Results 51 to 60 of about 666,519 (246)

A method for improving the properties of famotidine

Heliyon, 2023
According to crystal engineering, the pharmaceutical intermediate m-nitrobenzoic acid (MNBA), which contains a carboxylic acid group, was selected as a coformer (CCF) for drug cocrystallization with famotidine (FMT), and a new stable FMT salt cocrystal ...
Yongfeng Zhao, Ying Fan, Yan Zhang, Hong Xu, Min Li, Yunjie Zhu, Zhao Yang   +6 more
doaj   +1 more source

Novel Polymorphic Cocrystals of the Non-Steroidal Anti-Inflammatory Drug Niflumic Acid: Expanding the Pharmaceutical Landscape

Pharmaceutics, 2021
Any time the pharmaceutical industry develops a new drug, potential polymorphic events must be thoroughly described, because in a crystalline pharmaceutical solid, different arrangements of the same active pharmaceutical ingredient can yield to very ...
Francisco Javier Acebedo-Martínez, Carolina Alarcón-Payer, Antonio Frontera, Rafael Barbas, Rafel Prohens, Milena Di Crisci, Alicia Domínguez-Martín, Jaime Gómez-Morales, Duane Choquesillo-Lazarte   +8 more
doaj   +1 more source

Formation Thermodynamics of Carbamazepine with Benzamide, Para-Hydroxybenzamide and Isonicotinamide Cocrystals: Experimental and Theoretical Study

Pharmaceutics, 2022
Formation thermodynamic parameters for three cocrystals of carbamazepine (CBZ) with structurally related coformers (benzamide (BZA), para-hydroxybenzamide (4-OH-BZA) and isonicotinamide (INAM)) were determined by experimental (cocrystal solubility and ...
Alex N. Manin, Denis E. Boycov, Olga R. Simonova, Tatyana V. Volkova, Andrei V. Churakov, German L. Perlovich   +5 more
doaj   +1 more source

RS, S (+) - and R (−)-ibuprofen cocrystal polymorphs: Vibrational spectra, XRD measurement and DFT calculation studies

Heliyon
In this paper, cocrystal polymorphs of RS-ibuprofen (RS-IBU), S (+)-ibuprofen (S(+)-IBU), R (−)-ibuprofen (R(−)-IBU) with nicotinamide (NIC) were synthesized by different methods. RS-IBU is a chiral drug with only one chiral center in the molecule, which
Yaqi Jing, Qiuhui Zhao, Jiale Zhang, Jiadan Xue, Jianjun Liu, Jianyuan Qin, Zhi Hong, Yong Du   +7 more
doaj   +1 more source

Cocrystals of Praziquantel with Phenolic Acids: Discovery, Characterization, and Evaluation

Molecules, 2022
Solvent-assisted grinding (SAG) and solution slow evaporation (SSE) methods are generally used for the preparation of cocrystals. However, even by using the same solvent, active pharmaceutical ingredient (API), and cocrystal coformer (CCF), the ...
Shiying Yang, Qiwen Liu, Weiwen Ji, Qi An, Junke Song, Cheng Xing, Dezhi Yang, Li Zhang, Yang Lu, Guanhua Du   +9 more
doaj   +1 more source

Theophylline–gentisic acid (1/1)

Acta Crystallographica Section E, 2009
In the title 1:1 cocrystal, C7H8N4O2·C7H6O4, the anti-asthmatic drug theophylline (systematic name: 1,3-dimethyl-7H-purine-2,6-dione) and a non-steroidal anti-inflammatory drug, gentisic acid (systematic name: 2,5-dihydroxybenzoic acid ...
Srinivasulu Aitipamula, Pui Shan Chow, Reginald B. H. Tan   +2 more
doaj   +1 more source

COCRISTAIS: UMA ESTRATÉGIA PROMISSORA NA ÁREA FARMACÊUTICA

Química Nova
Pharmaceutical cocrystals have emerged as a useful strategy to improve the aqueous solubility of poorly water soluble drugs by aiming to enhance their oral absorption and bioavailability.
Alanny B. O. Rocha, Gislaine Kuminek, Tatiane C. Machado, Juliana Rosa, Gabriela S. Rauber, Paola A. A. Borba, Sana Siedler, Hellen K. Stulzer, Silvia Lucia Cuffini, Naír Rodríguez-Hornedo, Simone G. Cardoso   +10 more
doaj   +1 more source

Polymorphism basics and cocrystal technology.

Journal of Excipients and Food Chemicals, 2023
The adoption of cocrystals into oral pharmaceutical formulations is expected to propel this, as yet, moribund field into clinical and monetary prominence.
Shireesh P Apte, Mathew Cherian
doaj  

Synthesis of 1,2,3,4‐Tetrahydroisoquinoline‐3‐Carboxylic Acid‐Embedded Decapeptides: In Silico Studies and In Vitro Evaluation Against Breast Cancer

ChemistryOpen, EarlyView.
Synthesized decapeptides were designed and validated by in silico studies. They have significantly exhibited anticancer potential against breast cancer and MCF‐7 cell line. The above illustration specifies the synthetic pathway, biological screening, and the mode of action of the peptide in blocking the pathways responsible for the growth of cancer ...
Sunil Tivari, Naurin Lalani, Pritam Bagwe, Prashant Chandole, Ramesh Pawar, Enrique Delgado‐Alvarado, Abdallah Othman Ghnaim, Yashwantsinh Jadeja   +7 more
wiley   +1 more source

Semiconducting Quasi One‐Dimensional (PbBr2)[Pb2P14]2, a Lead Bromide Adduct and Violet Phosphorus Derivative

Zeitschrift für anorganische und allgemeine Chemie, EarlyView.
The quasi‐one‐dimensional semiconductor Pb5Br2P28 was examined in terms of its structural and electronic properties. Single‐crystal X‐ray diffraction (SC‐XRD) and Raman spectroscopy support its description as neutral [Pb2P14] and [PbBr2] units. Combined with its semiconducting properties and high flexibility, Pb5Br2P28 emerges as a promising candidate ...
Kathrin Vosseler, Felipe Jacques Lima Duarte, Tom Nilges   +2 more
wiley   +1 more source