Results 1 to 10 of about 33,269 (261)
Better Together: Current Insights Into Phagosome-Lysosome Fusion
Frontiers in Immunology, 2021 Following phagocytosis, the nascent phagosome undergoes maturation to become a phagolysosome with an acidic, hydrolytic, and often oxidative lumen that can efficiently kill and digest engulfed microbes, cells, and debris.
Robin Yates, Yates Robin M
exaly +3 more sources
Francisella tularensisPhagosomal Escape Does Not Require Acidification of the Phagosome [PDF]
Infection and Immunity, 2009 ABSTRACTFollowing uptake,Francisella tularensisenters a phagosome that acquires limited amounts of lysosome-associated membrane glycoproteins and does not acquire cathepsin D or markers of secondary lysosomes. With additional time after uptake,F. tularensisdisrupts its phagosomal membrane and escapes into the cytoplasm.
Clemens, Daniel L +2 more
openaire +6 more sources
Biochemistry of the Phagosome: The Challenge to Study a Transient Organelle [PDF]
The Scientific World Journal, 2011 Phagocytes are specialized cells of the immune system, designed to engulf and destroy harmful microorganisms inside the newly formed phagosome. The latter is an intracellular organelle that is transformed into a toxic environment within minutes and ...
Oliver Nüsse
doaj +2 more sources
Isolation and Western Blotting of Latex-Bead Phagosomes to Track Phagosome Maturation [PDF]
, 2016 Phagocytosis plays an essential role in the immune system for the defense against invading microorganisms and the clearing of apoptotic cells. After internalization, the newly formed phagosome is constantly remodeled by fusion with early endosomes, late endosomes, and lysosomes.
Härtlova A +3 more
openaire +4 more sources
Phagosomal transport depends strongly on phagosome size [PDF]
Scientific Reports, 2017 AbstractMacrophages internalize pathogens for intracellular degradation. An important part of this process is the phagosomal transport from the cell periphery to the perinuclear region. Biochemical factors are known to influence the fate of phagosomes. Here, we show that the size of phagosomes also has a strong influence on their transport.
Keller, S., Berghoff, K., Kress, H.
openaire +4 more sources
Sec22b regulates phagosome maturation by promoting ORP8-mediated lipid exchange at endoplasmic reticulum-phagosome contact sites [PDF]
, 2023 Primary data linked to the publication "Sec22b regulates phagosome maturation by promoting ORP8-mediated lipid exchange at endoplasmic reticulum-phagosome contact sites" in Communications Biology Criado-Santos et al 2023. The dataset is subdivided into a
Nunes-Hasler, Paula
core +3 more sources
A Bumpy Ride of Mycobacterial Phagosome Maturation: Roleplay of Coronin1 Through Cofilin1 and cAMP
Frontiers in Immunology, 2021 Phagosome-lysosome fusion in innate immune cells like macrophages and neutrophils marshal an essential role in eliminating intracellular microorganisms.
Saradindu Saha +5 more
doaj +1 more source
Biology, 2021 Lyme disease is the most common vector-borne illness in North America and Europe. Its causative agents are spirochetes of the Borrelia burgdorferi sensu latu complex.
Philipp Woitzik, Stefan Linder
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2023 Tuberculosis (TB) is an infectious disease caused by the bacteria of the Mycobaterium tuberculosis (Mtb) complex. The modulation of the lipid metabolism has been implicated in the immune response regulation, including the formation of lipid droplets (LD ...
Patrícia Elaine de Almeida +5 more
doaj +1 more source
eLife, 2022 Autophagosomes are double-membrane intracellular vesicles that degrade protein aggregates, intracellular organelles, and other cellular components.
Omar Peña-Ramos +6 more
doaj +1 more source