Results 11 to 20 of about 435,809 (335)

Transcriptional signature in microglia associated with Aβ plaque phagocytosis

open access: yesNature Communications, 2021
The role of microglia cells in Alzheimer’s disease (AD) is well recognized, however their molecular and functional diversity remain unclear. Here, we isolated amyloid plaque-containing (using labelling with methoxy-XO4, XO4+) and non-containing (XO4 ...
Alexandra Grubman   +27 more
semanticscholar   +1 more source

Succinate Promotes Phagocytosis of Monocytes/Macrophages in Teleost Fish

open access: yesFrontiers in Molecular Biosciences, 2021
Development of immunity-based strategy to manage bacterial infection is urgently needed in aquaculture due to the widespread of antibiotic-resistant bacteria.
Dai-xiao Yang   +15 more
doaj   +1 more source

Microglial phagocytosis of neurons in neurodegeneration, and its regulation

open access: yesJournal of Neurochemistry, 2021
There is growing evidence that excessive microglial phagocytosis of neurons and synapses contributes to multiple brain pathologies. RNA‐seq and genome‐wide association (GWAS) studies have linked multiple phagocytic genes to neurodegenerative diseases ...
C. Butler   +5 more
semanticscholar   +1 more source

Regulators of phagocytosis as pharmacologic targets for stroke treatment

open access: yesFrontiers in Pharmacology, 2023
Stroke, including ischemic and hemorrhagic stroke, causes massive cell death in the brain, which is followed by secondary inflammatory injury initiated by disease-associated molecular patterns released from dead cells. Phagocytosis, a cellular process of
Jian Cheng   +6 more
doaj   +1 more source

The roles of microglia and astrocytes in phagocytosis and myelination: Insights from the cuprizone model of multiple sclerosis

open access: yesGlia, 2022
In human demyelinating diseases such as multiple sclerosis (MS), an imbalance between demyelination and remyelination can trigger progressive degenerative processes.
M. K. Sen   +3 more
semanticscholar   +1 more source

The cytoskeleton in phagocytosis and macropinocytosis.

open access: yesCurrent Biology, 2021
Cells of the innate immune system, notably macrophages, neutrophils and dendritic cells, perform essential antimicrobial and homeostatic functions.
S. Mylvaganam, S. Freeman, S. Grinstein
semanticscholar   +1 more source

Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2

open access: yesCell Death and Differentiation, 2021
During cancer therapy, phagocytic clearance of dead cells plays a vital role in immune homeostasis. The nonapoptotic form of cell death, ferroptosis, exhibits extraordinary potential in tumor treatment.
Xiang Luo   +12 more
semanticscholar   +1 more source

A genome-wide CRISPR/Cas9 screen to identify phagocytosis modulators in monocytic THP-1 cells

open access: yesScientific Reports, 2021
Phagocytosis of microbial pathogens, dying or dead cells, and cell debris is essential to maintain tissue homeostasis. Impairment of these processes is associated with autoimmunity, developmental defects and toxic protein accumulation.
Benjamin Lindner   +6 more
doaj   +1 more source

In vitro analysis of anti-HPA-1a dependent platelet phagocytosis and its inhibition using a new whole blood phagocytosis assay (WHOPPA)

open access: yesFrontiers in Immunology, 2023
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a serious bleeding condition mostly caused by the reaction between maternal anti-HPA-1a antibodies and fetal platelets. This reaction leads to Fc-dependent platelet phagocytosis.
Paula Ames   +11 more
doaj   +1 more source

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