Results 61 to 70 of about 34,898 (217)
British Journal of Clinical Pharmacology, EarlyView.Aims Amoxicillin, a widely used β‐lactam antibiotic, requires improved pharmacokinetic characterization during breastfeeding. This study used a population pharmacokinetic (PopPK) approach to model amoxicillin concentrations in breast milk, identify variability sources and estimate infant exposure, applying worst‐case scenarios.
Sarah Baklouti +9 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim The aim of this study was to assess the general and product‐specific experiences of MAHs use of RWD/RWE in medicines development and in their regulatory submissions, and to explore organizational aspects of MAHs related to RWD/RWE. Methods An electronic survey was conducted, and information collected directly from MAHs.
Sini M. Eskola +5 more
wiley +1 more source
Pharmacogenetic CYP2B6 variants affect steroid hormone metabolism in human breast cancer cells
British Journal of Clinical Pharmacology, EarlyView.Common genetic CYP2B6 variants correlate with adverse breast cancer outcome. The oestrogen metabolites estriol and 16‐epiestriol, which are formed downstream of CYP2B6‐catalysed 16α/β‐hydroxytestosterone, may be linked to elevated breast cancer risk and might increase due to the demonstrated CYP2B6 variants‐related metabolic shifts.
Marco Hoffmann +5 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective Topiramate has been linked to increased glaucoma risk, potentially through mechanisms involving ocular fluid shifts. However, comparative risks vs other antiseizure medications (ASMs) and variation by sex or indication remain uncertain.
Cuiling Wei +10 more
wiley +1 more source
PHARMACOEPIDEMIOLOGY: FROM THEORY TO PRACTICE
Фармакоэкономика, 2015 pharmacoepidemiology is a well recognized throughout the world scientific discipline studying the use of and the effects of drugs in the whole population or in large groups of people in order to improve efficacy and safety of pharmacotherapy. Despite its
S. A. Rachina +2 more
doaj
Cost-Effectiveness of Itopride Hydrochloride for the Treatment of Functional Dyspepsia in Vietnam
PharmacoepidemiologyBackground/Objectives: Functional dyspepsia is associated with abdominal pain and nausea, which leads to reduced quality of life, loss of productivity, and economic loss for patients.
Hansoo Kim +5 more
doaj +1 more source
Revista Brasileira de Epidemiologia, 2011 O presente artigo tem como objetivos propor e descrever a investigação em farmacoepidemiologia de campo como função primordial de farmacovigilância a ser conduzida pelas vigilâncias sanitárias municipais, estaduais e/ou federal frente à notificação ...
Daniel Marques Mota
doaj +1 more source
Pharmacoepidemiology, 2022 Unique aspects of New Zealand’s (NZ) health system allow for a novel pharmacoepidemiologic approach to conducting population-based clinical research. A defined cohort of surgical and trauma patients would facilitate future studies into opioid utilisation,
Jiayi Gong +5 more
doaj +1 more source
Ophthalmic adverse drug reactions to systemic drugs: a systematic review [PDF]
, 2014 PURPOSE: To perform a comprehensive and systematic review regarding ophthalmic adverse drug reactions (ADRs) to systemic drugs to: (i) systematically summarize existing evidence, (ii) identify areas, ophthalmic ADRs or drugs that lacked systematization ...
Azevedo, LF +3 more
core +1 more source
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Background Understanding the varied impact of COVID‐19 severity on pregnancy outcomes is crucial for informed clinical management and targeted interventions. Objective To evaluate the impact of COVID‐19 on pregnancy outcomes, distinguishing between pregnant women managed in primary care and those requiring hospitalization.
Odette de Bruin +73 more
wiley +1 more source