Results 91 to 100 of about 140,162 (306)
Медицинская иммунология, 2014 . The article considers an original approach to individual dose selection and efficiency evaluation of immunity-targeted drugs applied for treatment of children with trauma, based on examination of phagocyte locomotive functions.
O. N. Zlakomanova +2 more
doaj +1 more source
Advanced Science, EarlyView.Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu +13 more
wiley +1 more source
Degradation of connective tissue matrices by macrophages. III. Morphological and biochemical studies on extracellular, pericellular, and intracellular events in matrix proteolysis by macrophages in culture. [PDF]
, 1980 We have shown that macrophages in culture degrade the glycoproteins and amorphous elastin of insoluble extracellular matrices. Ultrastructural observation of the macrophage-matrix interaction revealed that connective tissue macromolecules were ...
Bainton, DF, Jones, PA, Werb, Z
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LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1
Advanced Science, EarlyView.LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li +12 more
wiley +1 more source
Kuhn on discovery and the case of Penicillin [PDF]
, 2006 Book description: Nowadays, philosophy and methodology of science appear as a combination of novelty and continuity. This blend is clear both in the general approaches to science (those thought of as any science) and in the specific perspectives on ...
Gillies, D.
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Advanced Science, EarlyView.CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He +17 more
wiley +1 more source
Modulation of apoprotein E secretion in response to receptor-mediated endocytosis in resident and inflammatory macrophages. [PDF]
, 1984 We have determined the effect of various endocytic ligands on the secretion of ApoE by macrophages. ApoE was a major secreted protein of resident macrophages, but BCG-activated macrophages secreted little ApoE and periodate-elicited macrophages secreted ...
Takemura, R, Werb, Z
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Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Antibody-Dependent Cellular Phagocytosis in Antiviral Immune Responses
Frontiers in Immunology, 2019 Antiviral activities of antibodies may either be dependent only on interactions between the antibody and cognate antigen, as in binding and neutralization of an infectious virion, or instead may require interactions between antibody–antigen immune ...
Matthew Zirui Tay +3 more
doaj +1 more source
Az Interferon-gamma által indukált jelátvitel mechanizmusa humán újszülöttek mononukleáris fagocitasejtjeiben = Interferon-gamma induced signaling in mononuclear phagocytes from human neonates [PDF]
, 2006 Humán újszülöttek és felnőttek mononukleáris (MN) fagocitasejtjeiben a foszforilált STAT-1 kimutatásához olyan monoclonalis antitesteket használtunk, amelyek specifikusan kötődnek a foszforilált STAT-1 molekulákhoz, de nem kötődnek a natív STAT-1 ...
Erdős, Melinda +4 more
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