Results 71 to 80 of about 2,517,866 (353)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Research on the Influence of Tax Incentives on the Innovation Performance of Pharmaceutical Manufacturing Enterprises [PDF]
, 2023 Xia Ouyang, Can Li, Dan Li
openalex +1 more source
FEBS Open Bio, EarlyView.Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel +9 more
wiley +1 more source
BMJ OpenObjectives To assess the upstream pharmaceutical supply chains of 10 high-use pharmaceuticals to detect vulnerabilities that may increase the risk of medicine shortages.Design Cohort study.Setting Dutch outpatient setting in 2022.Participants A total of ...
Aukje K Mantel-Teeuwisse +4 more
doaj +1 more source
Green Processing and Synthesis, 2012 The GSK-Singapore Partnership for Green and Sustainable Manufacturing is a public-private partnership with the objectives of: Enhancing Singapore’s capabilities to address the sustainable manufacturing challenges experienced by the pharmaceutical ...
Dell’Orco Philip +3 more
doaj +1 more source
The other GMP: good manufacturing practice and its importance in the validation of constructed pharmaceutical facilities [PDF]
, 2005 The work reported is part of an ongoing PhD study prompted by the particular difficulties encountered when two very different quality cultures interact (in this case Pharmaceutical industry clients and Construction industry providers).
Edge, Jerry +2 more
core
Patient acceptability, safety and access : A balancing act for selecting age-appropriate oral dosage forms for paediatric and geriatric populations [PDF]
, 2018 © 2017 Elsevier B.V. All rights reserved.The selection and design of age-appropriate formulations intended for use in paediatric and geriatric patients are dependent on multiple factors affecting patient acceptability, safety and access.
Ernest, Terry B. +3 more
core +2 more sources
FEBS Open Bio, EarlyView.CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama +7 more
wiley +1 more source
Inventory drivers in a pharmaceutical supply chain [PDF]
, 2017 In recent years, inventory reduction has been a key objective of pharmaceutical companies, especially within cost optimization initiatives. Pharmaceutical supply chains are characterized by volatile and unpredictable demands –especially in emergent ...
Masvidal Andreu, Clara
core +1 more source
FEBS Open Bio, EarlyView.Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani +7 more
wiley +1 more source