Results 41 to 50 of about 420,323 (395)

PhagoStat a scalable and interpretable end to end framework for efficient quantification of cell phagocytosis in neurodegenerative disease studies [PDF]

, 2023
Quantifying the phagocytosis of dynamic, unstained cells is essential for evaluating neurodegenerative diseases. However, measuring rapid cell interactions and distinguishing cells from background make this task very challenging when processing time-lapse phase-contrast video microscopy.
arxiv   +1 more source

Phagocytosis [PDF]

Immunity, 2005
Phagocytosis requires receptor-mediated recognition of particles, usually in the guise of infectious agents and apoptotic cells. Phagosomes fuse with lysosomes to generate phagolysosomes, which play a key role in enzymatic digestion of the internalized contents into component parts.
Lynda M. Stuart, Lynda M. Stuart, R. Alan B. Ezekowitz   +2 more
openaire   +3 more sources

PD-1 expression by tumor-associated macrophages inhibits phagocytosis and tumor immunity

Nature, 2017
Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor that is upregulated on activated T cells for the induction of immune tolerance.
S. Gordon, R. Maute, Ben W. Dulken, G. Hutter, B. George, Melissa N. Mccracken, Rohit Gupta, Jonathan M. Tsai, Rahul Sinha, Daniel M. Corey, A. Ring, A. Connolly, I. Weissman   +12 more
semanticscholar   +1 more source

Phagocytosis of Apoptotic Cells in Resolution of Inflammation

Frontiers in Immunology, 2020
Efficient inflammation resolution is important not only for the termination of the inflammatory response but also for the restoration of tissue integrity. An integral process to resolution of inflammation is the phagocytosis of dying cells by macrophages,
I. Kourtzelis, G. Hajishengallis, T. Chavakis   +2 more
semanticscholar   +1 more source

Complement receptor-3 negatively regulates the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin

Journal of Neuroinflammation, 2012
Background Intact myelin, which normally surrounds axons, breaks down in Wallerian degeneration following axonal injury and during neurodegenerative diseases such as multiple sclerosis.
Hadas Smadar, Spira Maya, Hanisch Uwe-Karsten, Reichert Fanny, Rotshenker Shlomo   +4 more
doaj   +1 more source

Phagocytic receptors activate and immune inhibitory receptor SIRPalpha inhibits phagocytosis through paxillin and cofilin

Frontiers in Cellular Neuroscience, 2014
The innate-immune function of phagocytosis of apoptotic cells, tissue-debris, pathogens and cancer cells is essential for homeostasis, tissue repair, fighting infection and combating malignancy.
Miri eGitik, Rachel eKleinhaus, Smadar eHadas, Fanny eReichert, Shlomo eRotshenker, Shlomo eRotshenker   +5 more
doaj   +1 more source

Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity

Nature Communications, 2020
Tumour cell phagocytosis by antigen presenting cells (APCs) is critical to the generation of antitumour immunity. However, cancer cells can evade phagocytosis by upregulating anti-phagocytosis molecule CD47.
Christina A. von Roemeling, Yifan Wang, Yaqing Qie, Hengfeng Yuan, Hai Zhao, Xiujie Liu, Zhaogang Yang, Mingming Yang, W. Deng, K. A. Bruno, Charles K. F. Chan, Andrew S. Lee, S. Rosenfeld, Kyuson Yun, Aaron J. Johnson, D. Mitchell, Wen Jiang, Betty Y. S. Kim   +17 more
semanticscholar   +1 more source

Interplay between FGFR2b-induced autophagy and phagocytosis: role of PLCγ-mediated signalling [PDF]

, 2017
Signalling of the epithelial splicing variant of the fibroblast growth factor receptor 2 (FGFR2b) induces both autophagy and phagocytosis in human keratinocytes.
Belleudi, Francesca, Nanni, Monica, Raffa, Salvatore, Ranieri, Danilo, Torrisi, Maria Rosaria   +4 more
core   +1 more source

Regulatory Role of Fc Receptor in mIgM+ B Lymphocyte Phagocytosis in Flounder (Paralichthys olivaceus)

Frontiers in Immunology, 2021
Fc receptor (FcR) is an important opsonin receptor on the surface of immune cells, playing an important role in antibody-dependent cell-mediated immunity.
Yanbo Hao, Xiaoqian Tang, Xiaoqian Tang, Jing Xing, Jing Xing, Xiuzhen Sheng, Heng Chi, Wenbin Zhan, Wenbin Zhan   +8 more
doaj   +1 more source

The mechanism of phagocytosis: two stages of engulfment [PDF]

Biophysical Journal 107:1542-1553 (2014), 2014
Despite being of vital importance to the immune system, the mechanism by which cells engulf relatively large solid particles during phagocytosis is still poorly understood. From movies of neutrophil phagocytosis of polystyrene beads, we measure the fractional engulfment as a function of time and demonstrate that phagocytosis occurs in two distinct ...
arxiv   +1 more source