Results 171 to 180 of about 20,078 (221)

mTORC1 inhibitors rapamycin and everolimus as host-directed therapy for tuberculosis. [PDF]

Infect Immun
van den Biggelaar RHGA, Ottenhoff THM.
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Adam9-deficient retinal pigment epithelium pseudopods maintain photoreceptor outer segment renewal despite subretinal space expansion. [PDF]

J Clin Invest
Lewis TR, Castillo CM, Phan S, Shores CR, Hayase KK, Kim KY, Ellisman MH, Alekseev O, Burns ME, Arshavsky VY.   +9 more
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Flow cytometry-based isolation of Salmonella -containing phagosomes combined with ultra-sensitive proteomics reveals novel insights into host-pathogen interactions

Chatterjee R, Marin Rubio JL, Cianfanelli FR, Frey A, Raymond BBA, Dannoura A, Valenzuela C, Meng M, Heunis T, Li M, Sidgwick F, Enninga J, Filby A, Trost M.   +13 more
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The resolution of phagosomes

Immunological Reviews, 2023
SummaryPhagocytosis is a fundamental immunobiological process responsible for the removal of harmful particulates. While the number of phagocytic events achieved by a single phagocyte can be remarkable, exceeding hundreds per day, the same phagocytic cells are relatively long‐lived.
Sivakami Mylvaganam, Spencer A. Freeman
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The NADPH Oxidase and the Phagosome

2020
The key purpose of phagocytosis is the destruction of pathogenic microorganisms. The phagocytes exert a wide array of killing mechanisms that allow mastering the vast majority of pathogens. One of these mechanisms consists in the production of reactive oxygen species inside the phagosome by a specific enzyme, the phagocyte NADPH oxidase. This enzyme is
Hana, Valenta, Marie, Erard, Sophie, Dupré-Crochet, Oliver, Nüβe   +3 more
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Measurement of phagosome-lysosome fusion and phagosomal pH

1994
Publisher Summary Phagosome–lysosome fusion has been assessed by several different methods. Most of these strategies involve either the identification of endogenous lysosomal markers in organelles containing ingested organisms or the colocalization of the phagocytosed organism with an exogenous marker endocytosed by the cell and sequestered within ...
T H, Steinberg, J A, Swanson
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Chloroquine and the fungal phagosome

Current Opinion in Microbiology, 2000
The antimalarial drug chloroquine accumulates inside the macrophage phagolysosome by ion trapping where it exerts potent antifungal activity against Histoplasma capsulatum and Cryptococcus neoformans by distinct mechanisms. Chloroquine inhibits growth of H. capsulatum by pH-dependent iron deprivation, whereas it is directly toxic to C.
S M, Weber, S M, Levitz, T S, Harrison
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Intracellular Transformation of Phagosomes

Biology Bulletin, 2004
The transformation of nascent phagosomes into forms capable of interacting with antimicrobial organelles of phagocytes, peroxisomes, depends on certain interactions between phagosomes and other vacuolar organelles. Phagosomes repeatedly interact with early and late endosomes through temporary contacts, which allows them to gain and lose complex sets of
P G, But, R A, Murav'ev, V A, Fomina, V V, Rogovin   +3 more
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