Results 61 to 70 of about 33,269 (261)
Deciphering the roles of phosphoinositide lipids in phagolysosome biogenesis
Communicative & Integrative Biology, 2016 Professional phagocytes engulf microbial invaders into plasma membrane-derived phagosomes. These mature into microbicidal phagolysosomes, leading to killing of the ingested microbe.
Andreas Jeschke, Albert Haas
doaj +1 more source
Leishmania promastigotes: building a safe niche within macrophages
Frontiers in Cellular and Infection Microbiology, 2012 Upon their internalization by macrophages, Leishmania promastigotes inhibit phagolysosome biogenesis. The main factor responsible for this inhibition is the promastigote surface glycolipid lipophosphoglycan (LPG).
Neda eMoradin, Albert eDescoteaux
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Biochemical Society Transactions, 1986 Phagosome-lysosome fusion plays an important role in the destruction of micro-organisms by phagocytic cells. Several approaches have been used to study the determinants of phagosome-lysosome fusion in mouse macrophages. Fusion can be assayed by electron microscopy using horseradish peroxidase or thorium dioxide as a marker for secondary lysosomes or by
Gabay, JE, Horwitz, MA, Cohn, ZA
openaire +4 more sources
The Mycobacterium bovis Bacille Calmette-Guérin Phagosome Proteome [PDF]
, 2010 Mycobacterium tuberculosis and Mycobacterium bovis bacille Calmette-Guérin (BCG) alter the maturation of their phagosomes and reside within a compartment that resists acidification and fusion with lysosomes.
Jethwaney, Deepa +11 more
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How phagocytic cells kill bacteria: Lessons from a professional killer
FEBS Open Bio, EarlyView.How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Proteomic analysis of the Mycobacterium avium-containing phagosome membrane [PDF]
, 2010 Includes abstract.Includes bibliographical references (leaves 139-158).Pathogenic mycobacteria, like [Mycobacterium tuberculosis] M.tb and Mycobacterium avium (M.av), reside intracellularly in phagosomes where they are able to survive, because they block
Pietersen, Ray-Dean Donovan
core
Image_5_A Bumpy Ride of Mycobacterial Phagosome Maturation: Roleplay of Coronin1 Through Cofilin1 and cAMP.tif [PDF]
, 2021 Phagosome-lysosome fusion in innate immune cells like macrophages and neutrophils marshal an essential role in eliminating intracellular microorganisms.
Ajay Vir Singh (11470543) +5 more
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Frontiers in Cellular and Infection Microbiology, 2010 The tularemia-causing bacterium Francisella tularensis is a facultative intracellular organism with a complex intracellular lifecycle that ensures its survival and proliferation in a variety of mammalian cell types, including professional phagocytes ...
Audrey eChong, Jean eCelli
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Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird +9 more
wiley +1 more source