Results 61 to 70 of about 1,115 (165)

Formation of Ciprofloxacin–Isonicotinic Acid Cocrystal Using Mechanochemical Synthesis Routes—An Investigation into Critical Process Parameters

Pharmaceutics, 2022
The mechanochemical synthesis of cocrystals has been introduced as a promising approach of formulating poorly water-soluble active pharmaceutical ingredients (APIs).
Maryam Karimi-Jafari, Ahmad Ziaee, Emmet O’Reilly, Denise Croker, Gavin Walker   +4 more
doaj   +1 more source

Intrinsically dominant conformational diversity in PDZ1 within the tandem PDZ1–PDZ2 of human syntenin‐1 underlied by crystal structures

Protein Science, Volume 35, Issue 6, June 2026.
Abstract The intrinsic dynamic asymmetry between homologous PDZ domains in multidomain scaffold proteins offers insight into how they achieve multivalent partner recognition. Through a systematic x‐ray crystallographic analysis of tandem PDZ1–PDZ2 domains in human syntenin‐1 (SDCBP/MDA‐9), we solved nine high‐resolution structures and uncovered ...
Natsuno Ando, Yuya Hanazono, Koya Sakuma, Nobutaka Numoto, Ryusei Hamajima, Takeshi Tenno, Atsunori Oshima, Nobutoshi Ito, Hidekazu Hiroaki   +8 more
wiley   +1 more source

Screening for Pharmaceutical Cocrystal Hydrates via Neat and Liquid-Assisted Grinding

, 2016
The formation of cocrystal hydrates represents a potential route to achieve molecular materials with improved properties, particularly stability under conditions of high relative humidity.
William Jones (1429504), Shyam Karki (2482303), Tomislav Friščić (2453254), W. D. Samuel Motherwell (2456020)   +3 more
core   +2 more sources

Understanding Water Activity in Deep Eutectic Solvents: Experimental Screening, Thermodynamic Modeling, and QSAR Predictions

ChemistrySelect, Volume 11, Issue 21, 4 June 2026.
Water activity (aw) was measured in eight DESs (10–90 wt% water). Strong DES–water interactions persist to ∼50 wt%, after which structure collapses toward aqueous‐like behavior. Redlich–Kister, Wilson, and COSMO‐RS models showed limited performance, whereas QSAR modeling using COSMOtherm‐derived σ‐profile descriptors significantly improved aw ...
Marko Rogošić, Matija Cepanec, Anja Damjanović, Marijan Logarušić, Ana Jurinjak Tušek, Ivana Varenina, Marina Cvjetko Bubalo   +6 more
wiley   +1 more source

A Review on Pharmaceutical Cocrystals

International Journal of Pharmaceutical Research and Applications
Pharmaceutical cocrystals are crystalline materials composed of two or more different molecules, at least one being an active pharmaceutical ingredient (API), in a fixed stoichiometric ratio, held together by non-covalent interactions.Cocrystal can be prepared by cocrystallization method.
Samina Sameer, Shinta Babu Shinta Babu, Aparna P Aparna P, Dr.Prasobh G R Dr.Prasobh G R   +3 more
openaire   +1 more source

Predicting the Solubility of Pharmaceutical Cocrystals in Solvent/Anti-Solvent Mixtures

Molecules, 2016
In this work, the solubilities of pharmaceutical cocrystals in solvent/anti-solvent systems were predicted using PC-SAFT in order to increase the efficiency of cocrystal formation processes.
Linda Lange, Stefan Heisel, Gabriele Sadowski   +2 more
doaj   +1 more source

2D Monte Carlo Simulation of Cocrystal Formation Using Patchy Particles

Crystals, 2022
Cocrystals of Active Pharmaceutical Ingredients (APIs) are an attractive therapeutic alternative to salt formations. However, due to the molecular scale processes involved, the earliest stages of cocrystal formation remain poorly understood.
Bogdan Ranguelov, Christo Nanev
doaj   +1 more source

Structure and intermolecular interactions of the rare amide–pyridine synthon: a cocrystal of nicotinamide and 2‐chloro‐3‐hydroxypyridine

Acta Crystallographica Section C, Volume 82, Issue 6, Page 267-276, June 2026.
Considering its low occurrence in the Cambridge Structural Database, is the amide–pyridyl synthon easy to form, and what structural factors affects its interaction energy and its subsequent formation?Nicotinamide (Nico) and derivatives of pyridine are important materials in both the pharmaceutical and agrochemical industries.
Oluwatoyin Akerele, Andreas Lemmerer
wiley   +1 more source

Enhancing the Solubility of Indomethacin: A Breakthrough with Cocrystal Formation

Pharmaceuticals
Background/objectives: Pharmaceutical cocrystals have emerged as a promising strategy to enhance the solubility and bioavailability of poorly water-soluble drugs.
Hugo Pardo, Víctor Guarnizo-Herrero, Borja Martínez-Alonso, Mª Ángeles Peña Fernández   +3 more
doaj   +1 more source

The evolving role of structural biology in pharma: integration of X‐ray crystallography, cryo‐electron microscopy and beyond

Acta Crystallographica Section D, Volume 82, Issue 6, Page 587-602, June 2026.
This review describes how an integrated structural biology platform at Merck Sharp & Dohme LLC, Rahway, New Jersey, USA, combining X‐ray crystallography, cryo‐EM, MicroED and cryo‐ET, enables seamless three‐dimensional insights from molecular to cellular length scales.
Jill E. Chrencik, Hua-Poo Su, Yacob Gomez Llorente, Rachel L. Palte, Daniel J. Klein, Robert P. Hayes, Sadie P. Antine, Guilermo A. Asmar-Rovira, Nicole Bertoletti, Noel J. Byrne, Brittany L. Carroll, Ciro D. Cordeiro, Kaylynn Curfman, James Dutko, Michael J. Eddins, Thierry Fischmann, Barani Govindarajan, Corey W. Hecksel, Thu Ho, Kaspar Hollenstein, Mee Ra Hong, Alan Hruza, Andrii Ishchenko, Maru Jaime-Garza, Matt J. Jaremko, Hayley L. Knox, James Kostas, Harini Krishnamurthy, Ioannis Manolaridis, Cameron L. Noland, Andrea T. Partridge, Sangita B. Patel, Paul Reichert, John C. Reid, Catarina Felisberto-Rodrigues, Chitra A. Shintre, Jennifer M. Shipman, Elakkiya Tamilselvan, Morgan E. Walker, Susanne N. Walker, Renjing Wang, Katharine M. Wright, Tien-Jui Yen, Byung-Kuk Yoo, Sandra B. Gabelli   +44 more
wiley   +1 more source