Results 11 to 20 of about 32,198 (216)

Phagosomal Escape Does Not Require Acidification of the Phagosome [PDF]

Infection and Immunity, 2009
Following uptake, Francisella tularensis enters a phagosome that acquires limited amounts of lysosome-associated membrane glycoproteins and does not acquire cathepsin D or markers of secondary lysosomes. With additional time after uptake, F.
Marcus A. Horwitz, Daniel L. Clemens, Bai-Yu Lee, Clemens, Daniel L, Lee, Bai-Yu, Horwitz, Marcus A   +5 more
core   +5 more sources

Phagosomal transport depends strongly on phagosome size [PDF]

Scientific Reports, 2017
AbstractMacrophages internalize pathogens for intracellular degradation. An important part of this process is the phagosomal transport from the cell periphery to the perinuclear region. Biochemical factors are known to influence the fate of phagosomes. Here, we show that the size of phagosomes also has a strong influence on their transport.
Keller, S., Berghoff, K., Kress, H.
openaire   +4 more sources

Isolation and western blotting of latex-bead phagosomes to track phagosome maturation

, 2016
Phagocytosis plays an essential role in the immune system for the defense against invading microorganisms and the clearing of apoptotic cells. After internalization, the newly formed phagosome is constantly remodeled by fusion with early endosomes, late ...
Härtlova, Anetta, Peltier, Julien, Julien Peltier, Orsolya Bilkei-Gorzo, Anetta Härtlova, Trost, Matthias, Matthias Trost, Bilkei-Gorzo, Orsolya, Härtlova, Anetta,   +8 more
core   +4 more sources

Endosomal and Phagosomal SNAREs [PDF]

Physiological Reviews, 2018
The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein family is of vital importance for organelle communication. The complexing of cognate SNARE members present in both the donor and target organellar membranes drives the membrane fusion required for intracellular transport.
Ilse Dingjan, Peter T. A. Linders, Danielle R. J. Verboogen, Natalia H. Revelo, Martin ter Beest, Geert van den Bogaart   +5 more
openaire   +4 more sources

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

The Mycobacterium tuberculosis Phagosome [PDF]

, 2008
Tuberculosis is currently the most devastating human bacterial disease, causing millions of deaths annually and infecting an overwhelming percentage of the global population. Its success as a scourge lies in the ability of Mycobacterium tuberculosis to prevent normal phagolysosome biogenesis, essential to the destruction of invading microorganisms ...
Esteban A, Roberts, Vojo, Deretic
openaire   +2 more sources

TRPC6 channel translocation into phagosomal membrane augments phagosomal function [PDF]

Proceedings of the National Academy of Sciences, 2015
SignificanceHistorically, pulmonary infections treated with antibiotics killed bacteria while selecting for the unintended development of pathogenic resistance. One strategy to circumvent antibiotic resistance in pulmonary infection involves targeting the host phagosome and augmenting its function.
Riazanski, Vladimir, Gabdoulkhakova, Aida G., Boynton, Lin S., Eguchi, Raphael R., Deriy, Ludmila V., Hogarth, D. Kyle, Loaëc, Nadège, Oumata, Nassima, Galons, Hervé, Brown, Mary E., Shevchenko, Pavel, Gallan, Alexander J., Yoo, Sang Gune, Naren, Anjaparavanda P., Villereal, Mitchel L., Beacham, Daniel W., Bindokas, Vytautas P., Birnbaumer, Lutz, Meijer, Laurent, Nelson, Deborah J.   +19 more
openaire   +3 more sources

Analysis of phagosomal proteomes: From latex‐bead to bacterial phagosomes [PDF]

PROTEOMICS, 2010
Abstract Phagosomal proteome characterization has contributed significantly to the understanding of host–pathogen interaction and the mechanism of infectious diseases caused by intracellular bacteria. The latex bead‐containing phagosome has been widely used as a model system to study phagosomal proteomes at a global level. In contrast,
Qingbo, Li, Chinnaswamy, Jagannath, Prahlad K, Rao, Christopher R, Singh, Giovanni, Lostumbo   +4 more
openaire   +2 more sources

The macrophage marches on its phagosome: dynamic assays of phagosome function [PDF]

Nature Reviews Immunology, 2009
Professional phagocytes ingest particulate material to fulfil a diverse array of functions in a multicellular organism. The ancestral function of phagosomes is digestion; however, through evolution this degradative capacity has become pivotal to the adaptive immune response by processing antigens to be presented to lymphocytes.
Russell, David G, Vanderven, Brian C, Glennie, S, Mwandumba, Henry C, Heyderman, Robert   +4 more
openaire   +2 more sources

Phagosome proteomes open the way to a better understanding of phagosome function [PDF]

Genome Biology, 2007
Phagocytic cells take up microbes and other particles into membrane-bounded organelles called phagosomes. Studies on the protein and lipid composition of model phagosomes containing latex beads are the first step in a systems-biology approach to understanding how these organelles function.
Griffiths, Gareth, Mayorga, Luis
openaire   +2 more sources