Results 91 to 100 of about 162,217 (316)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

An examination of the comparative ability of primary care health professionals in the recognition and treatment of a range of dermatological conditions

, 2013
Background Recent data suggest that skin problems were the most common reason for patients visiting their GP in the UK. Healthcare professionals such as practice nurses and community pharmacists represent potential alternative sources of advice for ...
Walton, Shernaz, Tucker, Rod, Tucker, R., Alison L Layton, Layton, Alison, Layton, Alison L., Rod Tucker, Mahendra Patel, Patel, Mahendra, Shernaz Walton   +9 more
core   +1 more source

Feasibility and acceptability of an overdose prevention intervention delivered by Community Pharmacists for patients prescribed opioids for chronic non-cancer pain

, 2023
There have been increases in the prescribing of high strength opioids for chronic non-cancer pain (CNCP) but CNCP patients perceive themselves as being at low risk of opioid overdose and generally have limited overdose awareness.
Tessa Parkes, Andrew McAuley, Alexander Baldacchino, Steele, Wez, Kristina Hnízdilová, McAuley, Andrew; id_orcid, Catriona Matheson, Foster, Rebecca, Mercer, Fiona, Hnízdilovà, Kristina, Parkes, Tessa, Wez Steele, Raeburn, Fiona, Fiona Mercer, Baldacchino, Alexander, Joe Schofield, Rebecca Foster, Matheson, Catriona, Hnízdilová , Kristina, Fiona Raeburn, Schofield, Joe, McAuley, Andrew, Lucy Skea, Skea, Lucy   +23 more
core   +1 more source

Potential clinical impact of pharmaceutical interventions in an interprofessional medication management program

Exploratory Research in Clinical and Social Pharmacy
Introduction: Medication reviews (MR) can improve medication safety, especially when followed by continuous medication management (MM). The interprofessional MM program ARMIN resulted in a significantly reduced mortality risk.
Christiane Eickhoff, Ann Kathrin Strunz, Maike Petersen, Meike Ruschkowski, Uta Müller, Martin Schulz   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Hospital pharmacists' views on collaborative pharmacist prescribing

, 2013
In 2008, Weeks et al. published the results of a postal survey, which explored the views of the Society of Hospital Pharmacists of Australia’s (SHPA) members on collaborative prescribing, and the extent of de facto prescribing in their institution. Since
Coombes, Ian, Nissen, Lisa, Hale, Andrew
core   +1 more source

The Conscience of a Pharmacist [PDF]

American Journal of Pharmaceutical Education, 2019
The purpose of this commentary is to attempt to provide some insight into conscience-clause cases from the perspective of a pharmacist and an academician. Health professionals, including pharmacists, have a social contract with the patients we serve in which the patients give us a level of status not given to non-professionals, and, in return, we agree
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Pharmacists face legal burden

, 2007
The changing practice of pharmacy has the potential to impact on the legal liability of pharmacists. This is because of a bigger focus on the provision of patient care services.
Hattingh, Laetitia
core