Results 51 to 60 of about 1,824 (206)

Semiconducting Quasi One‐Dimensional (PbBr2)[Pb2P14]2, a Lead Bromide Adduct and Violet Phosphorus Derivative

Zeitschrift für anorganische und allgemeine Chemie, EarlyView.
The quasi‐one‐dimensional semiconductor Pb5Br2P28 was examined in terms of its structural and electronic properties. Single‐crystal X‐ray diffraction (SC‐XRD) and Raman spectroscopy support its description as neutral [Pb2P14] and [PbBr2] units. Combined with its semiconducting properties and high flexibility, Pb5Br2P28 emerges as a promising candidate ...
Kathrin Vosseler, Felipe Jacques Lima Duarte, Tom Nilges   +2 more
wiley   +1 more source

Characterization and Quality Control of Pharmaceutical Cocrystals

CHEMICAL & PHARMACEUTICAL BULLETIN, 2016
Recent active research and new regulatory guidance on pharmaceutical cocrystals have increased the rate of their development as promising approaches to improve handling, storage stability, and bioavailability of poorly soluble active pharmaceutical ingredients (APIs).
Ken‐ichi Izutsu, Tatsuo Koide, Noriyuki Takata, Yukihiro Ikeda, Makoto Ono, Motoki Inoue, Toshiro Fukami, Etsuo Yonemochi   +7 more
openalex   +4 more sources

A Hanks‐type bacterial kinase, PknS, directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation

The FEBS Journal, EarlyView.
The Xanthomonas citri Hanks‐type kinase PknS autophosphorylates and directly phosphorylates the alternative sigma factor EcfK at five residues. Besides the conserved residue T51 in the σ2 domain, phosphorylation of a residue in the linker between σ2 and σ4 is critical for EcfK activation by promoting its interaction with a positively charged pocket in ...
Lídia dos Passos Lima, Dev Sriranganadane, Daiane Laise da Silva, Natália C. Drebes Dörr, Enzo Breviglieri Sichi Mello, Caio Vinicius dos Reis, Rogério Ferreira Lourenço, José Felipe Teixeira da Silva Santos, Anita Salmazo, Brenno Wendler Miranda, Katlin B. Massirer, Rafael M. Couñago, Cristina E. Alvarez‐Martinez   +12 more
wiley   +1 more source

Modularity and three-dimensional isostructurality of novel synthons in sulfonamide–lactam cocrystals

IUCrJ, 2015
The design of novel supramolecular synthons for functional groups relevant to drugs is an essential prerequisite for applying crystal engineering in the development of novel pharmaceutical cocrystals.
Geetha Bolla, Sudhir Mittapalli, Ashwini Nangia   +2 more
doaj   +1 more source

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source

Repurposing of Inhibitors of Plasmodial Aspartate Transcarbamoylase Toward Trypanosoma Cruzi

ChemMedChem, Volume 21, Issue 6, 27 March 2026.
Aspartate transcarbamoylase (ATC) catalyzes the committed and rate‐limiting step in the pyrimidine de novo biosynthesis pathway. While previously suggested to be a potential target for antimalarial, antitubercular, and antioncologic drug discovery, we hypothesized that an existing compound library of ATC inhibitors designed from one scaffold by ...
Siyao Chen, Monica Cal, Queenie Mondile, Rick Oerlemans, Mukim Mayur Shashikant, Alexander S. S. Dömling, Özlem Tastan Bishop, Pascal Mäser, Matthew R. Groves   +8 more
wiley   +1 more source

Pharmaceutical Cocrystal Development of TAK-020 with Enhanced Oral Absorption

Crystals, 2020
The objective of this study was to improve the solubility of poorly water-soluble drugs by pharmaceutical cocrystal engineering techniques and select the best pharmaceutical forms with high solubility and solubilized formulations for progress from the ...
Kouya Kimoto, Mitsuo Yamamoto, Masatoshi Karashima, Miyuki Hohokabe, Junpei Takeda, Katsuhiko Yamamoto, Yukihiro Ikeda   +6 more
doaj   +1 more source

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Iago C. Vogel, Manuel J. Verganista, Nuno R. Candeias   +2 more
wiley   +1 more source

 Pharmaceutical Cocrystals a Patentable Composition - A Review [PDF]

, 2023
Ramadoss Karthikeyan, Haema Ganapathi, Vijayan Venugopal, Sakthiganapathi Meenatchi Sundaram, S Shanmuganathan, V. Velmurugan   +5 more
openalex   +1 more source

Resolution of a Chiral β‐Aminoketone via Diastereomeric Salt Formation: From Experimental Evidence to Molecular‐Level Insights Into Solution‐Phase Clusters

Chirality, Volume 38, Issue 3, March 2026.
Subtle but significant differences between the heterochiral and homochiral salts during the prenucleation stage, revealed by molecular simulations, are related to the enantiomeric separation of a β‐aminoketone through the precipitation of its corresponding diastereomeric salts. ABSTRACT The classical diastereomeric salt resolution approach was employed
Caterina Momoli, Laura Palombi, Isabella Daidone, Erica Scarel, Massimiliano Aschi   +4 more
wiley   +1 more source