, Loris, Prajsnar, Tomasz K., Loris Rizzello, Julio Ortiz Canseco, Elks, Philip M., Giuseppe Battaglia, Dimitrios Evangelopoulos, Stephen A. Renshaw, Helen M. Marriott, Foster, Simon J., Battaglia, Giuseppe   +33 more
core   +1 more source

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

The trajectory and characteristics of mononuclear phagocytes’ differentiation into macrophages.

(A). Pseudotime plot showed the dynamics of mononuclear phagocytes. (B). Pseudotime plot of mononuclear phagocytes showed stages of each cluster. (C). Developmental trajectory of mononuclear phagocytes inferred by RNA velocity.
Jinyun Chen (264711), Shaobo Tian (18056542), Tiantian Ji (12540934), Zheng Wang (25883), Haoyu Fu (1826338), Guobin Wang (322861), Lin Wang (11986), Liping Wang (33601)   +7 more
core   +1 more source