Results 1 to 10 of about 574,105 (363)
Pharmaceutical Fronts, 2020 A series of c-Met/histone deacetylase (HDAC) bifunctional inhibitors was designed and synthesized by merging pharmacophores of c-Met and HDAC inhibitors.
Qingwei Zhang +4 more
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Microbial Cell Factories, 2022 Background Acarbose, as an alpha-glucosidase inhibitor, is widely used clinically to treat type II diabetes. In its industrial production, Actinoplanes sp. SE50/110 is used as the production strain.
Zhenxin Li +6 more
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Asymmetric Synthesis of 1,2-Limonene Epoxides by Jacobsen Epoxidation
Pharmaceutical Fronts, 2021 This study reported an asymmetric synthesis of 1,2-limonene epoxides. The absolute stereochemistry was controlled by a Jacobsen epoxidation of cis-1,2-limonene epoxide (with diastereomeric excess of 98%) and trans-1,2-limonene epoxide (with ...
Zi-Yi Huang +5 more
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Pharmaceutical Fronts, 2021 A novel series of quinazoline derivatives were designed, synthesized, and evaluated as multikinase inhibitors. Most of these compounds showed antiproliferation activities of several human cancer cell lines and exhibited inhibition efficacy against the ...
Xiu Gu +5 more
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Pharmacovigilance in the pharmaceutical industry [PDF]
British Journal of Clinical Pharmacology, 1998 Pharmacovigilance has been defined as the process of identifying and responding to drug safety issues [1] and has grown considerably as a discipline over the past 10 to 15 years. An educational survey in 1994 revealed that more than 320 people currently worked in company pharmacovigilance functions in the UK alone [2].
J C, Talbot, B S, Nilsson
openaire +2 more sources
Synthesis and Crystal Structure Analysis of Histone Deacetylase Inhibitor Chidamide
Pharmaceutical Fronts, 2023 Chidamide is the first oral subtype-selective histone deacetylase inhibitor approved in China for the treatment of relapsed and refractory peripheral T cell lymphoma.
Bo Han +4 more
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A Novel and Practical Synthesis of Isavuconazonium Sulfate via Anion Exchange Resin
Pharmaceutical Fronts, 2022 In this study, an efficient and practical process for the synthesis of isavuconazonium sulfate (compound 1), an antifungal agent, was described. Highlights in the synthesis route are the usage of the ion exchange resin instead of H2SO4 to introduce the ...
Lei Huang +5 more
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Scientific Reports, 2023 The single-component colistin E2, with superior antibacterial activity and lower toxicity, was being developed as the latest generation of polymyxin drugs. However, colistin E2 has not been tested quantitatively in biological matrices.
Hongjiang Xu +8 more
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Phenolic Constituents from the Stems of Morus nigra and their α-Glucosidase Inhibitory Activities
Pharmaceutical Fronts, 2021 A new sanggenon-type flavanone, nigragenon F (1), together with 11 known compounds, trans-resveratrol (2), (E)-4-isopentenyl-3,5,2′,4′-tetrahydroxystilbene (3), notabilisin E (4), notabilisin A (5), morusin (6), petalopurpurenol (7), 8-geranyl-5,7 ...
Ling-Ling Wang +5 more
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Pharmaceutical Fronts, 2022 The mometasone furoate (MF) and formoterol fumarate dihydrate (FF) inhalable microparticles prepared by different methods, such as micronized active pharmaceutical ingredients (APIs), microparticles of APIs prepared by spray-freeze drying technique (SFD ...
Quan Xi +3 more
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