Results 51 to 60 of about 1,067,890 (357)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Alteration in plasma and striatal levels of d-serine after d-serine administration with or without nicergoline: An in vivo microdialysis study

Heliyon, 2017
Aims: d-Serine (d-Ser), a co-agonist of N-methyl-d-aspartate receptor (NMDAR), is effective for treating schizophrenia. The present study investigated changes in plasma and striatal d-Ser levels in Sprague-Dawley (SD) rats after intraperitoneal d-Ser ...
Mayu Onozato, Hiromi Nakazawa, Katsuyuki Ishimaru, Chihiro Nagashima, Minori Fukumoto, Hitomi Hakariya, Tatsuya Sakamoto, Hideaki Ichiba, Takeshi Fukushima   +8 more
doaj   +1 more source

Patent Trend in Research Centers at Cibinong Science and Technology Park Surrounding for Determining Technology Focus [PDF]

, 2017
. Focusing in a specific technology sector would be a great strategy for early developed Science and Technology Park (STP) especially in Indonesia. Each STP has its own concept considering the resources and technology supply.
Wicaksono, A. (Adityo), Yaniar, H. (Harini)   +1 more
core  

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Currently available murine Leydig cell lines can be applied to study early steps of steroidogenesis but not testosterone synthesis

Heliyon, 2018
Androgen biosynthesis in males occurs to a large extent in testicular Leydig cells. This study focused on the evaluation of three murine Leydig cell lines as potential screening tool to test xenobiotics interfering with gonadal androgen synthesis.
Roger T. Engeli, Cornelia Fürstenberger, Denise V. Kratschmar, Alex Odermatt   +3 more
doaj   +1 more source

Selection Of A Filler For Tablets Manufactured With Direct Compression Method Containing Dry Ginger Extract [PDF]

, 2019
The preliminary studies of physico-chemical and pharmaco-technological properties of the dry extract of ginger have determined the need for introduction of different groups of excipients for developing a solid dosage form for the treatment of type II ...
Alkhalaf, M. (Malek), Gerbina, N. (Nataliia), Ruban, О. (Оlena)   +2 more
core   +3 more sources

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Antibacterial activities of green tea crude extracts and synergistic effects of epigallocatechingallate (EGCG) with gentamicin against MDR pathogens

Heliyon, 2019
Plant extracts and their purified compounds were examined for synergistic antimicrobial activity using selected multi-drug resistant (MDR) pathogens.
Md. Anowar Khasru Parvez, Karabi Saha, Juairia Rahman, Rahath Ara Munmun, Md. Atikur Rahman, Shuvra Kanti Dey, Md. Shahedur Rahman, Sohidul Islam, Mohammad Hossain Shariare   +8 more
doaj   +1 more source

2018 High Sierra Leadership Expedition [PDF]

, 2018
STEP Category: Leadership2018 High Sierra Leadership Expedition Presentation by Lauren Kobasuk.The Ohio State University Second-year Transformational Experience Program (STEP)Academic Major: Pharmaceutical ...
Kobasuk, Lauren
core  

India and the Patent Wars: Pharmaceuticals in the New Intellectual Property Regime [PDF]

, 2017
[Excerpt] India and the Patent Wars contributes to an international debate over the costs of medicine and restrictions on access under stringent patent laws showing how activists and drug companies in low-income countries seize agency and exert ...
Halliburton, Murphy
core   +2 more sources