Results 51 to 60 of about 333,294 (298)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Survey of the pattern of antibiotic dispensing in private pharmacies in Nepal

BMJ Open, 2019
Objectives Private pharmacies are widely established in most low/middle-income countries (LMICs) including Nepal, and are often considered as a patient’s first point of contact for seeking healthcare.
Anant Nepal, D. Hendrie, Suzanne Robinson, L. Selvey   +3 more
semanticscholar   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Perceptions and trends in the use of community pharmacies in Ghana

Journal of Pharmaceutical Policy and Practice, 2019
To examine the patterns in utilization of community pharmacies and perceptions of the general public towards community pharmacists’ role in health services delivery. A cross-sectional household survey was conducted in Ga West district.
Grace Adjei Okai, G. Abekah‐Nkrumah, P. Asuming   +2 more
semanticscholar   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Assessment of pharmacists’ knowledge, attitude and practice in chain community pharmacies towards their current function and performance in Indonesia

Pharmacy in practice, 2019
Background: The introduction of universal healthcare coverage in 2014 has affected the practice of community pharmacies in Indonesia. Studies regarding the practice of pharmacist in the chain community pharmacy setting in Indonesia are very limited.
U. Athiyah, C. D. Setiawan, G. Nugraheni, E. Zairina, Wahyu Utami, Andi Hermansyah   +5 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Development of pharmacy competency framework for the changing demands of Thailand’s pharmaceutical and health services

Pharmacy Practice, 2020
Background: In Thailand, pharmacists are responsible for all activities to ensure access to medicines throughout pharmaceutical supply chain. Competency framework (CF) is an important guidance for professional development and workforce planning ...
Puckwipa Suwannaprom , Siritree Suttajit , Suntara Eakanunkul , Teeraporn Supapaan , Nusaraporn Kessomboon , Khunjira Udomaksorn , Rungpetch Sakulbumrungsil   +6 more
doaj   +1 more source

Knowledge, attitude and practice of community pharmacy personnel in tuberculosis patient detection: a multicentre cross-sectional study in a high-burden tuberculosis setting [PDF]

, 2022
Ivan Surya Pradipta, Khairunnisa Khairunnisa, Muh. Akbar Bahar, Mersa Nurain Kausar, Efi Fitriana, Rovina Ruslami, Rob E. Aarnoutse, Rizky Abdulah   +7 more
openalex   +1 more source

Prescription and non-prescription antibiotic dispensing practices in part I and part II pharmacies in Moshi Municipality, Kilimanjaro Region in Tanzania: A simulated clients approach

PLoS ONE, 2018
Antibiotic dispensing without a prescription poses a threat to public health as it leads to excessive antibiotic consumption. Inappropriate antibiotic availability to the community has been documented to be amongst drivers of antimicrobial resistance ...
P. Horumpende, Tolbert B. Sonda, Marco van Zwetselaar, Magreth L Antony, F. Tenu, Charles E Mwanziva, E. Shao, S. Mshana, B. Mmbaga, J. Chilongola   +9 more
semanticscholar   +1 more source