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The responsibility of the pharmaceutical industry [PDF]

Clinical Microbiology and Infection, 2001
The pharmaceutical industry plays an active role in policy surrounding the research, discovery and development of new medicines. Along with this commitment, the pharmaceutical industry must also take an active role in helping to ensure that appropriate patients receive access to state-of-the-art scientific advancements.
Calvin B. Durrant
openalex   +3 more sources

The evolving role of investigative toxicology in the pharmaceutical industry

Nature reviews. Drug discovery, 2023
For decades, preclinical toxicology was essentially a descriptive discipline in which treatment-related effects were carefully reported and used as a basis to calculate safety margins for drug candidates.
F. Pognan, M. Beilmann, H. Boonen, A. Czich, Gordon J. Dear, P. Hewitt, T. Mow, Teija Oinonen, A. Roth, T. Steger-Hartmann, J. Valentin, F. van Goethem, R. Weaver, P. Newham   +13 more
semanticscholar   +1 more source

Design, Synthesis, and Biological Evaluation of Dual c-Met/HDAC Inhibitors Bearing 2-Aminopyrimidine Scaffold

Pharmaceutical Fronts, 2020
A series of c-Met/histone deacetylase (HDAC) bifunctional inhibitors was designed and synthesized by merging pharmacophores of c-Met and HDAC inhibitors.
Qingwei Zhang, Guili Xu, Ya Bao, Minru Jiao, Jianqi Li   +4 more
doaj   +3 more sources

Asymmetric Synthesis of 1,2-Limonene Epoxides by Jacobsen Epoxidation

Pharmaceutical Fronts, 2021
This study reported an asymmetric synthesis of 1,2-limonene epoxides. The absolute stereochemistry was controlled by a Jacobsen epoxidation of cis-1,2-limonene epoxide (with diastereomeric excess of 98%) and trans-1,2-limonene epoxide (with ...
Zi-Yi Huang, Min-Ru Jiao, Xiu Gu, Zi-Ran Zhai, Jian-Qi Li, Qing-Wei Zhang   +5 more
doaj   +1 more source

Implementation of the circular supply chain management in the pharmaceutical industry

Environment, Development and Sustainability, 2022
The ever-increasing levels of pollution and waste creation have subjected industries around the world to incorporate the concept of circular economy (CE) in their supply chains.
Feroz Khan, Y. Ali
semanticscholar   +1 more source

Postbiotics: Current Trends in Food and Pharmaceutical Industry

Foods, 2022
Postbiotics are non-viable bacterial products or metabolic byproducts produced by probiotic microorganisms that have biologic activity in the host. Postbiotics are functional bioactive compounds, generated in a matrix during anaerobic fermentation of ...
P. Thorakkattu, Anandu Chandra Khanashyam, Kartik Shah, K. S. Babu, Anjaly Shanker Mundanat, Aiswariya Deliephan, G. Deokar, C. Santivarangkna, N. Nirmal   +8 more
semanticscholar   +1 more source

Enhancement of acarbose production by genetic engineering and fed-batch fermentation strategy in Actinoplanes sp. SIPI12-34

Microbial Cell Factories, 2022
Background Acarbose, as an alpha-glucosidase inhibitor, is widely used clinically to treat type II diabetes. In its industrial production, Actinoplanes sp. SE50/110 is used as the production strain.
Zhenxin Li, Songbai Yang, Zhengyu Zhang, Yuanjie Wu, Jiawei Tang, Luoju Wang, Shaoxin Chen   +6 more
doaj   +1 more source

Discovery of SIPI6473, a New, Potent, and Orally Bioavailable Multikinase Inhibitor for the Treatment of Non-small Cell Lung Cancer

Pharmaceutical Fronts, 2021
A novel series of quinazoline derivatives were designed, synthesized, and evaluated as multikinase inhibitors. Most of these compounds showed antiproliferation activities of several human cancer cell lines and exhibited inhibition efficacy against the ...
Xiu Gu, Zi-Xue Zhang, Min-Ru Jiao, Xin-Yan Peng, Jian-Qi Li, Qing-Wei Zhang   +5 more
doaj   +1 more source

Blockchain technology in the pharmaceutical industry: a systematic review

PeerJ Computer Science, 2022
Blockchain technology is accelerating digital transformation across multiple industries, including the pharmaceutical industry. The pharmaceutical industry suffers from a lack of transparency, difficulty tracking products, lack of trust, and the shipment
N. Zakari, Muna Al-Razgan, Amani M. Alsaadi, H. Alshareef, Heba Al saigh, Lamia Alashaikh, Mala Alharbi, Rana Alomar, Seham Alotaibi   +8 more
semanticscholar   +1 more source

Structure and Applications of Pectin in Food, Biomedical, and Pharmaceutical Industry: A Review

Coatings, 2021
Pectin is a biocompatible polysaccharide with intrinsic biological activity, which may exhibit different structures depending on its source or extraction method.
C. M. P. Freitas, J. Coimbra, V. G. Souza, R. C. S. Sousa   +3 more
semanticscholar   +1 more source