Results 211 to 220 of about 22,892 (257)

The resolution of phagosomes

Immunological Reviews, 2023
SummaryPhagocytosis is a fundamental immunobiological process responsible for the removal of harmful particulates. While the number of phagocytic events achieved by a single phagocyte can be remarkable, exceeding hundreds per day, the same phagocytic cells are relatively long‐lived.
Sivakami Mylvaganam, Spencer A. Freeman
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The NADPH Oxidase and the Phagosome

2020
The key purpose of phagocytosis is the destruction of pathogenic microorganisms. The phagocytes exert a wide array of killing mechanisms that allow mastering the vast majority of pathogens. One of these mechanisms consists in the production of reactive oxygen species inside the phagosome by a specific enzyme, the phagocyte NADPH oxidase. This enzyme is
Hana, Valenta, Marie, Erard, Sophie, Dupré-Crochet, Oliver, Nüβe   +3 more
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Measurement of phagosome-lysosome fusion and phagosomal pH

1994
Publisher Summary Phagosome–lysosome fusion has been assessed by several different methods. Most of these strategies involve either the identification of endogenous lysosomal markers in organelles containing ingested organisms or the colocalization of the phagocytosed organism with an exogenous marker endocytosed by the cell and sequestered within ...
T H, Steinberg, J A, Swanson
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Chloroquine and the fungal phagosome

Current Opinion in Microbiology, 2000
The antimalarial drug chloroquine accumulates inside the macrophage phagolysosome by ion trapping where it exerts potent antifungal activity against Histoplasma capsulatum and Cryptococcus neoformans by distinct mechanisms. Chloroquine inhibits growth of H. capsulatum by pH-dependent iron deprivation, whereas it is directly toxic to C.
S M, Weber, S M, Levitz, T S, Harrison
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NSF independent fusion of Salmonella‐containing late phagosomes with early endosomes [PDF]

FEBS Letters, 2010
Initial characterizations of live-Salmonella-containing early (LSEP) and late phagosomes (LSLP) in macrophages show that both phagosomes retain Rab5 and EEA1.
Seetharaman Parashuraman, Amitabha Mukhopadhyay   +1 more
exaly   +2 more sources

Intracellular Transformation of Phagosomes

Biology Bulletin, 2004
The transformation of nascent phagosomes into forms capable of interacting with antimicrobial organelles of phagocytes, peroxisomes, depends on certain interactions between phagosomes and other vacuolar organelles. Phagosomes repeatedly interact with early and late endosomes through temporary contacts, which allows them to gain and lose complex sets of
P G, But, R A, Murav'ev, V A, Fomina, V V, Rogovin   +3 more
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The Rab11a GTPase Controls Toll-like Receptor 4-Induced Activation of Interferon Regulatory Factor-3 on Phagosomes [PDF]

Immunity, 2010
SummaryToll-like receptor 4 (TLR4) is indispensable for recognition of Gram-negative bacteria. We described a trafficking pathway for TLR4 from the endocytic recycling compartment (ERC) to E. coli phagosomes.
Jørgen Stenvik, Harald Stenmark, Tom Mollnes   +2 more
exaly   +2 more sources

Phagosome dynamics and function

BioEssays, 2000
Phagocytosis of microorganisms and other particles is mediated most efficiently by receptors such as Fc-receptors (FcR) and complement-receptors (C3R). Interaction between these receptors and ligands on the particle results in signal transduction events that lead to actin polymerisation and phagosome formation. The phagosome then undergoes a maturation
T E, Tjelle, T, Lovdal, T, Berg
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Autophagosome and Phagosome

2008
Autophagy and phagocytosis are evolutionarily ancient processes functioning in capture and digestion of material found in the cellular interior and exterior, respectively. In their most primordial form, both processes are involved in cellular metabolism and feeding, supplying cells with externally obtained particulate nutrients or using portions of ...
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