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Phagocytosis: Our Current Understanding of a Universal Biological Process
Frontiers in Immunology, 2020 Phagocytosis is a cellular process for ingesting and eliminating particles larger than 0.5 μm in diameter, including microorganisms, foreign substances, and apoptotic cells.
Eileen Uribe-Querol, Carlos Rosales
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Phagocytosis in the Brain: Homeostasis and Disease
Frontiers in Immunology, 2019 Microglia are resident macrophages of the central nervous system and significantly contribute to overall brain function by participating in phagocytosis during development, homeostasis, and diseased states.
Dylan A. Galloway +3 more
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Antibody-Dependent Cellular Phagocytosis in Antiviral Immune Responses [PDF]
Frontiers in Immunology, 2019 Antiviral activities of antibodies may either be dependent only on interactions between the antibody and cognate antigen, as in binding and neutralization of an infectious virion, or instead may require interactions between antibody–antigen immune ...
Matthew Zirui Tay +2 more
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Glia, 2022 In human demyelinating diseases such as multiple sclerosis (MS), an imbalance between demyelination and remyelination can trigger progressive degenerative processes.
M. K. Sen +3 more
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Transcriptional signature in microglia associated with Aβ plaque phagocytosis
Nature Communications, 2021 The role of microglia cells in Alzheimer’s disease (AD) is well recognized, however their molecular and functional diversity remain unclear. Here, we isolated amyloid plaque-containing (using labelling with methoxy-XO4, XO4+) and non-containing (XO4 ...
Alexandra Grubman +27 more
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Microglial phagocytosis of neurons in neurodegeneration, and its regulation
Journal of Neurochemistry, 2021 There is growing evidence that excessive microglial phagocytosis of neurons and synapses contributes to multiple brain pathologies. RNA‐seq and genome‐wide association (GWAS) studies have linked multiple phagocytic genes to neurodegenerative diseases ...
C. Butler +5 more
semanticscholar +1 more source
Cell Death and Differentiation, 2021 During cancer therapy, phagocytic clearance of dead cells plays a vital role in immune homeostasis. The nonapoptotic form of cell death, ferroptosis, exhibits extraordinary potential in tumor treatment.
Xiang Luo +12 more
semanticscholar +1 more source
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionKlebsiella pneumoniae (Kp) is a common cause of hospital-acquired pneumonia. Although previous studies have suggested that evasion of phagocytic uptake is a virulence determinant of Kp, few studies have examined phagocytosis sensitivity in ...
Rick van der Geest +19 more
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Frontiers in Immunology, 2020 Macrophages are professional phagocytes that are uniquely situated between the innate and adaptive arms of immunity with a high capacity for phagocytosis and proinflammatory cytokine production as well as antigen presentation.
Durga Acharya +3 more
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Impaired clearance of early apoptotic cells mediated by inhibitory IgG antibodies in patients with primary Sjögren's syndrome. [PDF]
PLoS ONE, 2014 OBJECTIVES: Deficient efferocytosis (i.e. phagocytic clearance of apoptotic cells) has been frequently reported in systemic lupus erythematosus (SLE).
Menelaos N Manoussakis +3 more
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