Results 11 to 20 of about 396,432 (395)
Glia, 2022 In human demyelinating diseases such as multiple sclerosis (MS), an imbalance between demyelination and remyelination can trigger progressive degenerative processes.
M. K. Sen +3 more
semanticscholar +1 more source
Current Biology, 2011 SummaryPhagocytosis is defined as the receptor-mediated engulfment of large (≥0.5 μm) particles into plasma membrane-derived vacuoles called phagosomes. Following scission from the plasma membrane, the phagosomes undergo a maturation process, sequentially fusing with endosomes and lysosomes, ultimately becoming phagolysosomes — highly acidic and ...
Botelho, Roberto J., Grinstein, Sergio
openaire +2 more sources
Transcriptional signature in microglia associated with Aβ plaque phagocytosis
Nature Communications, 2021 The role of microglia cells in Alzheimer’s disease (AD) is well recognized, however their molecular and functional diversity remain unclear. Here, we isolated amyloid plaque-containing (using labelling with methoxy-XO4, XO4+) and non-containing (XO4 ...
Alexandra Grubman +27 more
semanticscholar +1 more source
Frontiers in Microbiology, 2022 Macrophages play a central role in the innate immune response to respiratory viral infections through pro-inflammatory factor secretion and phagocytosis.
Naoko Morita +6 more
doaj +1 more source
Microglial phagocytosis of neurons in neurodegeneration, and its regulation
Journal of Neurochemistry, 2021 There is growing evidence that excessive microglial phagocytosis of neurons and synapses contributes to multiple brain pathologies. RNA‐seq and genome‐wide association (GWAS) studies have linked multiple phagocytic genes to neurodegenerative diseases ...
C. Butler +5 more
semanticscholar +1 more source
Succinate Promotes Phagocytosis of Monocytes/Macrophages in Teleost Fish
Frontiers in Molecular Biosciences, 2021 Development of immunity-based strategy to manage bacterial infection is urgently needed in aquaculture due to the widespread of antibiotic-resistant bacteria.
Dai-xiao Yang +15 more
doaj +1 more source
Cell Death and Differentiation, 2021 During cancer therapy, phagocytic clearance of dead cells plays a vital role in immune homeostasis. The nonapoptotic form of cell death, ferroptosis, exhibits extraordinary potential in tumor treatment.
Xiang Luo +12 more
semanticscholar +1 more source
Frontiers in Immunology, 2023 Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a serious bleeding condition mostly caused by the reaction between maternal anti-HPA-1a antibodies and fetal platelets. This reaction leads to Fc-dependent platelet phagocytosis.
Paula Ames +11 more
doaj +1 more source
A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022 Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls +9 more
wiley +1 more source
Regulators of phagocytosis as pharmacologic targets for stroke treatment
Frontiers in Pharmacology, 2023 Stroke, including ischemic and hemorrhagic stroke, causes massive cell death in the brain, which is followed by secondary inflammatory injury initiated by disease-associated molecular patterns released from dead cells. Phagocytosis, a cellular process of
Jian Cheng +6 more
doaj +1 more source