Results 51 to 60 of about 1,303 (119)

Cocrystallization and Micronization as Strategies to Optimize the Bioavailability of Naringin and Naringenin Molecules: A Comprehensive Review of In Vivo and In Vitro Pharmaceutical Applications

Crystal Research and Technology, Volume 61, Issue 7, July 2026.
Naringin and naringenin exhibit well‐recognized therapeutic potential; however, they face limitations related to solubility and bioavailability. Micronization increases surface area and enhances absorption. Notably, cocrystallization stands out as a primary strategy for particle optimization, as it refines physicochemical properties, improves ...
Emilia Rodrigues Almeida, Kanandra Taisa Bertoncello, Ketelin Zamin Kuhn, Liz Girardi Müller, J. Vladimir Oliveira   +4 more
wiley   +1 more source

Exploring Antimicrobial Activities of Fixed Oil From Sanguisorba minor Seeds by In Vitro and In Silico Analysis

ChemistryOpen, Volume 15, Issue 7, July 2026.
The fixed oil from Sanguisorba minor Scop. seeds exhibits low antioxidant activity in DPPH• and ABTS+ assays, while it demonstrates high antimicrobial activity, with MBC (22.5 ‐ 45 μL/mL) and MFC (5.625 ‐ 11.25 μL/mL) values. Linoleic acid (43.26%), α‐linolenic acid (25.31%), and oleic acid (20.73%), identified by GC‐MS as the main fatty acids, are ...
Zehra Torun, Tuba Unver, Harun Uslu, Bunyamin Goktas   +3 more
wiley   +1 more source

Dissolution Advantage of Nitazoxanide Cocrystals in the Presence of Cellulosic Polymers

Pharmaceutics, 2019
The effect of hydroxypropyl methylcellulose (HPMC) and methylcellulose (Methocel® 60 HG) on the dissolution behavior of two cocrystals derived from nitazoxanide (NTZ), viz., nitazoxanide-glutaric acid (NTZ-GLU, 1:1) and nitazoxanide-succinic acid ...
Reynaldo Salas-Zúñiga, Christian Rodríguez-Ruiz, Herbert Höpfl, Hugo Morales-Rojas, Obdulia Sánchez-Guadarrama, Patricia Rodríguez-Cuamatzi, Dea Herrera-Ruiz   +6 more
doaj   +1 more source

Advancing Antiviral Design: Integrating Natural Products, Computation and Targeted Delivery

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
A stepwise translational framework linking natural‐product discovery, computational prioritisation, experimental validation, lead optimisation and targeted delivery is proposed to advance antiviral design. ABSTRACT The COVID‐19 pandemic highlighted the role of rapid viral mutation and global connectivity in accelerating viral emergence and spread ...
Adedayo Ayodeji Lanrewaju, Abimbola Motunrayo Folami, Saheed Sabiu, Feroz Mahomed Swalaha   +3 more
wiley   +1 more source

COCRISTAIS: UMA ESTRATÉGIA PROMISSORA NA ÁREA FARMACÊUTICA

Química Nova
Pharmaceutical cocrystals have emerged as a useful strategy to improve the aqueous solubility of poorly water soluble drugs by aiming to enhance their oral absorption and bioavailability.
Alanny B. O. Rocha, Gislaine Kuminek, Tatiane C. Machado, Juliana Rosa, Gabriela S. Rauber, Paola A. A. Borba, Sana Siedler, Hellen K. Stulzer, Silvia Lucia Cuffini, Naír Rodríguez-Hornedo, Simone G. Cardoso   +10 more
doaj   +1 more source

Supramolecular synthon hierarchy in sulfonamide cocrystals with syn-amides and N-oxides

IUCrJ, 2019
Sulfonamide drugs are well known antibacterial and antimicrobial molecules for pharmaceutical development. Building a library of suitable supramolecular synthons for the sulfonamide functional group and understanding their crystal structures with partner
Geetha Bolla, Ashwini Nangia
doaj   +1 more source

Structure‐Based Design, Synthesis, and Evaluation of Novel Ponatinib Derivatives With a Significantly Altered Selectivity Profile

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
We developed new derivatives of the cancer drug ponatinib, significantly reducing and altering its spectrum of target kinases. Compound 5 retained the efficacy in inhibiting the colony formation of MDA‐MB‐231 cells and acted primarily on B‐Raf and Flt‐1 as its main targets in a kinase panel.
Tobias Betzholz, Ting Liu, Andreas Krämer, Verena Dederer, Stefan Knapp, Sebastian Mathea, Christian Ducho, Matthias Engel   +7 more
wiley   +1 more source

Intrinsically dominant conformational diversity in PDZ1 within the tandem PDZ1–PDZ2 of human syntenin‐1 underlied by crystal structures

Protein Science, Volume 35, Issue 6, June 2026.
Abstract The intrinsic dynamic asymmetry between homologous PDZ domains in multidomain scaffold proteins offers insight into how they achieve multivalent partner recognition. Through a systematic x‐ray crystallographic analysis of tandem PDZ1–PDZ2 domains in human syntenin‐1 (SDCBP/MDA‐9), we solved nine high‐resolution structures and uncovered ...
Natsuno Ando, Yuya Hanazono, Koya Sakuma, Nobutaka Numoto, Ryusei Hamajima, Takeshi Tenno, Atsunori Oshima, Nobutoshi Ito, Hidekazu Hiroaki   +8 more
wiley   +1 more source

Characterizations and Assays of α-Glucosidase Inhibition Activity on Gallic Acid Cocrystals: Can the Cocrystals be Defined as a New Chemical Entity During Binding with the α-Glucosidase?

Molecules, 2020
Cocrystallization with co-former (CCF) has proved to be a powerful approach to improve the solubility and even bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs).
Na Xue, Yutao Jia, Congwei Li, Binnan He, Caiqin Yang, Jing Wang   +5 more
doaj   +1 more source

Boron‐10 carriers and their applications in boron neutron capture therapy

Precision Radiation Oncology, Volume 10, Issue 2, Page 205-241, June 2026.
Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Dachao Tang, Mengqi Shi, Zhichen Mao, Weiya Chen, Xiaoling Li, Xiao Yan Zhao, Zhigang Liu, Xiao Xu   +7 more
wiley   +1 more source