Results 1 to 10 of about 42,622 (74)
Pharmaceutical Fronts, 2020 A series of c-Met/histone deacetylase (HDAC) bifunctional inhibitors was designed and synthesized by merging pharmacophores of c-Met and HDAC inhibitors.
Qingwei Zhang +4 more
doaj +3 more sources
Asymmetric Synthesis of 1,2-Limonene Epoxides by Jacobsen Epoxidation
Pharmaceutical Fronts, 2021 This study reported an asymmetric synthesis of 1,2-limonene epoxides. The absolute stereochemistry was controlled by a Jacobsen epoxidation of cis-1,2-limonene epoxide (with diastereomeric excess of 98%) and trans-1,2-limonene epoxide (with ...
Zi-Yi Huang +5 more
doaj +1 more source
The Impact of the Pharmaceutical Industry on the Innovation Performance of European Countries [PDF]
Regional Statistics, Vol. 13. No. 1. 2023, 2022 There are significant differences in innovation performance between countries. Additionally, the pharmaceutical sector is stronger in some countries than in others. This suggests that the development of the pharmaceutical industry can influence a country's innovation performance.
arxiv +1 more source
Microbial Cell Factories, 2022 Background Acarbose, as an alpha-glucosidase inhibitor, is widely used clinically to treat type II diabetes. In its industrial production, Actinoplanes sp. SE50/110 is used as the production strain.
Zhenxin Li +6 more
doaj +1 more source
Pharmaceutical Fronts, 2021 A novel series of quinazoline derivatives were designed, synthesized, and evaluated as multikinase inhibitors. Most of these compounds showed antiproliferation activities of several human cancer cell lines and exhibited inhibition efficacy against the ...
Xiu Gu +5 more
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Synthesis and Crystal Structure Analysis of Histone Deacetylase Inhibitor Chidamide
Pharmaceutical Fronts, 2023 Chidamide is the first oral subtype-selective histone deacetylase inhibitor approved in China for the treatment of relapsed and refractory peripheral T cell lymphoma.
Bo Han +4 more
doaj +1 more source
A Novel and Practical Synthesis of Isavuconazonium Sulfate via Anion Exchange Resin
Pharmaceutical Fronts, 2022 In this study, an efficient and practical process for the synthesis of isavuconazonium sulfate (compound 1), an antifungal agent, was described. Highlights in the synthesis route are the usage of the ion exchange resin instead of H2SO4 to introduce the ...
Lei Huang +5 more
doaj +1 more source
Scientific Reports, 2023 The single-component colistin E2, with superior antibacterial activity and lower toxicity, was being developed as the latest generation of polymyxin drugs. However, colistin E2 has not been tested quantitatively in biological matrices.
Hongjiang Xu +8 more
doaj +1 more source
Pharmaceutical Fronts, 2022 Clinically available pressurized metered-dose inhalers (pMDIs) mainly directly use micronized drugs as inhalable microparticles. Although technology for preparing pMDIs has proven to obtain clinically appropriate aerosol performance, the fine particle ...
Quan Xi +3 more
doaj +1 more source
Pharmaceutical Fronts, 2022 The mometasone furoate (MF) and formoterol fumarate dihydrate (FF) inhalable microparticles prepared by different methods, such as micronized active pharmaceutical ingredients (APIs), microparticles of APIs prepared by spray-freeze drying technique (SFD ...
Quan Xi +3 more
doaj +1 more source