Results 121 to 130 of about 35,320 (249)

Opioid Prescribing for Noncancer Patients—Issues of Drug Therapy Safety: Results from a German Study Based on Routine Data

Pharmacoepidemiology
Opioids are highly effective drugs but need close monitoring to avoid harm to patients. The aim of this study was to analyze how guideline recommendations are met for (i) the avoidance of the concomitant use of anxiolytics, hypnotics, or sedatives; (ii ...
Veronika Lappe, Daniel Grandt, Ursula Marschall, Ingrid Schubert   +3 more
doaj   +1 more source

Implementation of OMOP and ConcePTION Common Data Models in CPRD GOLD: Risk of Bleeding and Cardiovascular Outcomes From Anticoagulant Use

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1574-1583, June 2026.
The impact of the choice of common data model (CDM) approach on the study results in a real‐world evidence (RWE) study is unknown. We aimed to determine potential differences in the results of an RWE study when data were mapped to two different CDMs, ConcePTION and OMOP. With the same instance of CPRD GOLD, data were mapped to both CDMs. Using the same
Nicholas B. Hunt, Patrick Souverein, Marloes Bazelier, Nicola Barclay, Antonella Delmestri, Miriam Sturkenboom, Daniel Prieto‐Alhambra, Helga Gardarsdottir, Olaf Klungel   +8 more
wiley   +1 more source

Affordability of Paediatric Oral Anti-Infective Medicines in a Selected District, Sri Lanka

Pharmacoepidemiology
In this cross-sectional descriptive study conducted in the Ratnapura district, Sri Lanka, we assessed the affordability of oral pediatric anti-infective medicines (OPAIMs).
Malith Kumarasinghe, Manuj C. Weerasinghe   +1 more
doaj   +1 more source

The Prognostic Significance of Radiographic Progression Without PSA Progression in Patients With Metastatic Hormone‐Sensitive Prostate Cancer Treated With First‐Line ARPI Therapy

The Prostate, Volume 86, Issue 8, Page 882-890, June 2026.
ABSTRACT Background Radiographic progression (RP) without prostate‐specific antigen (PSA) elevation has emerged as a clinically important pattern in the androgen receptor pathway inhibitors (ARPI) era, but its prevalence and prognostic significance in real‐world metastatic hormone‐sensitive prostate cancer (mHSPC) cohorts remain unclear.
Takeshi Tsutsumi, Shogo Yamazaki, Takuya Matsuda, Takuya Tsujino, Taizo Uchimoto, Takafumi Yanagisawa, Keiichiro Mori, Wataru Fukuokaya, Fumihiko Urabe, Masanobu Saruta, Atsuhiko Yoshizawa, Shingo Toyoda, Saizo Fujimoto, Kyosuke Nishio, Moritoshi Sakamoto, Tatsuo Fukushima, Ko Nakamura, Kazuki Nishimura, Keita Nakamori, Tomohisa Matsunaga, Yuki Yoshikawa, Ryoichi Maenosono, Kiyoshi Takahara, Teruo Inamoto, Takahiro Kimura, Kazutoshi Fujita, Kazumasa Komura, Haruhito Azuma   +27 more
wiley   +1 more source

Storage, Disposal, and Misuse of Unused and Expired Pharmaceuticals in Households amongst Staff Working at Dakshinapaya Ministry Complex, Labuduwa, Galle Region: A Qualitative Phenomenological Study

Pharmacoepidemiology
(1) Background: Although Sri Lanka is a developing country and boasts of having a well-established healthcare system along with good healthcare indices, we are still lagging in certain aspects of healthcare.
Pramila G. Chandrasena, Sampath Gunawardena, Shanika V. Karunanayaka   +2 more
doaj   +1 more source

Methods Applied to Assess Real‐World Effectiveness of Drugs: A Scoping Review

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Drug effectiveness evaluations are needed to bridge the gap between premarketing trials and clinical practice, but the specific methods used in such evaluations remain unclear. Therefore, this review aimed to identify pharmacoepidemiological effectiveness studies based on real‐world data (RWD) and categorize them based on the methods applied ...
Benedikte Irene von Osmanski, Janne Petersen, Charlotte Thor Petersen, Andreas Høiberg Bentsen, Espen Jimenez‐Solem, Mikkel Zöllner Ankarfeldt   +5 more
wiley   +1 more source

Off-Label Use of Dalbavancin in Enterococcus spp. Abscess and Streptococcus pneumoniae Bacteremia Secondary to Septic Arthritis: A Retrospective Case Report

Pharmacoepidemiology
Dalbavancin, a semi-synthetic lipoglycopeptide with an extended half-life that allows for weekly dosing, is currently approved for the treatment of bacterial skin and soft tissue infections caused by susceptible gram-positive organisms.
Miriam Banoub Morkos, Giovani Leon, Mai-Chi Hong, Joshua Allan Garcia, Martin J. Breen, Bhanu Sud, Lee Nguyen   +6 more
doaj   +1 more source

Exposure to Systemic Antimicrobials During Pregnancy and Risk of Miscarriage: A Population‐Based Registry Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 7, Page 1394-1404, June 2026.
ABSTRACT Objective To estimate miscarriage risk following gestational antimicrobial exposure while addressing biases that have affected previous studies. Design Population‐based cohort study. Setting Linkage of four nationwide registries: Medical Birth Registry of Norway (MBRN), Norwegian Prescribed Drug Registry (NorPD), Norwegian Patient Registry ...
Thomas Boissiere‐O'Neill, Marleen M. H. J. van Gelder, Hilde M. Engjom, Hedvig M. E. Nordeng   +3 more
wiley   +1 more source

Benzodiazepine Adverse Reaction Cases Age 50 and Older Reported to the U.S. Poison Centers: Healthcare Use and Major Medical Effects

Pharmacoepidemiology
Background: Despite widespread consensus on the need to reduce benzodiazepine (BZD) use in older adults, prescription rates in the U.S. have paradoxically increased over the past few decades.
Bryan Y. Choi, Namkee G. Choi, C. Nathan Marti, S. David Baker   +3 more
doaj   +1 more source

Maternal Obesity, Gestational Diabetes Mellitus and Offspring's Body Mass Index Trajectories From Birth to Age 6 Years: Glucose in Relation to Women and Babies' Health (GrownB) Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 7, Page 1475-1483, June 2026.
ABSTRACT Objective To examine whether offspring born to mothers with overweight/obesity, gestational diabetes mellitus (GDM) or both exhibit different body mass index (BMI) trajectories from birth to 6 years old. Design Retrospective cohort study. Setting The Glucose in Relation to Women and Babies' Health (GrownB) Study at the University of California,
Cheng‐Tzu Hsieh, Xinyue Liu, Xiang Li, Rana F. Chehab, Yeyi Zhu, Liwei Chen   +5 more
wiley   +1 more source