Results 31 to 40 of about 2,349 (173)

Matrix Assisted Cocrystallization as an example of continuous and scalable method of obtaining pharmaceutical cocrystals on an industrial scale [PDF]

Farmacja Polska, 2021
Cocrystals can be defined as crystalline solids composed of at least two compounds in a stoichiometric ratio which interact nonionically. While one of the components is an active pharmaceutical ingredient (API) the term ‘pharmaceutical cocrystal’ could ...
Anna Magdalena Gołkowska, Aleksandra Jowita Dyba, Marta Maria Kozakiewicz, Karol Przemysław Nartowski   +3 more
doaj   +1 more source

SpeedMixing: Rapid Synthesis and Discovery of Model Pharmaceutical Cocrystals without Milling or Grinding Media

, 2022
We present SpeedMixing, a rapid blending technology, as an approach for the mechanochemical discovery and synthesis of model pharmaceutical cocrystals without the need for bulk solvents and milling/grinding media.
Hatem, Titi, Igor, Huskic, Yong, Teoh, Ghada, Ayoub, Tomislav, Friscic, Brad, Herrmann, Christopher, Nickels   +6 more
core   +1 more source

Pharmaceutical Cocrystals: An Overview [PDF]

Indian Journal of Pharmaceutical Sciences, 2017
Poor aqueous solubility and low oral bioavailability of an active pharmaceutical ingredient are the major constraints during the development of new product. Various approaches have been used for enhancement of solubility of poorly aqueous soluble drugs, but success of these approaches depends on physical and chemical nature of molecules being developed.
S Kumar, A Nanda
openaire   +1 more source

Creating Cocrystals: A Review of Pharmaceutical Cocrystal Preparation Routes and Applications [PDF]

Crystal Growth & Design, 2018
peer ...
Maryam Karimi-Jafari, Luis Padrela, Gavin M. Walker, Denise M. Croker   +3 more
openaire   +1 more source

Pharmaceutical Cocrystals: An Emerging Approach to Modulate Physicochemical Properties of Active Pharmaceutical Ingredients

, 2023
Most of the Active Pharmaceutical Ingredients (APIs) are typically formulated and administered to patients in oral solid dosage forms due to ease of administration, patient compliance and cost effectiveness.
Jadhav, Amrapali B., Amrapali B. Jadhav, Suraj Ankush Tupe, Shital Prabhakar Khandagale, Khandagale, Shital Prabhakar, Tupe, Suraj Ankush   +5 more
core   +1 more source

Drug‑Drug and Drug‑Nutraceutical Cocrystal/Salt as Alternative Medicine for Combination Therapy: A Crystal Engineering Approach

Crystals, 2018
The pre-formulation of pharmaceutical cocrystals and salts is a concept of crystal engineering that has emerged as a promising technique for drug development in pharmaceutical industry.
Ranjit Thakuria, Bipul Sarma
doaj   +1 more source

Effect of Surfactants and Polymers on the Dissolution Behavior of Supersaturable Tecovirimat-4-Hydroxybenzoic Acid Cocrystals

Pharmaceutics, 2021
(1) Background: Pharmaceutical cocrystals have attracted remarkable interest and have been successfully used to enhance the absorption of poorly water-soluble drugs.
Yumiao Feng, Yuanyuan Meng, Fangyun Tan, Lin Lv, Zhiping Li, Yuli Wang, Yang Yang, Wei Gong, Meiyan Yang   +8 more
doaj   +1 more source

Novel Cocrystals of Vonoprazan: Machine Learning-Assisted Discovery

Pharmaceutics, 2022
Vonoprazan (VPZ) is the first-in-class potassium-competitive acid blocker (P-CAB), and has many advantages over proton pump inhibitors (PPIs). It is administered as a fumarate salt for the treatment of acid-related diseases, including reflux esophagitis,
Min-Jeong Lee, Ji-Yoon Kim, Paul Kim, In-Seo Lee, Medard E. Mswahili, Young-Seob Jeong, Guang J. Choi   +6 more
doaj   +1 more source

The effects of pH, surfactant, ion concentration, coformer, and molecular arrangement on the solubility behavior of myricetin cocrystals

Acta Pharmaceutica Sinica B, 2019
Pharmaceutical cocrystals are a promising technology that can be used to improve the solubility of poor aqueous compounds. The objective of this study was to systematically investigate the solubility of myricetin (MYR) cocrystals, including their kinetic
Shuzhen Ren, Mingyu Liu, Chao Hong, Guowen Li, Jiabin Sun, Jianying Wang, Lei Zhang, Yan Xie   +7 more
doaj   +1 more source

Preparation, characterization and evaluation of fenofibrate: benzoic acid cocrystals with enhanced pharmaceutical properties

Future Journal of Pharmaceutical Sciences, 2021
Background Cocrystallization process involved the understanding of interaction at molecular level between two molecules in context to their crystal packing and designing of new solids having improved physicochemical as well as pharmaceutical properties ...
Braham Dutt, Manjusha Choudhary, Vikas Budhwar   +2 more
doaj   +1 more source