Results 111 to 120 of about 35,320 (249)

Stronger instruments and refined covariate balance in an observational study of the effectiveness of prompt admission to intensive care units [PDF]

open access: yes, 2020
Instrumental variable methods, subject to appropriate identification assumptions, enable consistent estimation of causal effects in the presence of unobserved confounding. Near–far matching has been proposed as one analytic method to improve inference by
Grieve, R   +3 more
core   +1 more source

Treatment durability, satisfaction and quality of life in virologically suppressed HIV‐1 people switching to doravirine: Results from the French study DoraVIH

open access: yesHIV Medicine, EarlyView.
Abstract Objectives In Europe, most people with HIV‐1(PWH) achieve virologic suppression with effective and well‐tolerated antiretroviral therapies (ART). In this context, patient‐reported outcomes (PRO) are increasingly important for evaluating ART benefits.
Spire Bruno   +9 more
wiley   +1 more source

Perspectives of Older Patients on the Complexity of Medication Use

open access: yesJournal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Medication use complexity is associated with non‐adherence, hospitalizations, and lower quality of life. It is most frequently measured with the Medication Regimen Complexity Index (MRCI). This instrument estimates the complexity of a patient's medication regimen, taking into account the pharmaceutical dosage forms and routes ...
Charlotte M. Falke   +6 more
wiley   +1 more source

Characteristics of the Long‐Term Care Data Cooperative: A New Resource for Research on Outcomes in Long‐Term Care

open access: yesJournal of the American Geriatrics Society, EarlyView.
ABSTRACT Background The long‐term care (LTC) Data Cooperative is a National Institute on Aging‐funded data resource that links skilled nursing facility (SNF) electronic health record (EHR) data with Medicare and Medicaid claims for use in comparative effectiveness and interventional research.
Stephanie M. Kissam   +8 more
wiley   +1 more source

Conducting Medication Reviews: A Comparative Study Between ChatGPT‐4 and Healthcare Professionals

open access: yesJournal of the American Geriatrics Society, EarlyView.
ABSTRACT Background The increasing prevalence of patients with hyperpolypharmacy (> 10 medications) has made medication reviews increasingly complex. ChatGPT‐4‐Turbo (ChatGPT), a large language model, has demonstrated potential in healthcare applications and could potentially support medication reviews.
Simone M. K. ten Hoope   +5 more
wiley   +1 more source

Cost-Effectiveness of Itopride Hydrochloride for the Treatment of Functional Dyspepsia in Vietnam

open access: yesPharmacoepidemiology
Background/Objectives: Functional dyspepsia is associated with abdominal pain and nausea, which leads to reduced quality of life, loss of productivity, and economic loss for patients.
Hansoo Kim   +5 more
doaj   +1 more source

Evaluating Major Bleeding Risks with Concomitant Use of Direct Oral Anticoagulants and Selective Serotonin Reuptake Inhibitors in Nonvalvular Atrial Fibrillation Patients

open access: yesPharmacoepidemiology
Background/Objectives: Direct oral anticoagulants (DOACs), when compared to the Vitamin K antagonist (VKA) warfarin, exhibit greater safety and effectiveness.
Shu-Yu Yao   +3 more
doaj   +1 more source

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1522-1536, June 2026.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra   +4 more
wiley   +1 more source

Rescue Therapy for Supratherapeutic Concentrations of Calcineurin Inhibitors Using Potent Cytochrome P450 Inducers

open access: yesPharmacoepidemiology
Introduction: Calcineurin inhibitors (CNIs), ciclosporin and tacrolimus, are utilized primarily in organ transplantation and the treatment of autoimmune diseases.
Seth Duwor   +5 more
doaj   +1 more source

Building a Robust Investigator‐Initiated Platform: The I‐CARE Experience

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1537-1546, June 2026.
Investigator‐initiated studies that include information collected by patients are rising, but limited data is available on patient and investigator experience in this setting. The I‐CARE cohort included patients with inflammatory bowel disease (IBD) monthly collecting clinical information in 15 countries for up to 6 years.
Julien Kirchgesner   +906 more
wiley   +1 more source

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