Results 121 to 130 of about 186,636 (307)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Point-of-care testing of cardiovascular risk factors in Viennese community pharmacies: A cross-sectional study

Preventive Medicine Reports
Objective: Despite being the leading contributor to global mortality, cardiovascular diseases remain undetected in many individuals at-risk. The aim of this study was to evaluate the proportion of individuals with unrecognised cardiovascular risk factors
Thorsten Bischof, Viktoria Mair, Alexander Schmidt-Ilsinger, Philipp Saiko, Susanne Ergott-Badawi, Bernd Jilma, Stefan Deibl, Christian Schoergenhofer   +7 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Voluntary information and price sharing database – a scoping review of the pricing and procurement landscape across eight Commonwealth Member States

Journal of Pharmaceutical Policy and Practice
Background The Commonwealth Health Ministers’ meetings (2021–2023) identified medicines shortages, pricing, and price transparency as critical issues. This led to the establishment of the Voluntary Information and Price Sharing Database (VIPSD) in 2021 ...
Bridget Kebirungi, Phyllis Ocran, Nduta Kamere, Lynette Keneilwe Mabote, Ngozi Osi, Meghna Joshi-von Heyden, Emily Gilmour, Janneth Mghamba, Layne Robinson, Zaheer-Ud-Din Babar, Helena Rosado, Victoria Rutter   +11 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

PHARMACISTS AS IMMUNIZERS IN NOVA SCOTIA, CANADA: IDENTIFYING IMMUNIZATION PRESCRIBING TRENDS AND PATIENT CHARACTERISTICS

, 2023
The study objectives were to 1.) describe demographic characteristics of individuals prescribed immunizations by pharmacists in Nova Scotia, comparing characteristics pre- and during COVID-19 and against the provincial population; and 2.) describe ...
Lawrence, Rebecca
core  

Project IMPACT: Test and Treat. Increasing access to Test and Treat services through community pharmacy

INNOVATIONS in Pharmacy
Background: Community pharmacists are able to provide patients with access to high-quality Test and Treat services for respiratory illness utilizing innovative rapid molecular diagnostic tests, and to prescribe medication treatment when appropriate ...
Jonathan Little, Benjamin Bluml, Ambarish Ambegaonkar, Dhanish Revanth   +3 more
doaj  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source