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Phagocytosis [PDF]

Current Biology, 2011
SummaryPhagocytosis is defined as the receptor-mediated engulfment of large (≥0.5 μm) particles into plasma membrane-derived vacuoles called phagosomes. Following scission from the plasma membrane, the phagosomes undergo a maturation process, sequentially fusing with endosomes and lysosomes, ultimately becoming phagolysosomes — highly acidic and ...
Botelho, Roberto J., Grinstein, Sergio
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Phagocytosis is a primary determinant of pulmonary clearance of clinical Klebsiella pneumoniae isolates

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionKlebsiella pneumoniae (Kp) is a common cause of hospital-acquired pneumonia. Although previous studies have suggested that evasion of phagocytic uptake is a virulence determinant of Kp, few studies have examined phagocytosis sensitivity in ...
Rick van der Geest, Hongye Fan, Hernán F. Peñaloza, William G. Bain, William G. Bain, Zeyu Xiong, Naina Kohli, Emily Larson, Mara L. G. Sullivan, Jonathan M. Franks, Donna B. Stolz, Ryota Ito, Kong Chen, Yohei Doi, Yohei Doi, Melanie J. Harriff, Melanie J. Harriff, Janet S. Lee, Janet S. Lee, Janet S. Lee   +19 more
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Complement-receptor-3 and scavenger-receptor-AI/II mediated myelin phagocytosis in microglia and macrophages

Neurobiology of Disease, 2003
Microglia and macrophages express the αM/β2 integrin complement-receptor-3 (CR3/MAC-1; CD11b/CD18) and scavenger-receptor-AI/II (SRAI/II). Both can mediate myelin phagocytosis.
Fanny Reichert, Shlomo Rotshenker
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Phagocytosis in Teleosts. Implications of the New Cells Involved

Biology, 2015
Phagocytosis is the process by which cells engulf some solid particles to form internal vesicles known as phagosomes. Phagocytosis is in fact a specific form of endocytosis involving the vesicular interiorization of particles. Phagocytosis is essentially
María Ángeles Esteban, Alberto Cuesta, Elena Chaves-Pozo, José Meseguer   +3 more
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Phagocytosis of microparticles increases responsiveness of macrophage-like cell lines U937 and THP-1 to bacterial lipopolysaccharide and lipopeptide

Scientific Reports, 2021
Following bacterial infection, macrophages produce pro-inflammatory cytokines in response to bacterial cell components, including lipopolysaccharide (LPS) and lipopeptide, and simultaneously phagocytize and digest the invading bacteria.
Takayuki Ueno, Yumi Yamamoto, Kiyoshi Kawasaki   +2 more
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Regulatory Role of Fc Receptor in mIgM+ B Lymphocyte Phagocytosis in Flounder (Paralichthys olivaceus)

Frontiers in Immunology, 2021
Fc receptor (FcR) is an important opsonin receptor on the surface of immune cells, playing an important role in antibody-dependent cell-mediated immunity.
Yanbo Hao, Xiaoqian Tang, Xiaoqian Tang, Jing Xing, Jing Xing, Xiuzhen Sheng, Heng Chi, Wenbin Zhan, Wenbin Zhan   +8 more
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Complement receptor-3 negatively regulates the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin

Journal of Neuroinflammation, 2012
Background Intact myelin, which normally surrounds axons, breaks down in Wallerian degeneration following axonal injury and during neurodegenerative diseases such as multiple sclerosis.
Hadas Smadar, Spira Maya, Hanisch Uwe-Karsten, Reichert Fanny, Rotshenker Shlomo   +4 more
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Phagocytic receptors activate and immune inhibitory receptor SIRPalpha inhibits phagocytosis through paxillin and cofilin

Frontiers in Cellular Neuroscience, 2014
The innate-immune function of phagocytosis of apoptotic cells, tissue-debris, pathogens and cancer cells is essential for homeostasis, tissue repair, fighting infection and combating malignancy.
Miri eGitik, Rachel eKleinhaus, Smadar eHadas, Fanny eReichert, Shlomo eRotshenker, Shlomo eRotshenker   +5 more
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SIRT1-induced deacetylation of Akt expedites platelet phagocytosis and delays HEMEC aging

Molecular Therapy: Nucleic Acids, 2021
Maintaining the health of the endothelium is of critical importance to prevention against cell aging. The current study was performed to clarify the role of sirtuin1 (SIRT1) in platelet phagocytosis in cell aging and identified its downstream molecular ...
Yong Lan, Min Dong, Yongjun Li, Yongpeng Diao, Zuoguang Chen, Yangfang Li   +5 more
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Phosphoinositides and phagocytosis [PDF]

The Journal of Cell Biology, 2001
Phosphoinositide 3 kinases (PI3Ks)**Abbreviation used in this paper: PI3K, phosphoinositide 3 kinase. are known as regulators of phagocytosis. Recent results demonstrate that class I and III PI3Ks act consecutively in phagosome formation and maturation, and that their respective products, phosphatidylinositol 3,4,5-trisphosphate (PI[3,4,5]P3) and ...
Gillooly, David J., Simonsen, Anne, Stenmark, Harald   +2 more
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