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Current Biology, 2011 SummaryPhagocytosis is defined as the receptor-mediated engulfment of large (≥0.5 μm) particles into plasma membrane-derived vacuoles called phagosomes. Following scission from the plasma membrane, the phagosomes undergo a maturation process, sequentially fusing with endosomes and lysosomes, ultimately becoming phagolysosomes — highly acidic and ...
Botelho, Roberto J., Grinstein, Sergio
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Frontiers in Microbiology, 2022 Macrophages play a central role in the innate immune response to respiratory viral infections through pro-inflammatory factor secretion and phagocytosis.
Naoko Morita +6 more
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Frontiers in Cellular and Infection Microbiology, 2023 IntroductionKlebsiella pneumoniae (Kp) is a common cause of hospital-acquired pneumonia. Although previous studies have suggested that evasion of phagocytic uptake is a virulence determinant of Kp, few studies have examined phagocytosis sensitivity in ...
Rick van der Geest +19 more
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Frontiers in Immunology, 2020 Macrophages are professional phagocytes that are uniquely situated between the innate and adaptive arms of immunity with a high capacity for phagocytosis and proinflammatory cytokine production as well as antigen presentation.
Durga Acharya +3 more
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Impaired clearance of early apoptotic cells mediated by inhibitory IgG antibodies in patients with primary Sjögren's syndrome. [PDF]
PLoS ONE, 2014 OBJECTIVES: Deficient efferocytosis (i.e. phagocytic clearance of apoptotic cells) has been frequently reported in systemic lupus erythematosus (SLE).
Menelaos N Manoussakis +3 more
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Phosphoinositides and phagocytosis [PDF]
The Journal of Cell Biology, 2001 Phosphoinositide 3 kinases (PI3Ks)**Abbreviation used in this paper: PI3K, phosphoinositide 3 kinase. are known as regulators of phagocytosis. Recent results demonstrate that class I and III PI3Ks act consecutively in phagosome formation and maturation, and that their respective products, phosphatidylinositol 3,4,5-trisphosphate (PI[3,4,5]P3) and ...
David J. Gillooly +2 more
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Frontiers in Immunology, 2021 Fc receptor (FcR) is an important opsonin receptor on the surface of immune cells, playing an important role in antibody-dependent cell-mediated immunity.
Yanbo Hao +8 more
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