Results 71 to 80 of about 181,985 (340)

Pharmacokinetics and pharmacodynamics of fluoroquinolones [PDF]

Clinical Microbiology and Infection, 1998
'Division of Clinical Pharmacology, Department of Medicine, Albany Medical College, Albany, New York, USA; 21NSERM U479, Service d'Hematologie et d'Immunologie Biologiques, CHU Xavier BICHAT, Paris, France; 3Department of Infectious Diseases, Uppsala University Hospital, Uppsala, Sweden; 4Hoechst Marion Roussel Inc, Bridgewater, New Jersey, USA; 5Med ...
Marie-Thérèse Labro, Willi Weber, Fritz Sörgel, George L. Drusano, Paul Mendes, Otto Cars, Pramod M. Shah   +6 more
openaire   +3 more sources

Profile of sugammadex for reversal of neuromuscular blockade in the elderly: Current perspectives [PDF]

, 2017
The number of elderly patients is increasing worldwide. This will have a significant impact on the practice of anesthesia in future decades. Anesthesiologists must provide care for an increasing number of elderly patients, who have an elevated risk of ...
Bertoncello, Francesco, Carron, Michele, Ieppariello, Giovanna   +2 more
core   +1 more source

Body Biofluids for Minimally‐Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentralized monitoring, using alternative body biofluids.
Lanka Tata Rao, Chandan Kumar Mandal, Fernando Patolsky   +2 more
wiley   +1 more source

Acute neuroendocrine challenge elicits enhanced cortisol response and parallel transcriptomic changes in patients with migraine

PAIN Reports
. Introduction:. Migraine is a neurological disorder with recurrent attacks characterized by headaches and sensitivity to stimuli. Stress is a significant trigger for attacks; however, molecular mechanisms of the connection are poorly understood ...
Sahel Kumar, Peter Petschner, Kinga Gecse, Dora Torok, Gabriella Juhasz   +4 more
doaj   +1 more source

Evaluating predictive pharmacogenetic signatures of adverse events in colorectal cancer patients treated with fluoropyrimidines [PDF]

, 2013
The potential clinical utility of genetic markers associated with response to fluoropyrimidine treatment in colorectal cancer patients remains controversial despite extensive study.
A Fariña-Sarasqueta, A Loganayagam, A Ruzzo, A Ruzzo, A Yawata, A Zaniboni, Andreas-Claudius Hoffmann, Ann Barrett, B Glimelius, BA Jennings, Barbara A. Jennings, C Fernandez-Rozadilla, C Zhang, CE de Bock, CF Thorn, D Caronia, Daniel Epurescu, DB Longley, E Hitre, E Van Cutsem, G Willis, Gavin S. Chu, Gavin Willis, H Gellekink, H Taflin, I Weisberg, J Cassidy, Jane Skinner, K Derwinger, K Kawakami, K Kawakami, L Peter, L Sharp, M Boisdron-Celle, M Gusella, M Scartozzi, M Schwab, M Vignoli, ME Fernández-Contreras, Melanie Keane, MJ Deenen, MS Braun, MV Mandola, MV Mandola, MV Mandola, N Horie, P Frosst, R Pullmann Jr., RA Goodwin, Richard Turner, S Afzal, S Afzal, S Kaneda, T André, TV Perneger, V Sulzyc-Bielicka, W Ichikawa, W Scheithauer, WG Johnson, Yoon K. Loke   +59 more
core   +3 more sources

Methotrexate‐Loaded Liposomal Formulation Enables 6‐Week Sustained Intraocular Therapeutic Drug Release in a Porcine Model

Advanced Healthcare Materials, EarlyView.
A liposomal formulation for methotrexate enables minimally invasive, sustained intraocular drug delivery for over six weeks with a single injection. Developed for treating intraocular diseases like lymphoma and PVR, it offers excellent biocompatibility in vivo in a porcine model.
Maximilian Hammer, Lea Skrzypczyk, Sabrina Wohlfart, Bryan Calder Ackermann, Ludwig Geisweid, Simon William Pohl, Margarita Karaivanova, Jonathan Herth, Victor Aristide Augustin, Alexander Studier‐Fischer, Tina Sackmann, Leon Kaulen, Anna Steyer, Walter Mier, David H Steel, Kanmin Xue, Gerd Uwe Auffarth, Philipp Uhl   +17 more
wiley   +1 more source

Pharmacodynamics in hypothermia [PDF]

Critical Care, 2012
Guidelines for using inotropic drugs to support cardiovascular function at low core temperatures are not well characterized. The safe application of inotropic drugs during normothermic conditions, routinely used to treat cardiovascular instability by effectively increasing cardiac output (CO) and improve end-organ perfusion associated with acute heart ...
openaire   +2 more sources

Supervised versus unsupervised antimalarial treatment with six-dose artemether-lumefantrine: pharmacokinetic and dosage-related findings from a clinical trial in Uganda. [PDF]

, 2006
BACKGROUND: A six-dose antimalarial regimen of artemether-lumefantrine (A/L) may soon become one of the most widely used drug combination in Africa, despite possible constraints with adherence and poor absorption due to inadequate nutrition, and a lack ...
Babigumira, J, Bajunirwe, F, Biraro, S, Checchi, F, Ferradini, L, Fogg, C, Grandesso, F, Guthmann, J P, Kigozi, I, Kiguli, J, Kyomuhendo, J, Piola, P, Ruzagira, E, Taylor, W R J   +13 more
core   +3 more sources

Natural Sweetener Stevioside‐Based Dissolving Microneedles Solubilize Minoxidil for the Treatment of Androgenic Alopecia

Advanced Healthcare Materials, EarlyView.
This study addresses limitations of minoxidil (MXD) in treating androgenetic alopecia by using stevioside (STV) as a solubilizing agent and microneedle (MN) material. STV enhanced MXD's solubility and skin absorption, leading to improved drug delivery and significant hair regrowth in animal models, demonstrating strong potential for AGA treatment ...
Junying Zhang, Tianyu Shao, Hailiang Li, Luying Zhu, Lamyaa Albakr, Nial J. Wheate, Lifeng Kang, Chungyong Wu   +7 more
wiley   +1 more source

Personalizing HIV therapy, mission impossible? [PDF]

, 2012
Sustained HIV suppression depends on a number of factors including therapy adherence, management of side effects, viral resistance and individual characteristics of patients and therapeutic settings.
Hentig, Nils von
core   +1 more source