Results 31 to 40 of about 33,269 (261)
Actin-based phagosome motility [PDF]
, 2002 Despite abundant evidence of actin's involvement at the particle internalization stage of phagocytosis, little is known about whether phagosomes undergo the same type of actin-based motility as observed with endocytic vesicles or such intracellular ...
Frederick S. Southwick +5 more
core +1 more source
Phagosome resolution regenerates lysosomes and maintains the degradative capacity in phagocytes [PDF]
, 2023 Phagocytes engulf unwanted particles into phagosomes that then fuse with lysosomes to degrade the enclosed particles. Ultimately, phagosomes must be recycled to help recover membrane resources that were consumed during phagocytosis and phagosome ...
Roberto Botelho (14518364) +8 more
core +1 more source
The Capsule of
mSphere, 2018 Phagosomal acidification is a critical cellular mechanism for the inhibition and killing of ingested microbes by phagocytic cells. The acidic environment activates microbicidal proteins and creates an unfavorable environment for the growth of many ...
Carlos M. De Leon-Rodriguez +4 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Understanding of how intracellular pathogens survive in their host cells is important to improve management of their diseases. This has been fruitful for intracellular bacteria, but it is an understudied area in fungal pathogens.
Emmanuel J. Santiago-Burgos +4 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2017 Phagocytosis, a critical early event in the microbicidal response of neutrophils, is now appreciated to serve multiple functions in a variety of cell types. Professional phagocytes play a central role in innate immunity by eliminating pathogenic bacteria,
Justin J. Lim +4 more
doaj +1 more source
Mechanism of Hip Arthropathy in Ankylosing Spondylitis: Abnormal Myeloperoxidase and Phagosome
Frontiers in Immunology, 2021 BackgroundThe pathogenesis of Ankylosing spondylitis (AS) has not been elucidated, especially involving hip joint disease. The purpose of this study was to analyze the proteome of diseased hip in AS and to identify key protein biomarkers.Material and ...
Chaojie Yu +8 more
doaj +1 more source
The Mycobacterium tuberculosis Phagosome [PDF]
, 2008 Tuberculosis is currently the most devastating human bacterial disease, causing millions of deaths annually and infecting an overwhelming percentage of the global population. Its success as a scourge lies in the ability of Mycobacterium tuberculosis to prevent normal phagolysosome biogenesis, essential to the destruction of invading microorganisms ...
Esteban A, Roberts, Vojo, Deretic
openaire +2 more sources
TRPC6 channel translocation into phagosomal membrane augments phagosomal function [PDF]
Proceedings of the National Academy of Sciences, 2015 SignificanceHistorically, pulmonary infections treated with antibiotics killed bacteria while selecting for the unintended development of pathogenic resistance. One strategy to circumvent antibiotic resistance in pulmonary infection involves targeting the host phagosome and augmenting its function.
Riazanski, Vladimir +19 more
openaire +3 more sources
Histoplasma Responses to Nutritional Immunity Imposed by Macrophage Activation
Journal of Fungi, 2019 The fungal pathogen Histoplasma capsulatum resides within the phagosome of host phagocytic cells. Within this intracellular compartment, Histoplasma yeast replication requires the acquisition of several essential nutrients, including metal ions.
Peter J. Brechting, Chad A. Rappleye
doaj +1 more source
Analysis of phagosomal proteomes: From latex‐bead to bacterial phagosomes [PDF]
PROTEOMICS, 2010 Abstract Phagosomal proteome characterization has contributed significantly to the understanding of host–pathogen interaction and the mechanism of infectious diseases caused by intracellular bacteria. The latex bead‐containing phagosome has been widely used as a model system to study phagosomal proteomes at a global level. In contrast,
Qingbo, Li +4 more
openaire +2 more sources