Results 131 to 140 of about 22,892 (257)

The Paediatric BCG Vaccine Century: From Historical Success to Future Innovations

Acta Paediatrica, EarlyView.
ABSTRACT Aim The tuberculosis (TB) vaccine, Bacille‐Calmette‐Guérin (BCG), protects infants against severe forms of primary TB. Yet, it does not protect against pulmonary reactivation TB in adults. Methods A literature review was conducted between 1st January and 28th February 2025 using PubMed, Google Scholar and reports of the World Health ...
Stefan H. E. Kaufmann
wiley   +1 more source

Shaping cups into phagosomes and macropinosomes [PDF]

Nature Reviews Molecular Cell Biology, 2008
The ingestion of particles or cells by phagocytosis and of fluids by macropinocytosis requires the formation of large endocytic vacuolar compartments inside cells by the organized movements of membranes and the actin cytoskeleton. Fc-receptor-mediated phagocytosis is guided by the zipper-like progression of local, receptor-initiated responses that ...
openaire   +2 more sources

Rab10 regulates phagosome maturation and its overexpression rescues Mycobacterium-containing phagosomes maturation [PDF]

, 2010
Phagosome maturation follows a defined biochemical program and, in the vast majority of cases, the microbe inside the phagosome is killed and digested. Although, an important number of pathogens, including Mycobacterium tuberculosis, which kills around ...
Cardoso, Carla M. P., Vieira, Otilia V., Jordão, Luísa   +2 more
core   +1 more source

Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola

Insect Molecular Biology, EarlyView.
Malaria mosquito antimicrobial defence requires upregulation of lola. Attenuation of lola in the midgut of Anopheles albimanus mosquitoes inhibits the upregulation of immunity genes induced by challenge. Putative target genes of the Lola transcription factor were revealed by lola attenuation, including Cecropin‐C, Draper, PPAF2, Clip‐domain serine ...
Heidi Espadas‐Álvarez, Verónica Valverde‐Garduño   +1 more
wiley   +1 more source

Rapid phagosome isolation enables unbiased multiomic analysis of human microglial phagosomes [PDF]

Microglia are the resident macrophages of the central nervous system (CNS). Their phagocytic activity is central during brain development and homeostasis-and in a plethora of brain pathologies.
Schnell, Oliver, Abu-Reh, M., Rawat, Eshaan, Braswell, Brandyn, Prinz, Marco, Tholen, Stefan, Bell, George W., Beck, Jürgen, Buescher, J., Mittler, G., Rambold, Angelika S., Borner, G., Wogram, E., Dong, W., Braswell, B., Jaenisch, Rudolf, Abu-Remaileh, Monther, Dong, Wentao, Abu-Remaileh, M., Mittler, Gerhard, Prinz, M., Schnell, O., Sümpelmann, F., Buescher, Joerg M., Rambold, A., Akhtar, A., Akhtar, Asifa, Beck, J., Bell, G., Tholen, S., Khalil, Andrew, Fu, Dongdong, Schilling, O., Büscher, J., Sümpelmann, Felix, Fu, D., Wogram, Emile, Borner, Georg H.H., Vlachos, Andreas, Jaenisch, R., Rawat, E., Vlachos, A., Fernández Maestre, Inés, Fernández Maestre, I., Khalil, A., Schilling, Oliver, Maestre, I.   +46 more
core   +1 more source

Neutrophil Secretory Proteins Inhibit Calcium Oxalate Crystallisation and Crystal Growth, but Promote Crystal Aggregation

Immunology, EarlyView.
Calcium oxalate monohydrate (COM) crystals cause changes in the secretion of 29 proteins from neutrophil‐like cells, including those involved in neutrophil immune activation and intracellular metabolic adaptation. The neutrophil secreted proteins (secretome) also inhibit calcium oxalate crystallisation and crystal growth, but promote crystal ...
Chanettee Lertprapai, Paleerath Peerapen, Visith Thongboonkerd   +2 more
wiley   +1 more source

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

phagosome

Citation: 'phagosome' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13564 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Integrative methylation and miRNA dysregulation in dlPFC reveal distinct molecular signatures of suicide and non‐suicide subtypes in major depressive disorder

Psychiatry and Clinical Neurosciences, EarlyView.
Aim Major depressive disorder (MDD) is a leading cause of disability and carries a high risk of suicide. MicroRNAs (miRNAs) are epigenetic regulators implicated in MDD and can be regulated by DNA methylation, potentially reshaping downstream gene networks.
Aleena Francis, Yogesh Dwivedi
wiley   +1 more source

Understanding extracellular vesicle biology, isolation, and characterization: The theory of EV‐erything

Periodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad, Nima Farshidfar, Nathan E. Estrin, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +6 more
wiley   +1 more source