Results 51 to 60 of about 5,230,993 (373)

Potential protective function of the sterol regulatory element binding factor 1–fatty acid desaturase 1/2 axis in early-stage age-related macular degeneration

Heliyon, 2017
Age-related macular degeneration (AMD) is the most common cause of vision loss in elderly individuals throughout the developed world. Inhibitors of vascular endothelial growth factor have been successfully used to treat choroidal neovascularization in ...
Yoshifumi Ashikawa, Yuhei Nishimura, Shiko Okabe, Yumi Sato, Mizuki Yuge, Tomoko Tada, Haruka Miyao, Soichiro Murakami, Koki Kawaguchi, Shota Sasagawa, Yasuhito Shimada, Toshio Tanaka   +11 more
doaj   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Safety of medication use in primary care [PDF]

, 2015
© 2014 Royal Pharmaceutical Society.BACKGROUND: Medication errors are one of the leading causes of harmin health care. Review and analysis of errors have often emphasized their preventable nature and potential for reoccurrence.
Abramson, Abramson, Adubofour, Ahmad, Al Khaja, Al Khaja, Alldred, Alldred, Aronson, Aronson, Ashcroft, Avery, Avery, Avery, Barber, Bayoumi, Berner, Bernstein, Beso, Boockvar, Boockvar, Booij, Braund, Bregnhoj, Britt, Brown, Buurma, Campbell, Carruthers, Chen, Chua, Coleman, Dallenbach, Dean, Dean, Dean, Dean Franklin, Dean Franklin, Department of Health, Department of Health, Department of Health, Devine, Dhabali, Eslami, Field, Fischer, Flynn, Gagne, Gandhi, Gandhi, Gandhi, Garfield, Ghaleb, Ginzburg, Glassman, Green, Gurwitz, Hazlet, Howard, Hume, Humphries, Hämmerlein, Janice O. Olaniyan, Kaushal, Kaushal, Kennedy, Khoja, Knudsen, Knudsen, Kohn, Kuo, Lafata, Lasser, Leape, Lemer, Lewis, Lisby, Lopez-Picazo, Lynskey, Maisoon Ghaleb, Martínez Sánchez, Marwaha, Miller, Moniz, Nanji, Nemeth, Norden-Hagg, Palen, Paul Robinson, Pirmohamed, Raebel, Reason, Royal, Runciman, Sarvadikar, Sayers, Shah, Singh, Soraya Dhillon, Sorensen, Stefanovic, Sweidan, Szczepura, Tam, Tamblyn, Teinilä, Thomsen, Varkey, Vincent, Warholak, Wetzels, Wild, Wong, World Health Organisation   +113 more
core   +1 more source

Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design

FEBS Letters, EarlyView.
Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos, Doriana Ricciuti, Giada Mondanelli, Marco Gargaro   +3 more
wiley   +1 more source

Xoconostle fruit (Opuntia matudae Scheinvar cv. Rosa) by-products as potential functional ingredients [PDF]

, 2015
There is a lack of information on the potential use of xoconostle cultivars as sources of antioxidants for food, pharmaceutical and colorant industries.
Barros, Lillian, Ferreira, Isabel C.F.R., Morales, Patricia, Ramírez-Moreno, Esther, Santos-Buelga, Celestino   +4 more
core   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Pharmacy Curriculum Outcomes Assessment (PCOA) as Predictor of Performance on NAPLEX [PDF]

, 2015
Objectives: The purpose of the study was to respond to students’ inquiry regarding the relationship between student performance on the PCOA administered in early spring of the P3 year and performance on the NAPLEX administered post-graduation.
Hutchinson, David, Lenhard, Lalani, Souza, Jane M.   +2 more
core  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Protein Evolution in Yeast Transcription Factor Subnetworks [PDF]

, 2010
When averaged over the full yeast protein–protein interaction and transcriptional regulatory networks, protein hubs with many interaction partners or regulators tend to evolve significantly more slowly due to increased negative selection. However, genome-
Franzosa, Eric A., Wang, Yong, Xia, Yu, Zhang, Xiang-Sun   +3 more
core   +3 more sources