Results 61 to 70 of about 1,303 (119)
ChemistrySelect, Volume 11, Issue 21, 4 June 2026.Water activity (aw) was measured in eight DESs (10–90 wt% water). Strong DES–water interactions persist to ∼50 wt%, after which structure collapses toward aqueous‐like behavior. Redlich–Kister, Wilson, and COSMO‐RS models showed limited performance, whereas QSAR modeling using COSMOtherm‐derived σ‐profile descriptors significantly improved aw ...
Marko Rogošić +6 more
wiley +1 more source
The Stoichiometry of TCNQ-Based Organic Charge-Transfer Cocrystals
Crystals, 2020 Organic charge-transfer cocrystals (CTCs) have attracted significant research attention due to their wide range of potential applications in organic optoelectronic devices, organic magnetic devices, organic energy devices, pharmaceutical industry, etc ...
Jiaoyang Gao +3 more
doaj +1 more source
Acta Crystallographica Section C, Volume 82, Issue 6, Page 267-276, June 2026.Considering its low occurrence in the Cambridge Structural Database, is the amide–pyridyl synthon easy to form, and what structural factors affects its interaction energy and its subsequent formation?Nicotinamide (Nico) and derivatives of pyridine are important materials in both the pharmaceutical and agrochemical industries.
Oluwatoyin Akerele, Andreas Lemmerer
wiley +1 more source
Acta Crystallographica Section D, Volume 82, Issue 6, Page 587-602, June 2026.This review describes how an integrated structural biology platform at Merck Sharp & Dohme LLC, Rahway, New Jersey, USA, combining X‐ray crystallography, cryo‐EM, MicroED and cryo‐ET, enables seamless three‐dimensional insights from molecular to cellular length scales.
Jill E. Chrencik +44 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 10, 27 May 2026.We developed a targeted covalent inhibitor for the p300/CBP‐associated factor (PCAF) bromodomain. Our lead molecule, 10, labeled a unique lysine residue in the PCAF bromodomain, demonstrated potent inhibition in biophysical/biochemical assays, and engaged the PCAF bromodomain in cells.
Richard R. Ede +9 more
wiley +1 more source
Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach
Pharmaceutics, 2020 In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter
Xavier Buol +6 more
doaj +1 more source
Acemetacin cocrystal structures by powder X-ray diffraction
IUCrJ, 2017 Cocrystals of acemetacin drug (ACM) with nicotinamide (NAM), p-aminobenzoic acid (PABA), valerolactam (VLM) and 2-pyridone (2HP) were prepared by melt crystallization and their X-ray crystal structures determined by high-resolution powder X-ray ...
Geetha Bolla +2 more
doaj +1 more source
Recent Advances in Pharmaceutical Cocrystals: From Bench to Market. [PDF]
Front Pharmacol, 2021 Kumar Bandaru R +6 more
europepmc +1 more source
Pharmaceutical Cocrystals of Ethenzamide: Molecular Structure Analysis Based on Vibrational Spectra and DFT Calculations. [PDF]
Int J Mol Sci, 2022 Wan M +7 more
europepmc +1 more source
Vibrational Spectroscopy for Cocrystals Screening. A Comparative Study
Molecules, 2018 A recurrent problem faced by the pharmaceutical industry when formulating drug products concerns poorly soluble drugs, which, despite having desirable pharmacological activity, present limited bioavailability.
Marisa Rodrigues +2 more
doaj +1 more source