Results 91 to 100 of about 27,665 (215)

Anaphylactic reactions after administration of etoposide followed by paclitaxel in a patient [PDF]

, 2014
Anafylactische reacties ten gevolge van chemotherapeutische medicatie komen soms voor en kunnen ernstig zijn. De diversiteit aan oorzaken maakt het optreden van een dergelijke overgevoeligheidsreactie moeilijk te voorspellen.
Pharmacoepidemiology, Tupker, R.A., Wiltink, E., van den Bogert, C.A., Pharmacoepidemiology and Clinical Pharmacology, Schramel, F.M.N.H., Vis, R., Sub Pharmacoepidemiology   +7 more
core  

Benefit-risk reassessment of medicines:: a retrospective analysis of all safety-related referral procedures in Europe during 2001-2012 [PDF]

, 2016
PURPOSE:The aim of this study was to determine the outcomes and timing within the product life cycle of all benefit-risk reassessment procedures for marketed products that were completed by the committee for medicinal product for human use during 2001 ...
Bouvy, J.C., Pharmacoepidemiology and Clinical Pharmacology, Huinink, I., de Bruin, M.L., Sub Pharmacoepidemiology   +4 more
core   +2 more sources

Use of selective serotonin reuptake inhibitors and risk of myeloid malignancy: A nationwide Danish case–control study

British Journal of Haematology, EarlyView.
Summary Preclinical and clinical studies suggest that selective serotonin reuptake inhibitors (SSRIs) can stimulate haematopoiesis by promoting proliferation and mobilization of haematopoietic stem and progenitor cells, but whether SSRI use influences myeloid malignancy risk remains unclear.
Katrine Mose, Anton Pottegård, Mette Reilev, Christen Lykkegaard Andersen, Blánaid Hicks, Mathilde Egelund Christensen   +5 more
wiley   +1 more source

Antibiotic Prescribing for Group B Streptococcus Coverage in Preterm Prelabour Rupture of Membranes: A Retrospective Cohort Study

Pharmacoepidemiology
Background: Preterm prelabour rupture of membranes (PPROM) is the spontaneous rupture of fetal membranes prior to 37 weeks of pregnancy. Latency antibiotics, including macrolides with or without group B streptococcus (GBS)-covering antibiotics, are ...
Elaf Abuelgasim, Mark McIntyre, Najla Tabbara   +2 more
doaj   +1 more source

Pharmacovigilance and pharmacoepidemiology

, 2001
Pharmacovigilance involves the detection of unexpected, and often undesirable, adverse effects of drugs. Pharmacoepidemiology, often considered a sub-domain in pharmacovigilance, attempts to quantify the frequency of these adverse effects, and to ...
De Vries, Corinne, De Jong-Van Den Berg, Lolkje   +1 more
core   +2 more sources

MCL‐1 inhibition triggers a largely reversible cardiac stress signature in a humanised mouse model

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Myeloid cell leukaemia‐1 (MCL‐1) is an essential anti‐apoptotic protein and a promising therapeutic target in oncology. Early clinical studies of MCL‐1 inhibitors reported unexpected elevations in cardiac troponin, raising concerns about potential cardiotoxicity.
Markus B. Heckmann, Zsanett Papdi, Nils J. Strauch, Daniel Finke, Marc‐Steffen Raab, Antje Blank, Norbert Frey, Lorenz H. Lehmann   +7 more
wiley   +1 more source

A Retrospective Analysis of the Clinical Effectiveness of Tigecycline in the Treatment of Clostridioides difficile-Associated Diarrhea

Pharmacoepidemiology
Clostridioides difficile infection (CDI) is the leading cause of nosocomial diarrhea in the United States. Tigecycline has been proposed as a potential treatment for CDI, though limited clinical data exist to support this practice.
Herman Joseph Johannesmeyer, Luiza Baloyan, Kristica Kolyouthapong   +2 more
doaj   +1 more source

Big data, pharmacoepidemiology and pharmacovigilance

, 2020
Big data is a term that comprises a group of technological tools capable of processing extremely large heterogeneous data sets, which are continuously collected and are available to be used at any time, and, therefore, constitutes a source of scientific ...
Gaviria-Mendoza, Andrés, Andrés Gaviria-Mendoza, Moreno Gutiérrez, Paula Andrea, Machado Alba, Jorge Enrique, Jorge Enrique Machado-Alba, Sánchez-Duque, Jorge A, Paula Andrea Moreno-Gutiérrez, Jorge Andrés Sánchez-Duque   +7 more
core   +1 more source

Signal detection and characterisation of a novel drug–drug interaction between methadone and a synthetic cannabinoid receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Little is known about how synthetic cannabinoid receptor agonist (SCRA) co‐use with other psychoactive substances may exacerbate risk of death. This study aimed to characterise the polypharmacy of deaths where SCRAs were detected at post‐mortem, investigate the cardiotoxicity of SCRAs and probe their inhibition of human ether‐a ...
Kirsten L. Rock, Louise M. Hesketh, Hongwei Cheng, Shuoqi Chen, Simon Hudson, Graeme Henderson, Jules C. Hancox, Michael J. Shattock, Michael J. Curtis, Caroline S. Copeland   +9 more
wiley   +1 more source

Adverse Drug Reactions in Multimorbid Older People Exposed to Polypharmacy: Epidemiology and Prevention

Pharmacoepidemiology
Adverse drug reactions (ADRs) are frequent and represent a significant healthcare burden. ADRs are a potentially avoidable contributor to excess unscheduled hospital admissions, higher morbidity, mortality, and healthcare costs.
Siobhán McGettigan, Denis Curtin, Denis O’Mahony   +2 more
doaj   +1 more source