Results 91 to 100 of about 263,791 (359)

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

The Conscience of a Pharmacist [PDF]

American Journal of Pharmaceutical Education, 2019
The purpose of this commentary is to attempt to provide some insight into conscience-clause cases from the perspective of a pharmacist and an academician. Health professionals, including pharmacists, have a social contract with the patients we serve in which the patients give us a level of status not given to non-professionals, and, in return, we agree
openaire   +3 more sources

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

The switch from patented medicine to the generic one: an option or a necessity? [PDF]

, 2018
This paper assesses the influence of a number of factors taken into account when a brand name drug is replaced by a generic one. It also evaluates responses of health professionals – physicians and pharmacist—and patients regarding the issue of switching.
Adriana Elena, Nica, Alexandra, Bolocan, Dan Nicolae, Păduraru, Daniel, Ion, Dumitru Cristinel, Badiu, Florentina, Coman, Marius, Coțofană, Octavian, Andronic, Valentin Titus, Grigorean   +8 more
core   +1 more source

Method of Stimulation of Pharmacy Workers Involved in the Government Program “Available Medicines” [PDF]

, 2019
The aim is to study the current state of the organization of work in pharmacies under the government program “Available medicines” and to create proposals for the improvement of material incentives to increase the motivation of workers of such pharmacies.
Moroz, S. (Svitlana), Nemchenko, A. (Alla), Podgaina, M. (Maryna), Vynnyk, O. (Olena), Zoidze, D. (Diana)   +4 more
core   +3 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Geriatric pharmacotherapy : optimisation through integrated approach in the hospital setting [PDF]

, 2016
Since older patients are more vulnerable to adverse drug-related events, there is a need to ensure appropriate prescribing in these patients in order to prevent misuse, overuse and underuse of drugs.
A Corsonello, A Jha, A Leendertse, A Somers, A Somers, A Somers, A Spinewine, A Spinewine, A Spinewine, American Geriatrics Society, B Basger, B Berenguer, B Lund, B Strom, B Tangiisuran, C Lindley, C Naugler, C Rancourt, C Scullin, C Zhan, D Classen, E Hajjar, G Batty, G Ellis, G Onder, G Onder, G Onder, G Onder, H Beijer, H Hamilton, I Eland, J Hanlon, J Hanlon, J Klopotowska, J Lazarou, J Schnipper, J Wolfstadt, K Perehudoff, K Schmader, L Leape, M Beers, M Laroche, M O’Connor, M Passarelli, M Petrovic, M Petrovic, M Pirmohamed, M Steinman, NS Wenger, P Bemt van den, P Gallagher, P Gallagher, P Lampela, P McLeod, P Rochon, R Cipolle, R Page, S Holt, S Kaur, S Kucukarslan, S Rognstad, T Field, T Field, W Winit-Watjana   +63 more
core   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

A communication protocol between community pharmacists and primary care professionals to solve patients´ medication problems

International Journal of Integrated Care, 2019
Introduction: Communication between health professionals (HP) is a key issue to enhance quality and efficiency of health care system. (1,2). Community pharmacists (CPs) are often not integrated in the current HP communication model.
Ainhoa Oñatibia-Astibia, Belen Larrañaga, Josune Iribar, Arritxu Etxebarria, Nekane Odriozola, Miguel Ángel Gastelurrutia, Ana Bustinduy, Estibaliz Goyenechea   +7 more
doaj   +1 more source

Investigating and learning lessons from early experiences of implementing ePrescribing systems into NHS hospitals:a questionnaire study [PDF]

, 2013
Background: ePrescribing systems have significant potential to improve the safety and efficiency of healthcare, but they need to be carefully selected and implemented to maximise benefits.
A Black, A Jha, A Majeed, A Robertson, A Robertson, A Sheikh, AJ Avery, Ann Slee, AS Kesselheim, Aziz Sheikh, B Fernando, BL Strom, C Huckvale, CJ Morris, D Blumenthal, DH Smith, DW Bates, E Ammenwerth, E Coiera, EE Roughead, FS Mair, J Hendy, Jamie Coleman, JI Westbrook, Johanna I. Westbrook, JS Ash, K Cresswell, K Cresswell, Kathrin Cresswell, KM Cresswell, L Catwell, M Pirmohamed, M Reckmann, N Mays, N Pollock, R Kaushal, R Koppel, Robin Williams, S Crowe, S Schneeweiss, T Greenhalgh, T Greenhalgh, Z Morrison   +42 more
core   +3 more sources