Results 121 to 130 of about 181,985 (340)

Modern Ideas on the Teaching of Therapeutics and Pharmacodynamics [PDF]

, 1909
MAURICE VÈJUX TYRODE
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Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Reduced oxycodone brain delivery in rats due to lipopolysaccharide-induced inflammation: microdialysis insights into brain disposition and sex-specific pharmacokinetics

Fluids and Barriers of the CNS
Background Oxycodone, a widely used opioid analgesic, has an unbound brain-to-plasma concentration ratio (Kp,uu) greater than unity, indicating active uptake across brain barriers associated with the putative proton-coupled organic cation (H+/OC ...
Frida Bällgren, Margareta Hammarlund-Udenaes, Irena Loryan   +2 more
doaj   +1 more source

Procyanidin B3 and Its Derivatives Alleviate Neuronal Injury by Targeting G3BP1 for Ischemic Stroke Therapy

Advanced Science, EarlyView.
Ischemic stroke is a serious disease with high rates of mortality and disability, but there is a lack of novel therapeutic targets and agents for it. Now it is shown that Ras GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1) has the potential to serve as a therapeutic target for ischemic stroke.
Heyanhao Zhang, Yuyu Zhang, Yibo Chen, Wen Zhong, Subei Tan, Jinghuan Wang, Huanren Yan, Ning Yan, Mengjia Lin, Xinhua Liu, Jun Chang   +10 more
wiley   +1 more source

Active CNS delivery of oxycodone in healthy and endotoxemic pigs

Fluids and Barriers of the CNS
Background The primary objective of this study was to advance our understanding of active drug uptake at brain barriers in higher species than rodents, by examining oxycodone brain concentrations in pigs.
Frida Bällgren, Tilda Bergfast, Aghavni Ginosyan, Jessica Mahajan, Miklós Lipcsey, Margareta Hammarlund-Udenaes, Stina Syvänen, Irena Loryan   +7 more
doaj   +1 more source

An introduction to chemical pharmacology. Pharmacodynamics in relation to chemistry [PDF]

, 1921
Henry Leffmann
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EM2, a Natural Product MST1/2 Kinase Activator, Suppresses Non‐Small Cell Lung Cancer via Hippo Pathway Activation

Advanced Science, EarlyView.
EM2 directly binds to and activates MST1/2, enhancing their kinase activity and sequentially promoting LATS phosphorylation, which increases YAP phosphorylation. Consequently, YAP nuclear translocation is suppressed, leading to reduced transcription of downstream targets CTGF and CYR61, ultimately exerting a robust inhibitory effect on NSCLC cell ...
Siyu Yang, Huayan Xie, Qiang Lin, Liujin Zhou, Junxi Liu, Zekai Fang, Ziling Tang, Ruijie Yuan, Jinxuan Su, Sijia Li, Wenlin Wang, Mingyu Pan, Hao Wang, Xiaoyong Dai, Guocai Wang, Yubo Zhang   +15 more
wiley   +1 more source

Capillary Electrophoresis-Laser Induced Fluorescence Method Development and Validation for Quantification of Nine Gangliosides—Application to Analysis of Cell Lines of CNS Origin

Molecules
Gangliosides are sialic acid-containing glycosphingolipids that play an essential role in many biological and pathophysiological processes. They are present in high amounts in the central nervous system and their abnormal metabolism or expression has ...
Katinka Tarnóczi, Orsolya Geda, Tamás Tábi, Éva Szökő   +3 more
doaj   +1 more source

Acute Pharmacodynamic Effects of Glucocorticoids [PDF]

, 1965
Mohinder P. Sambhi, Max Harry Weil, Vasant N. Udhoji   +2 more
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High‐Throughput Strategies for Streamlining Lipid Nanoparticle Development Pipeline

Advanced Science, EarlyView.
This review highlights emerging state‐of‐the‐art high‐throughput strategies for optimising lipid nanoparticle formulation. By integrating combinatorial design, characterization, in vitro/in vivo screening, automation, and machine learning into a closed‐loop framework, it provides a roadmap to streamline discovery and accelerate the translation of ...
Lois Lam, Stephanie Watson, Yogambha Ramaswamy, Gurvinder Singh   +3 more
wiley   +1 more source