Results 151 to 160 of about 187,044 (318)

Skeletal Muscle Biomarkers of Amyotrophic Lateral Sclerosis: A Large‐Scale, Multi‐Cohort Proteomic Study

Annals of Neurology, EarlyView.
Objective Biomarkers with clear contexts of use are important tools for amyotrophic lateral sclerosis (ALS) therapy development. Understanding their longitudinal trajectory in the untreated state is key to their use as potential markers of pharmacodynamic response.
Oleksandr Dergai, Joanne Wuu, Magdalena Koziczak‐Holbro, Andrea Malaspina, Volkan Granit, Jessica P. Hernandez, Anne Cooley, Ruchika Sachdev, Lili Yu, Michael Bidinosti, Ludivine Flotte, Mark Nash, Lori L. Jennings, James D. Berry, Lucie I. Bruijn, Sophie Brachat, Michael Benatar   +16 more
wiley   +1 more source

Pharmacodynamics [PDF]

, 2020
openaire   +2 more sources

P0197 Comparison of pharmacodynamic and mechanistic response of guselkumab intravenous and subcutaneous induction in moderately to severely active Crohn’s disease: molecular analysis of the GRAVITI and GALAXI Phase 3 studies [PDF]

Dylan Richards, Rickesh N. Patel, Kyung-Ah Sohn, Ailsa Hart, Tong Lee, J Liu, Cara Sisk, Mobolaji Olurinde, Natalie A. Terry, Bradford L. McRae, Walter Reinisch, B Feagan, Flavio Steinwurz, Remo Panaccione, Geert D’Haens, Patrick Branigan   +15 more
openalex   +1 more source

3D Hydrogel Cell Cultures and Their Biomedical Applications

Advanced NanoBiomed Research, EarlyView.
The review highlights the advantages of hydrogel‐based 3D cell cultures over traditional 2D models. These hydrogels closely mimic natural cellular environments, improving research in tissue engineering, drug discovery, cancer studies, and neuroscience.
Tri Lan Thai, Arushi Manchanda, Sarah L. Higginbottom, Estrella Sanz Rodriguez, Richard Wilson, Eva Tomaskovic‐Crook, Jeremy M. Crook, Brett Paull   +7 more
wiley   +1 more source

Pharmacokinetics and pharmacodynamics of everolimus in patients with renal angiomyolipoma and tuberous sclerosis complex or lymphangioleiomyomatosis [PDF]

, 2015
Klemens Budde, Bernard A. Zonnenberg, Michael Frost, Wing K. Cheung, Shweta Urva, Thomas Brechenmacher, Karen Stein, David Chen, J.C. Kingswood, John J. Bissler   +9 more
openalex   +1 more source

Pharmacokinetics and Pharmacodynamics of Salvinorin A and Salvia divinorum: Clinical and Forensic Aspects [PDF]

, 2021
Andreia Machado Brito-da-Costa, Diana Dias da Silva, Nelson G. M. Gomes, Ricardo Jorge Dinis‐Oliveira, Áurea Madureira-Carvalho   +4 more
openalex   +1 more source

Emergence of Staphylococcus aureus Resistance to Antimicrobial Peptides Nisin, NZ2114 and Bacitracin Involves Multiple Phenotypic Changes

Animal Research and One Health, EarlyView.
The AMP‐induced mutant Staphylococcus aureus strain nzR showed increased resistance, five gene mutations, and decreased surface anion levels. AMPs affect the NDH‐2 protein encoded by ndh gene inhibiting the growth of S. aureus. The deletion of the ndh gene promotes the development of AMPs resistance.
Lingyu Xiao, Xingyuan Ma, Ping Tian, Lianbin Li, Zafir Muhammad, Xiaokun Wang, Xuemei Xue, Jinhe Xiao, Liangjun Zheng, F. A. El‐Gohary, Xin Zhao, Junning Pu, Huping Xue   +12 more
wiley   +1 more source

Revealing the potential bioactive components and mechanism of Qianhua Gout Capsules in the treatment of gouty arthritis through network pharmacology, molecular docking and pharmacodynamic study strategies [PDF]

Gelin Xiang, Luyin Yang, Jing Qin, Shaohui Wang, Yi Zhang, Sijin Yang   +5 more
openalex   +1 more source

Dose Optimization in Oncology Drug Development: The Emerging Role of Pharmacogenomics, Pharmacokinetics, and Pharmacodynamics [PDF]

, 2023
Apostolos Papachristos, Jai N. Patel, Maria Vasileiou, George P. Patrinos   +3 more
openalex   +1 more source

Pharmacokinetic principles [PDF]

, 2006
De Paepe, Peter, Kalmar, Alain, Struys, Michel   +2 more
core   +1 more source