Results 71 to 80 of about 1,824 (206)

Characterizations and Assays of α-Glucosidase Inhibition Activity on Gallic Acid Cocrystals: Can the Cocrystals be Defined as a New Chemical Entity During Binding with the α-Glucosidase?

Molecules, 2020
Cocrystallization with co-former (CCF) has proved to be a powerful approach to improve the solubility and even bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs).
Na Xue, Yutao Jia, Congwei Li, Binnan He, Caiqin Yang, Jing Wang   +5 more
doaj   +1 more source

Analgesic and Antidiarrheal Properties of Lappaconitine, Possibly Through Cyclooxygenase and µ‐Opioid Receptor Interaction Pathways: In Vivo and In Silico Studies

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Lappaconitine (LAP) is a diterpenoid alkaloid with strong anti‐inflammatory activity. However, there is limited information on its gastroprotective effects. The present study aimed to explore the analgesic and antidiarrheal effects of LAP through in vivo and in silico studies.
Shahid Shah, Arifa Akter, Salehin Sheikh, Razina Rouf, Raihan Chowdhury, Jannatul Ferdous, Md. Shimul Bhuia, Imam Hossain Rakib, Md. Zahid Hasan, Siddique Akber Ansari, Irfan Aamer Ansari, Muhammad Torequl Islam   +11 more
wiley   +1 more source

Design, Synthesis, and Evaluation of Naphthyl Pyrazino‐Pyrido‐Pyrimidinones Targeting the Phosphoinositide 3‐Kinase/Alpha‐Serine/Protein Kinase B/Mammalian Target of Rapamycin Pathway

ChemistryOpen, Volume 15, Issue 2, February 2026.
Rationally designed naphthyl pyrazino‐pyrido‐pyrimidinones 3 and 4 inhibited 85%–94% of cancer cell growth. Compound 4 exhibited IC50 = 7.8–12.8 µM with tumor selectivity. Both induced G1 arrest and modulated ULK1, STAT3, alpha‐serine/protein kinase B (AKT), and autophagy via phosphoinositide 3‐kinase/mammalian target of rapamycin (PI3K/mTOR ...
Marcelo F. Marchiori, Gabriel da Silva, Daniel F. Kawano, Andréia M. Leopoldino, Enrique Madruga, Ana Martinez, Ivone Carvalho   +6 more
wiley   +1 more source

The Stoichiometry of TCNQ-Based Organic Charge-Transfer Cocrystals

Crystals, 2020
Organic charge-transfer cocrystals (CTCs) have attracted significant research attention due to their wide range of potential applications in organic optoelectronic devices, organic magnetic devices, organic energy devices, pharmaceutical industry, etc ...
Jiaoyang Gao, Huifei Zhai, Peng Hu, Hui Jiang   +3 more
doaj   +1 more source

De Novo Design and Synthesis of Novel Benzoxazinone Derivatives Targeting Dihydroxyacid Dehydratase

Plant Biotechnology Journal, Volume 24, Issue 2, Page 567-581, February 2026.
ABSTRACT Dihydroxyacid dehydratase (DHAD), a key enzyme in the branched‐chain amino acid (BCAA) synthesis pathway, is a promising herbicide target. Currently, no commercial herbicides target DHAD, and no inhibitors are in development. Structural analysis suggests that coordination with iron–sulfur clusters and hydrophobic interactions with Tyr215 and ...
Bo He, Yanhao Hu, Xu He, Wang Chen, Wei Yan, Xin Zang, Jiahai Zhou, Yonghao Ye   +7 more
wiley   +1 more source

Dynamic Control of Two‐Component Aggregation and Color‐Tunable Emission via Charge‐Transfer Coassembly

Aggregate, Volume 7, Issue 1, January 2026.
Charge‐transfer coassembly enables precise control over the dynamic aggregation process, resulting in morphology evolution from amorphous aggregates to rod‐like and needle‐like microcrystals, accompanied by a significant fluorescence enhancement. This strategy yields widely tunable solid‐state emission from green to orange‐red, unveiling fundamental ...
Huiting Mao, Xinqi Ge, Jiahui Guo, Zhibo Gong, Na Ding, Shijuan Liu, Guo‐Gang Shan, Ruinian Hua   +7 more
wiley   +1 more source

A Review on Pharmaceutical Cocrystals

International Journal of Pharmaceutical Research and Applications
Pharmaceutical cocrystals are crystalline materials composed of two or more different molecules, at least one being an active pharmaceutical ingredient (API), in a fixed stoichiometric ratio, held together by non-covalent interactions.Cocrystal can be prepared by cocrystallization method.
Samina Sameer, Shinta Babu Shinta Babu, Aparna P Aparna P, Dr.Prasobh G R Dr.Prasobh G R   +3 more
openaire   +1 more source

A Proteochemometric Model for Ligands of the SLC5 Transporter Family

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
A novel proteochemometric model was developed to predict the activity and selectivity of SLC5 family inhibitors. The model's performance was validated using 10‐fold cross‐validation on publicly available datasets achieving Q2 = 0.79 and MSE < 0.32. Detailed analysis of the results enabled the identification of a new, previously unrecognized selectivity‐
Martin Juhás, Gerhard Ecker
wiley   +1 more source

Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach

Pharmaceutics, 2020
In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter
Xavier Buol, Koen Robeyns, Camila Caro Garrido, Nikolay Tumanov, Laurent Collard, Johan Wouters, Tom Leyssens   +6 more
doaj   +1 more source

Acemetacin cocrystal structures by powder X-ray diffraction

IUCrJ, 2017
Cocrystals of acemetacin drug (ACM) with nicotinamide (NAM), p-aminobenzoic acid (PABA), valerolactam (VLM) and 2-pyridone (2HP) were prepared by melt crystallization and their X-ray crystal structures determined by high-resolution powder X-ray ...
Geetha Bolla, Vladimir Chernyshev, Ashwini Nangia   +2 more
doaj   +1 more source