Results 81 to 90 of about 162,217 (316)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Clinician Attitudes Toward Referring Patients to Pharmacists for Tobacco Cessation Services [PDF]

open access: yes
Background The role of pharmacists in tobacco cessation has grown substantially in recent years, now including the ability to prescribe medications in many states.
Corelli, Robin L.   +8 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Characteristics of pharmacists, United States [PDF]

open access: yes
Demographic and employment characteristics of licensed pharmacists in 1978-79 are described. Information is presented on their geographic distribution and supply, their practice settings, the number of hours and weeks worked, and the attraction of women ...

core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Perceptions and experiences of reporting of adverse drug reactions by public sector pharmacists in a rural district in the Western Cape [PDF]

open access: yes, 2016
Magister Public Health - MPHBackground: Adverse Drug Reactions (ADRs) contribute to potentially expensive hospital admissions and are regarded as a major public health priority.
Williams, Charles
core  

Use of and familiarity with dietary supplement information references by practicing pharmacists.

open access: yes, 2008
Click on the Resource Link to access the article (may not be free).Objective: To survey practicing pharmacists regarding their use of and familiarity with six dietary supplement information references.
Cerulli, Jennifer, Zeolla, Mario M
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Clinical efficacy of baloxavir marboxil versus oseltamivir in kidney transplant recipients with influenza

open access: yesMicrobiology Spectrum
Kidney transplant recipients (KTRs) are at high risk for severe influenza and its complications. The effectiveness of baloxavir marboxil (hereafter baloxavir) in infected KTRs is still unknown.
Jiali Jiang   +8 more
doaj   +1 more source

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