Results 11 to 20 of about 420,323 (395)
Target shape dependence in a simple model of receptor-mediated endocytosis and phagocytosis [PDF]
Proc Natl Acad Sci USA 113(22):6113-6118 (2016), 2016 Phagocytosis and receptor-mediated endocytosis are vitally important particle uptake mechanisms in many cell types, ranging from single-cell organisms to immune cells. In both processes, engulfment by the cell depends critically on both particle shape and orientation.
Endres, Robert G., Richards, David M.
arxiv +5 more sources
Phagocytosis: Our Current Understanding of a Universal Biological Process
Frontiers in Immunology, 2020 Phagocytosis is a cellular process for ingesting and eliminating particles larger than 0.5 μm in diameter, including microorganisms, foreign substances, and apoptotic cells.
Eileen Uribe-Querol, Carlos Rosales
doaj +2 more sources
The zipper mechanism in phagocytosis: energetic requirements and variability in phagocytic cup shape [PDF]
arXiv, 2010 Phagocytosis is the fundamental cellular process by which eukaryotic cells bind and engulf particles by their cell membrane. Particle engulfment involves particle recognition by cell-surface receptors, signaling and remodeling of the actin cytoskeleton to guide the membrane around the particle in a zipper-like fashion. Despite the signaling complexity,
Dart, Anna E. +3 more
arxiv +7 more sources
Phagocytosis: An Immunobiologic Process [PDF]
Immunity, 2016 It has been a century since the death of Élie Metchnikoff, who championed the role of phagocytosis in cellular immunity. Whereas others had observed the uptake of particles by cells from simple to complex organisms, he grasped its significance in the host response to injury and infection and established a firm basis for our understanding of ...
S. Gordon
openaire +5 more sources
Phagocytosis in the Brain: Homeostasis and Disease
Frontiers in Immunology, 2019 Microglia are resident macrophages of the central nervous system and significantly contribute to overall brain function by participating in phagocytosis during development, homeostasis, and diseased states.
Dylan A. Galloway +3 more
doaj +2 more sources
Measurement of macrophage phagocytic capacity by quantifying maximum membrane extension using an opsonized capillary tube assay [PDF]
Scientific ReportsThe zipper mechanism explains phagocytosis as sequential ligand–receptor interactions between macrophages and antigens, followed by the cell membrane extension for phagosome formation. Hence, the ability of macrophages to innate immunity is restricted by
Dan Horonushi +4 more
doaj +2 more sources
Emerging phagocytosis checkpoints in cancer immunotherapy
Signal Transduction and Targeted Therapy, 2023 Cancer immunotherapy, mainly including immune checkpoints-targeted therapy and the adoptive transfer of engineered immune cells, has revolutionized the oncology landscape as it utilizes patients’ own immune systems in combating the cancer cells.
Yue-Ying Liu +9 more
semanticscholar +1 more source