Results 21 to 30 of about 396,432 (395)

Coxiella burnetii Phagocytosis Is Regulated by GTPases of the Rho Family and the RhoA Effectors mDia1 and ROCK [PDF]

, 2015
The GTPases belonging to the Rho family control the actin cytoskeleton rearrangements needed for particle internalization during phagocytosis. ROCK and mDia1 are downstream effectors of RhoA, a GTPase involved in that process.
A Alonso, A Schonichen, A Subtil, A Tierrez, A Yoneda, AB Hall, AB Jaffe, AD Hoppe, AL Bishop, AP Wheeler, AR Frampton Jr., AS Alberts, B Qualmann, BJ Wallar, C Capo, C Cougoule, C Yang, CA Burnham, CM Haglund, CW Gourlay, D Howe, D Michaelson, D Michaelson, D Truong, Daniel E. Voth, DE Voth, DJ Hackam, DM Underhill, DM Waag, DT Brandt, E Alix, E Caron, E Colucci-Guyon, E Lemichez, EJ van Schaik, EM Rosales, EN Firat-Karalar, F Li, F Matsumura, F Niedergang, G Kaplan, GD Fairn, H Bierne, H Bierne, H Genth, HJ Newton, IM Olazabal, J Dellacasagrande, J Faix, J Hanisch, J Pizarro-Cerda, J Pizarro-Cerda, JA McDonough, JA Swanson, JC Patel, JC Patel, JE Heindl, Jesús S. Distel, JG Duman, JG Kim, K Aktories, K Bhadriraju, L Hodgson, LA Allen, M Aguilera, M Amano, M Amano, M Fernandez-Borja, M Kaksonen, M Ladwein, María I. Colombo, MG Gutierrez, Milton O. Aguilera, ML Gardel, N Ramalingam, N Watanabe, N Watanabe, NA Khan, O Billker, O Pertz, O Pertz, OB Matas, OG Baca, OG Baca, P Aspenstrom, P Cossart, P Croise, P Hotulainen, PJ Roberts, PS Romano, R Fox, RA Carabeo, RC May, RC May, Rodolfo M. Ortiz Flores, Romina P. Salinas, RS Flannagan, S Meconi, SJ Heasman, SK Hussain, T Dubois, T Tominaga, V Benard, VC Tam, W Beron, Walter Berón, WI Goh, X Chi, XD Ren, Z Woldehiwet   +109 more
core   +21 more sources

A genome-wide CRISPR/Cas9 screen to identify phagocytosis modulators in monocytic THP-1 cells

Scientific Reports, 2021
Phagocytosis of microbial pathogens, dying or dead cells, and cell debris is essential to maintain tissue homeostasis. Impairment of these processes is associated with autoimmunity, developmental defects and toxic protein accumulation.
Benjamin Lindner, Eva Martin, Monika Steininger, Aleksandra Bundalo, Martin Lenter, Johannes Zuber, Michael Schuler   +6 more
doaj   +1 more source

Complement Receptor-Mediated Phagocytosis Induces Proinflammatory Cytokine Production in Murine Macrophages

Frontiers in Immunology, 2020
Macrophages are professional phagocytes that are uniquely situated between the innate and adaptive arms of immunity with a high capacity for phagocytosis and proinflammatory cytokine production as well as antigen presentation.
Durga Acharya, Xiao Rui (Lisa) Li, Rebecca Emily-Sue Heineman, Rene E. Harrison   +3 more
doaj   +1 more source

Impaired clearance of early apoptotic cells mediated by inhibitory IgG antibodies in patients with primary Sjögren's syndrome. [PDF]

PLoS ONE, 2014
OBJECTIVES: Deficient efferocytosis (i.e. phagocytic clearance of apoptotic cells) has been frequently reported in systemic lupus erythematosus (SLE).
Menelaos N Manoussakis, George E Fragoulis, Aigli G Vakrakou, Haralampos M Moutsopoulos   +3 more
doaj   +1 more source

Phagocytosis is a primary determinant of pulmonary clearance of clinical Klebsiella pneumoniae isolates

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionKlebsiella pneumoniae (Kp) is a common cause of hospital-acquired pneumonia. Although previous studies have suggested that evasion of phagocytic uptake is a virulence determinant of Kp, few studies have examined phagocytosis sensitivity in ...
Rick van der Geest, Hongye Fan, Hernán F. Peñaloza, William G. Bain, William G. Bain, Zeyu Xiong, Naina Kohli, Emily Larson, Mara L. G. Sullivan, Jonathan M. Franks, Donna B. Stolz, Ryota Ito, Kong Chen, Yohei Doi, Yohei Doi, Melanie J. Harriff, Melanie J. Harriff, Janet S. Lee, Janet S. Lee, Janet S. Lee   +19 more
doaj   +1 more source

Phosphoinositides and phagocytosis [PDF]

The Journal of Cell Biology, 2001
Phosphoinositide 3 kinases (PI3Ks)**Abbreviation used in this paper: PI3K, phosphoinositide 3 kinase. are known as regulators of phagocytosis. Recent results demonstrate that class I and III PI3Ks act consecutively in phagosome formation and maturation, and that their respective products, phosphatidylinositol 3,4,5-trisphosphate (PI[3,4,5]P3) and ...
David J. Gillooly, Anne Simonsen, Harald Stenmark   +2 more
openaire   +3 more sources

Phagocytosis of microparticles increases responsiveness of macrophage-like cell lines U937 and THP-1 to bacterial lipopolysaccharide and lipopeptide

Scientific Reports, 2021
Following bacterial infection, macrophages produce pro-inflammatory cytokines in response to bacterial cell components, including lipopolysaccharide (LPS) and lipopeptide, and simultaneously phagocytize and digest the invading bacteria.
Takayuki Ueno, Yumi Yamamoto, Kiyoshi Kawasaki   +2 more
doaj   +1 more source

Phagocytosis [PDF]

Immunity, 2005
Phagocytosis requires receptor-mediated recognition of particles, usually in the guise of infectious agents and apoptotic cells. Phagosomes fuse with lysosomes to generate phagolysosomes, which play a key role in enzymatic digestion of the internalized contents into component parts.
Lynda M. Stuart, Lynda M. Stuart, R. Alan B. Ezekowitz   +2 more
openaire   +3 more sources

Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome

Journal of Neuroscience, 2020
During adult hippocampal neurogenesis, most newborn cells undergo apoptosis and are rapidly phagocytosed by resident microglia to prevent the spillover of intracellular contents. Here, we propose that phagocytosis is not merely passive corpse removal but
Irune Díaz-Aparicio, Iñaki Paris, Virginia Sierra-Torre, Ainhoa Plaza-Zabala, Noelia Rodriguez-Iglesias, Mar Márquez-Ropero, S. Beccari, Paloma Huguet, Oihane Abiega, E. Alberdi, C. Matute, Irantzu Bernales, A. Schulz, Lilla Otrokocsi, B. Sperlágh, Kaisa E Happonen, G. Lemke, M. Maletić-Savatić, J. Valero, A. Sierra   +19 more
semanticscholar   +1 more source

Decreased neutrophil bactericidal activity during phagocytosis of a slime-producing Staphylococcus aureus strain. [PDF]

, 2000
Phagocytosis and intracellular killing by bovine polymorphonuclear leukocytes (PMN) are important host defence mechanisms against mastitis caused by Staphylococcus aureus. We compared the phagocytosis and overall killing of a non slime-producing (NSP) S.
Barrio, Belén, Burvenich, Christian, Dosogne, Hilde, Vangroenweghe, Frédéric   +3 more
core   +3 more sources