Results 101 to 110 of about 162,217 (316)

Psychosocial factors associated with pharmacists’ antidepressant drug treatment monitoring.

, 2020
Objective: Patients undergoing antidepressant drug treatment (ADT) may face challenges regarding its adverse effects, adherence, and efficacy. Community pharmacists are well positioned to manage ADT-related problems.
Guillaumie, Laurence, Grégoire, Jean-Pierre, Lauzier, Sophie, Moisan, Jocelyne, Villeneuve, Denis, Humphries, Brittany   +5 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Do community pharmacists have the attitudes and knowledge to support evidence based self-management of low back pain?

, 2007
Background In many countries, community pharmacists can be consulted without appointment in a large number of convenient locations. They are in an ideal position to give advice to patients at the onset of low back pain and also reinforce advice given by
Moffett Jennifer, Moffett, Jennifer Klaber, Silcock Jonathan, Silcock, Jonathan, Waddell Gordon, Gordon Waddell, Hilary Edmondson, Burton, A. Kim, A Kim Burton, Burton A Kim, Edmondson, Hilary, Jonathan Silcock, Edmondson Hilary, Jennifer Klaber Moffett, Moffett, Jennifer, Waddell, Gordon   +15 more
core   +1 more source

Effects of a community pharmacy-based structured medication review on drug-related problems in all-comers with polypharmacy: a randomized, controlled, double-blind, parallel-group trial

Frontiers in Medicine
BackgroundMedication reviews may help to reduce the burdens of polypharmacy. A medication review type 2a is a structured evaluation of a patient’s pharmacotherapy based on medication history and patient information in a face-to-face interview.MethodsThis
Thorsten Bischof, Alexander Schmidt-Ilsinger, Magdalena Hoppel, Anton Kreuzer, Stefanie Briganser, Philipp Saiko, Susanne Ergott-Badawi, Raimund Podroschko, Stephan Moser, Michael Kossmeier, Bernd Jilma, Stefan Deibl, Christian Schoergenhofer   +12 more
doaj   +1 more source

Pharmacist-led medication reviews for geriatric residents in German long-term care facilities

BMC Geriatrics, 2019
Background The benefit of medication reviews for long-term care (LTC) residents has been generally recognized throughout health care systems. Whereas many studies showed the impact of comprehensive medication reviews performed by specialized clinical ...
Kerstin Bitter, Christina Pehe, Manfred Krüger, Gabriela Heuer, Regine Quinke, Ulrich Jaehde   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Marketing for 'pharmacists', not 'pharmacies'.

, 2012
For decades we have seen the dynamics of what “pharmacies” think they have to offer and “pharmacists” have been engrossed (some would say lost!) in that mix.
Woods, Phillip Stephen
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source