Results 81 to 90 of about 36,199 (325)

Pharmacology and safety of TAS5315, a Bruton tyrosine kinase inhibitor, in healthy volunteers: First‐in‐human, randomized, ascending‐dose studies

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim TAS5315 is a Bruton tyrosine kinase (Btk) inhibitor in development for autoimmune and allergic diseases, including rheumatoid arthritis (RA) and chronic spontaneous urticaria (CSU). Two clinical studies evaluated the pharmacology and safety of single and multiple oral doses of TAS5315.
Yuji Kumagai, Tomoe Fujita, Mika Maeda, Akiko Yamamoto, Hideki Amano   +4 more
wiley   +1 more source

Trends in gabapentinoid prescribing: A nationwide Danish drug utilization study

British Journal of Clinical Pharmacology, EarlyView.
Aims Pregabalin and gabapentin are increasingly used for pain and other conditions. Concerns exist about overuse as well as potential misuse and abuse. To guide rational prescribing practices, we provide detailed nationwide data on the use of gabapentinoids in Denmark.
Anton Pottegård, Lotte Rasmussen, Morten Olesen, Anne Mette Skov Sørensen, Zandra Nymand Ennis, Joseph Kane, Sarah Baxter, Blánaid Hicks   +7 more
wiley   +1 more source

The use of biomedicine, complementary and alternative medicine, and ethno-medicine for the treatment of epilepsy among people of South Asian origin in the UK [PDF]

, 2008
Studies have shown that a significant proportion of people with epilepsy use complementary and alternative medicine (CAM). CAM use is known to vary between different ethnic groups and cultural contexts; however, little attention has been devoted to inter-
Penny J Rhodes, Neil Small, Hanif Ismail, John P Wright, E Ernst, GS Han, P Tovey, R Dobson, JS Duncan, E Wirrell, V Ricotti, ES Roach, PL Pearl, J Scheller, K Easterford, JJ Sirven, LM DeBruyn, R Baskind, M Atadzhanov, A Millogo, U Seneviratne, Bradford District Council, J Wright, C Cummins, JY Nazroo, K Atkin, S Katbamna, H Ismail, H Ismail, N Small, P Rhodes, H Ismail, J Ritchie, R Barbour, J Pounceby, K Atkin, K Atkin, J Woodman, WIU Ahmad, M Tandon, K Saeed, LM Cf DeBruyn, P Desai, A Khan, J Cf Eade, SM Adib, CT Peebles, M Kelner, JA Astin, R Blais, GS Han, W Qidwai, M Tandon, Q Fazil, P Bywaters, G Mir, P Rhodes, P Rhodes, V Virmani, A Ghaffar, K Saeed, MH Cohen, D Cf Rao, E Ernst, E Ernst, E Ernst, NA Kshirsagar, N Luiz, G Mir, GM Foster, CL Briggs   +70 more
core   +2 more sources

The use of international classification of diseases codes to identify hospital admissions linked with adverse drug events: Validation study

British Journal of Clinical Pharmacology, EarlyView.
Aims Several methods exist to identify hospital admissions related to adverse drug events (ADEs). Clinical adjudication by healthcare professionals is the gold standard but is labour‐intensive. Spontaneous reporting and routinely collected healthcare data using a set of International Classification of Diseases (ICD) codes often underestimate the ...
Zuzana Juhásová, Fatma Karapinar‐Çarkit, Daniala L. Weir   +2 more
wiley   +1 more source

Association between benzodiazepine use and exacerbations and mortality in patients with asthma: a matched case-control and survival analysis using the United Kingdom Clinical Practice Research Datalink [PDF]

, 2015
Purpose: To investigate the association between the GABAergic drugs, benzodiazepines or zopiclone, and the occurrence of asthma exacerbations and subsequent mortality in a cohort of asthma patients. Methods: 105,747 patients without asthma exacerbation
Myles, Puja R., Nakafero, Georgina, Nguyen-Van-Tam, Jonathan S., Sanders, Robert D.   +3 more
core   +4 more sources

New‐user and prevalent‐user designs and the definition of study time origin in pharmacoepidemiology: A review of reporting practices

Pharmacoepidemiology and Drug Safety, 2021
Guidance reports for observational comparative effectiveness and drug safety research recommend implementing a new‐user design whenever possible, since it reduces the risk of selection bias in exposure effect estimation compared to a prevalent‐user ...
K. Luijken, Judith J Spekreijse, M. van Smeden, H. Gardarsdottir, R. Groenwold   +4 more
semanticscholar   +1 more source

Self-efficacy and medicine use for headache among adolescents in Italy: results from the Italian HBSC 2010 study [PDF]

, 2015
This article aims first to investigate gender patterns in medicine use, and corresponding headache complaints, in Italian adolescents; second, to examine the association between self-efficacy and medicine use for headache.
Cavallo, Franco, Marino, Claudia, Santinello, Massimo, Vieno, Alessio   +3 more
core   +1 more source

Impact of diclofenac risk minimization measures addressing cardiovascular risk on analgesic use in musculoskeletal disorders

British Journal of Clinical Pharmacology, EarlyView.
Aims In 2013, risk minimization measures (RMMs) were introduced in Europe to address the increased cardiovascular risk linked to diclofenac. This study aimed to assess the impact of those RMMs on analgesic use. Methods Primary care data from CPRD GOLD (UK) were used.
Tomas Lasys, Yared Santa‐Ana‐Tellez, Satu J. Siiskonen, Daniala L. Weir, Rolf H. H. Groenwold, Helga Gardarsdottir   +5 more
wiley   +1 more source

A Retrospective Review of COVID-19 Medicines Information Queries in a Quaternary Hospital with Unique COVID-19 Border Controls

Pharmacoepidemiology, 2023
Background: Medicines information (MI) is a specialist area of pharmacy that provides evidence-based answers to often complex medication queries, utilising resources such as textbooks and databases.
Jeanie Misko, Matthew D. M. Rawlins
doaj   +1 more source

Use of State Sequence Analysis in Pharmacoepidemiology: A Tutorial

International Journal of Environmental Research and Public Health, 2021
While state sequence analysis (SSA) has been long used in social sciences, its use in pharmacoepidemiology is still in its infancy. Indeed, this technique is relatively easy to use, and its intrinsic visual nature may help investigators to untangle the ...
J. Vanoli, C. Nava, C. Airoldi, A. Ucciero, V. Salvi, F. Barone-Adesi   +5 more
semanticscholar   +1 more source