Results 11 to 20 of about 4,006,128 (388)

A Novel and Practical Synthesis of Isavuconazonium Sulfate via Anion Exchange Resin

open access: yesPharmaceutical Fronts, 2022
In this study, an efficient and practical process for the synthesis of isavuconazonium sulfate (compound 1), an antifungal agent, was described. Highlights in the synthesis route are the usage of the ion exchange resin instead of H2SO4 to introduce the ...
Lei Huang   +5 more
doaj   +1 more source

Synthesis and Crystal Structure Analysis of Histone Deacetylase Inhibitor Chidamide

open access: yesPharmaceutical Fronts, 2023
Chidamide is the first oral subtype-selective histone deacetylase inhibitor approved in China for the treatment of relapsed and refractory peripheral T cell lymphoma.
Bo Han   +4 more
doaj   +1 more source

Applications of Nanomaterials in Agrifood and Pharmaceutical Industry

open access: yesJournal of nanomaterials, 2021
Nanotechnology recently emerged among the most exciting science-related innovations. Nanotechnology-produced metal nanoparticles got a lot of attention.
H. M. Ahmed   +8 more
semanticscholar   +1 more source

A quantitative method for determination of colistin E2 methanesulphonate in human plasma by 15N-labeled colistin E2

open access: yesScientific Reports, 2023
The single-component colistin E2, with superior antibacterial activity and lower toxicity, was being developed as the latest generation of polymyxin drugs. However, colistin E2 has not been tested quantitatively in biological matrices.
Hongjiang Xu   +8 more
doaj   +1 more source

The Study of Spray-Freeze-Drying Technique for Development of Novel Combination pMDIs, Part II: In Vitro and In Vivo Evaluations

open access: yesPharmaceutical Fronts, 2022
The mometasone furoate (MF) and formoterol fumarate dihydrate (FF) inhalable microparticles prepared by different methods, such as micronized active pharmaceutical ingredients (APIs), microparticles of APIs prepared by spray-freeze drying technique (SFD ...
Quan Xi   +3 more
doaj   +1 more source

Phenolic Constituents from the Stems of Morus nigra and their α-Glucosidase Inhibitory Activities

open access: yesPharmaceutical Fronts, 2021
A new sanggenon-type flavanone, nigragenon F (1), together with 11 known compounds, trans-resveratrol (2), (E)-4-isopentenyl-3,5,2′,4′-tetrahydroxystilbene (3), notabilisin E (4), notabilisin A (5), morusin (6), petalopurpurenol (7), 8-geranyl-5,7 ...
Ling-Ling Wang   +5 more
doaj   +1 more source

Enhanced Efficacy and Reduced Hepatotoxicity by Combination of Gnaphalium affine Extract and Benzbromarone in the Treatment of Rats with Hyperuricemic Nephropathy

open access: yesPharmaceutical Fronts, 2021
Simultaneous oral intake of herbal medicine with chemical drugs may result in beneficial pharmacodynamic efficacy, including additive and synergistic effects with reduced toxicity. Gnaphalium affine D. Don (GAD) is a traditional Chinese Medicine that has
Fei Liu   +4 more
doaj   +1 more source

A Perspective on Continuous Flow Chemistry in the Pharmaceutical Industry

open access: yesOrganic Process Research & Development, 2020
Continuous flow manufacture is an innovative technology platform, which is gaining momentum within the pharmaceutical industry.
M. Baumann   +3 more
semanticscholar   +1 more source

Quantitative Study of Impurities in Bedaquiline Fumarate: Identification and Characterization of Its Three Degradation Products Using HPLC, LC/ESI-MS, and NMR Analyses

open access: yesPharmaceutical Fronts, 2023
The study aimed to establish a high-performance liquid chromatography (HPLC) method for the quantitative analysis of the related substances of bedaquiline fumarate. Nuclear magnetic resonance and mass spectrometry were used for characterization and assay.
Xiao-Wen Zhang   +5 more
doaj   +1 more source

A Blockchain and Machine Learning-Based Drug Supply Chain Management and Recommendation System for Smart Pharmaceutical Industry

open access: yesElectronics, 2020
From the last decade, pharmaceutical companies are facing difficulties in tracking their products during the supply chain process, allowing the counterfeiters to add their fake medicines into the market.
Khizar Abbas   +3 more
semanticscholar   +1 more source

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