Recent advances in pharmaceutical cocrystals of theophylline [PDF]
Natural Products and BioprospectingCurrently, cocrystallization is a promising strategy for tailoring the physicochemical properties of active pharmaceutical ingredients. Theophylline, an alkaloid and the most primary metabolite of caffeine, is a readily available compound found in tea ...
Yanxiao Jia +7 more
doaj +4 more sources
Pharmaceutical cocrystal of antibiotic drugs: A comprehensive review
Heliyon, 2022 Pharmaceutical cocrystals, which contain at least one active pharmaceutical ingredient (API), are still an attention-grabbing field for researchers. Two or more discrete molecules unite together by non-covalent bonds, e.g., hydrogen, Van der Waals, and π⋯
Mais Bashimam, Hind El-Zein
doaj +3 more sources
Structural Characterization of Pharmaceutical Cocrystals with the Use of Laboratory X-ray Powder Diffraction Patterns [PDF]
Crystals, 2023 X-ray powder diffraction is a vital analytical tool that is used in pharmaceutical science. It is increasingly used to establish the crystal structure of a new pharmaceutical substance, in particular, cocrystal or its polymorphic forms.
Vladimir V. Chernyshev
doaj +2 more sources
Obtaining Cocrystals by Reaction Crystallization Method: Pharmaceutical Applications [PDF]
Pharmaceutics, 2021 Cocrystals have gained attention in the pharmaceutical industry due to their ability to improve solubility, stability, in vitro dissolution rate, and bioavailability of poorly soluble drugs. Conceptually, cocrystals are multicomponent solids that contain
Isabela Fanelli Barreto Biscaia +3 more
doaj +3 more sources
Flavonoid-Based Cocrystals: A Comprehensive Study on Their Synthesis, Characterization, Physicochemical Properties and Applications [PDF]
MoleculesFlavonoids are naturally occurring compounds with reported anticancer, antimicrobial, anti-inflammatory, cardio-protective and antioxidant effects. They are increasingly incorporated in functional foods designed to promote health, enhance well-being, and
Urszula Izabela Maciołek +4 more
doaj +2 more sources
Pharmaceutical Cocrystals of Ethenzamide: Molecular Structure Analysis Based on Vibrational Spectra and DFT Calculations. [PDF]
Int J Mol Sci, 2022 Wan M +7 more
europepmc +3 more sources
Enhancing the Solubility of Indomethacin: A Breakthrough with Cocrystal Formation [PDF]
PharmaceuticalsBackground/objectives: Pharmaceutical cocrystals have emerged as a promising strategy to enhance the solubility and bioavailability of poorly water-soluble drugs.
Hugo Pardo +3 more
doaj +2 more sources
Cocrystallization of Ezetimibe with Organic Acids: Stoichiometric Optimization for Improved Solubility and Bioavailability [PDF]
PharmaceuticsBackground/Objectives: Pharmaceutical cocrystallization offers a promising strategy to enhance drug properties while preserving molecular integrity.
Ravi Maharjan +7 more
doaj +2 more sources
Predicting the Solubility of Pharmaceutical Cocrystals in Solvent/Anti-Solvent Mixtures. [PDF]
Molecules, 2016 Lange L, Heisel S, Sadowski G.
europepmc +3 more sources
Urea as a Cocrystal Former-Study of 3 Urea Based Pharmaceutical Cocrystals. [PDF]
Pharmaceutics, 2021 Cocrystallization is commonly used for its ability to improve the physical properties of APIs, such as solubility, bioavailability, compressibility, etc. The pharmaceutical industry is particularly interested in those cocrystals comprising a GRAS former in connection with the target API.
Leng F, Robeyns K, Leyssens T.
europepmc +6 more sources