Results 21 to 30 of about 2,349 (173)
Superior Dissolution Behavior and Bioavailability of Pharmaceutical Cocrystals and Recent Regulatory Issues [PDF]
ACS Medicinal Chemistry Letters, 2022 Jian-Rong Wang, Xuefeng Mei
exaly +2 more sources
Cocrystallization of Ezetimibe with Organic Acids: Stoichiometric Optimization for Improved Solubility and Bioavailability [PDF]
PharmaceuticsBackground/Objectives: Pharmaceutical cocrystallization offers a promising strategy to enhance drug properties while preserving molecular integrity.
Ravi Maharjan +7 more
doaj +2 more sources
COCRISTAIS: UMA ESTRATÉGIA PROMISSORA NA ÁREA FARMACÊUTICA [PDF]
Química Nova, 2016 Pharmaceutical cocrystals have emerged as a useful strategy to improve the aqueous solubility of poorly water soluble drugs by aiming to enhance their oral absorption and bioavailability.
Alanny B. O. Rocha +10 more
doaj +2 more sources
Pharmaceutical cocrystals: from serendipity to design to application [PDF]
Drug Discovery Today, 2019 The field of pharmaceutical cocrystals has reached a tipping point, particularly because cocrystals can improve the physicochemical properties of drugs without compromising their therapeutic benefit. Accounts of cocrystal investigations in the literature started in earnest in 2003 and patent applications soon followed.
Oisin N. Kavanagh +3 more
openaire +4 more sources
Crystals, 2022 The most favored approach for drug administration is the oral route. Several anticancer drugs come under this category and mostly lack solubility and oral bioavailability, which are the most common causes of inadequate clinical efficiency. Enhancing oral
Divya Dhatri Kara, Mahalaxmi Rathnanand
doaj +1 more source
Enhanced Dissolution of Naproxen by Combining Cocrystallization and Eutectic Formation
Pharmaceutics, 2021 Improving dissolution properties of active pharmaceutical ingredients (APIs) is a critical step in drug development with the increasing occurrence of sparingly soluble APIs.
Hakyeong Kim, Soeun Jang, Il Won Kim
doaj +1 more source
Pharmaceutical Cocrystals and Their Physicochemical Properties [PDF]
Crystal Growth & Design, 2009 This review article will highlight and discuss the advances made over the last 10 years pertaining to physical and chemical property improvements through pharmaceutical cocrystals and, hopefully, draw closer the fields of crystal engineering and pharmaceutical sciences.
Schultheiss, Nate, Newman, Ann
openaire +2 more sources
Antibiotics, 2021 Cocrystallization is a promising approach to alter physicochemical properties of active pharmaceutical ingredients (hereafter abbreviated as APIs) bearing poor profile.
Noor Ul Islam +6 more
doaj +1 more source
Synthesis and Characterization of Nano-Sized 4-Aminosalicylic Acid–Sulfamethazine Cocrystals
Pharmaceutics, 2021 Drug–drug cocrystals are formulated to produce combined medication, not just to modulate active pharmaceutical ingredient (API) properties. Nano-crystals adjust the pharmacokinetic properties and enhance the dissolution of APIs.
Ala’ Salem +8 more
doaj +1 more source
Cocrystals of Praziquantel with Phenolic Acids: Discovery, Characterization, and Evaluation
Molecules, 2022 Solvent-assisted grinding (SAG) and solution slow evaporation (SSE) methods are generally used for the preparation of cocrystals. However, even by using the same solvent, active pharmaceutical ingredient (API), and cocrystal coformer (CCF), the ...
Shiying Yang +9 more
doaj +1 more source