Results 41 to 50 of about 33,269 (261)
The macrophage marches on its phagosome: dynamic assays of phagosome function [PDF]
Nature Reviews Immunology, 2009 Professional phagocytes ingest particulate material to fulfil a diverse array of functions in a multicellular organism. The ancestral function of phagosomes is digestion; however, through evolution this degradative capacity has become pivotal to the adaptive immune response by processing antigens to be presented to lymphocytes.
Russell, David G +4 more
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trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans
eLife, 2022 The phagocytic receptor CED-1 mediates apoptotic cell recognition by phagocytic cells, enabling cell corpse clearance in Caenorhabditis elegans. Whether appropriate levels of CED-1 are maintained for executing the engulfment function remains unknown ...
Lei Yuan +4 more
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Phagosome proteomes open the way to a better understanding of phagosome function [PDF]
Genome Biology, 2007 Phagocytic cells take up microbes and other particles into membrane-bounded organelles called phagosomes. Studies on the protein and lipid composition of model phagosomes containing latex beads are the first step in a systems-biology approach to understanding how these organelles function.
Griffiths, Gareth, Mayorga, Luis
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Relationship between phagosome acidification, phagosome-lysosome fusion, and mechanism of particle ingestion [PDF]
, 1994 : The fate of pathogens ingested by macro-phages is dependent on phagosome acidification and fu-sion with different intracellular vesicles. Whereas the mode of particle recognition by the phagocyte seems the main determinant of phagosome-lysosome fusion,
Colette Foa +5 more
core +1 more source
Frontiers in Immunology, 2021 Phagocytosis is a receptor-mediated process used by cells to engulf a wide variety of particulates, including microorganisms and apoptotic cells. Many of the proteins involved in this highly orchestrated process are post-translationally modified with ...
Charneal L. Dixon +7 more
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Large-Scale Phagosome Preparation [PDF]
, 2009 Phagocytosis is the process by which cells engulf and destroy large particles such as pathogens or apoptotic cells. In this way, macrophages play a pivotal role in the resolution of microbial infections.
Adrien F. Vinet +4 more
core +1 more source
MicroRNAs as Regulators of Phagocytosis
Cells, 2022 MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression and thus act as important regulators of cellular phenotype and function. As their expression may be dysregulated in numerous diseases, they are of interest as biomarkers.
Wojciech Gierlikowski +1 more
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Protein phosphorylation during phagosome maturation [PDF]
, 1996 Phagolysosome biogenesis is driven by a series of interactions between phagosomes and organelles of the biosynthetic and endocytic pathways. The presence of endocytic markers on phagosomes suggests that phagosomes and endosomes share common structural ...
Desjardins, Michel +5 more
core +1 more source
Open Biology, 2021 The membranes of endosomes, phagosomes and macropinosomes can become damaged by the physical properties of internalized cargo, by active pathogenic invasion or by cellular processes, including endocytic maturation.
Eleanor Childs +3 more
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Isolation of bacteria-containing phagosomes by magnetic selection
BMC Cell Biology, 2008 Background There is a growing awareness of the importance of intracellular events in determining the outcome of infectious disease. To improve the understanding of such events, like phagosome maturation, we set out to develop a versatile technique for ...
Tapper Hans +2 more
doaj +1 more source