Results 111 to 120 of about 91,899 (296)

Immunomodulatory effects of herbal plants plus melatonin on human blood phagocytes [PDF]

, 2010
It has been shown a mixture of seven herbal plants was able to trigger cell oxidative mechanism and subsequently inducing cellular activation. Moreover, melatonin hormone has also been shown to perform different actions on the cellular oxidative ...
Joanna Conde Maynié, Valéria Conde Correa, Adenilda Cristina Honorio-França, Carlos Kusano Bucalen Ferrari, Uender Correia Rodrigues Pereira, Eduardo Luzia França, Claudemir Batalini   +6 more
core   +1 more source

Fate of Tunic Phagocytes in the Colonial Ascidian Aplidium yamazii [PDF]

In the tunic of the colonial ascidian Aplidium yamazii, tunic phagocytes, the only phagocytic cell type, are ameboid and highly motile. In this study, we traced the fate of tunic phagocytes that were labeled with fluorescent beads following endocytosis ...
ISHII, Teruhisa, 広瀬, 裕一, HIROSE, Euichi, 石井, 照久   +3 more
core   +1 more source

THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome

Advanced Science, EarlyView.
The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong, Qize Xue, Xiaoan Wei, Jie Li, Bao Huang, Weishao Chen, Zimin Cai, Tao Yang, Chengjun Yao, Jiayan Jin, Bohan Cai, Xuyang Zhang, Junhui Liu, Haihao Wu, Jian Chen, Zhi Shan, Fengdong Zhao   +16 more
wiley   +1 more source

Targeted Delivery of Indole‐3‐Pyruvic Acid Suppresses Macrophage Ferroptosis to Enhance CD8+ T Cell‐Mediated Immunotherapy Response in Bladder Cancer

Advanced Science, EarlyView.
A microbiota‐derived metabolite, indole‐3‐pyruvic acid, suppresses macrophage ferroptosis through the AHR–NF‐κB–SLC7A11 axis. This preserves CD8+ T cell function in bladder cancer. Macrophage‐targeted nanoparticles enhance indole‐3‐pyruvic acid delivery and overcome resistance to PD‐1 blockade.
Jianwen Lao, Xinhao Yuan, Shuai Liang, Kai Deng, Daqin Wu, Longhao Xu, Kun Zheng, Yi Lin, Peicong Cai, Haoran Zheng, Junyu Chen, Mingli Luo, Yan Chen, Xiong Chen, Chunhui Wang, Wenlong Zhong   +15 more
wiley   +1 more source

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source

Identification of an Osteochondral Erosion Process in Gout Driven by Fibrinogen‐Integrin Activation and Local MSU Crystallization

Advanced Science, EarlyView.
Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu, Simin Bi, Zhechen Liu, Xiaofeng Zhou, Hengwei Qin, Nicola Dalbeth, Minbiao Ji, Yinghui Hua   +7 more
wiley   +1 more source

A Pancreatitis‐Inspired Trypsinogen Nanoplatform Reprograms Tumor‐Associated Macrophages via NF‐κB for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
Trypsinogen‐loaded nanoparticles reprogram TAMs via NF‐κB/NLRP3, driving M2→M1 conversion and potent phagocytosis to unleash antitumor immunity. ABSTRACT Although reprogramming tumor‐associated macrophages (TAMs) represents a promising therapeutic strategy, approaches that are both precise and safe remain scarce.
Lei Cao, Yu He, Wenhao Li, Bo Gong, Han Lin, Jianlin Shi, Yuan Yong, Wencheng Wu   +7 more
wiley   +1 more source

Immunomodulatory effects of herbal plants plus melatonin on human blood phagocytes [PDF]

, 2011
It has been shown a mixture of seven herbal plants was able to trigger cell oxidative mechanism and subsequently inducing cellular activation. Moreover, melatonin hormone has also been shown to perform different actions on the cellular oxidative ...
Batalini, Claudemir; Federal University of Mato Grosso Pontal do Araguaia – MT, Brazil, Ferrari, Carlos Kusano Bucalen; Institute of Biological and Health Science - Federal University of Mato Grosso – Pontal do Araguaia – MT, Brazil. - Rodovia MT 100, Km 3,5 s/no, Pontal do Araguaia - MT. CEP:78698-000, Correa, Valéria Conde; Environmental Biodiversity Center EcoCerrado Reserve, Araxá, MG-Brazil., França, Eduardo Luzia; Institute of Biological and Health Science - Federal University of Mato Grosso – Pontal do Araguaia – MT, Brazil. - Rodovia MT 100, Km 3,5 s/no, Pontal do Araguaia - MT. CEP:78698-000, Honorio-França, Adenilda Cristina; Institute of Biological and Health Science - Federal University of Mato Grosso – Pontal do Araguaia – MT, Brazil. - Rodovia MT 100, Km 3,5 s/no, Pontal do Araguaia - MT. CEP:78698-000, Maynié, Joanna Conde; Environmental Biodiversity Center EcoCerrado Reserve, Araxá, MG-Brazil., Pereira, Uender Correia Rodrigues; Institute of Biological and Health Science - Federal University of Mato Grosso – Pontal do Araguaia – MT, Brazil. - Rodovia MT 100, Km 3,5 s/no, Pontal do Araguaia - MT. CEP:78698-000   +6 more
core  

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source