Results 51 to 60 of about 71,068 (268)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Chemometrically-supported quality assessment of chamomile tea
Acta PharmaceuticaThe quality of chamomile (Matricaria recutita) is largely determined by its content of essential oils and flavonoids, the main pharmacologically active constituents.
Blažeković Biljana +4 more
doaj +1 more source
JAMA: The Journal of the American Medical Association, 1905 It is rather a peculiar feature of life that some of the best advice we get is from those who know the least of what we do. The charming sarcasm of Pinafore in the representation of Sir Joseph Porter, K.C.G., at the head of the British Admiralty is only excused by the truthfulness of the application. Many of our great secretaries of war and of the navy
openaire +2 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
USING THE MODEL VIEW CONTROLLER (MVC) METHOD IN MEDICAMENT SALES INFORMATION SYSTEM DESIGN
Jurnal Riset Informatika, 2020 Sales have an important role in an organization, especially medicament sales at Pharmacies, especially at Apotik Bubulak Bogor. The use of a good information system is certainly very necessary for the Pharmacy to manage its data.
Nur Hidayati
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Exploring the Distribution System of Herbal Medicine from the Perspective of Purchases and Orders Managers in the Pharmacies in Tehran and Qom: A Qualitative Study [PDF]
Taṣvīr-i salāmat, 2019 Background and Objectives: Because of the increased using of herbal medicines, these drugs are becoming vital. By reviewing Iran’s drug supply chain, we find out consumers have less knowledge about the type of drug and its manufacturer, therefore ...
Ali Abedini +2 more
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