Results 121 to 130 of about 25,921 (246)

Pharmacoepidemiology at Nordic School of Public Health NHV: Examples from 1999 to 2014

, 2015
Background: Pharmacoepidemiology is a branch of public health and had a place at the Nordic School of Public Health. Courses, Masters theses and Doctorates of Public Health (DrPH) in Pharmacoepidemiology were a relatively minor, but still important part ...
Hanna Gyllensten, Lundborg, C. S., Hakkarainen, K. M., Hakkarainen, Katja M.,, Lesen, E, Gyllensten, Hanna,, Gyllensten, H,, Stalsby Lundborg, Cecilia,, Lesen, Eva,, Hakkarainen, KM, Andersson Sundell, Karolina,, Sundell, KA, Katja M. Hakkarainen, Karolina Andersson Sundell, Lesen, E., Cecilia Stålsby Lundborg, Hedna, K., Hedna, K, Lundborg, CS, Khedidja Hedna, Eva Lesén, Hedna, Khadidja,   +21 more
core   +1 more source

Beyond PEGylation: Archaeal Lipids for Long‐Circulating Liposomes

Advanced NanoBiomed Research, Volume 6, Issue 6, June 2026.
Archaeal lipid‐based liposomes, particularly those containing caldarchaeol (GDGT), were found to significantly prolong the circulation time of vancomycin in rats, matching the pharmacokinetic properties of PEGylated systems. These findings suggest archaeal lipids as promising non‐PEG excipients for parenteral applications to minimize drug clearance ...
Viktor Sedlmayr, Andreas D. Meid, Eric Mühlberg, Manuel Ben Böhmann, Julian Quehenberger, David Wurm, Mikko Gynther, Oliver Spadiut, Gert Fricker, Philipp Uhl   +9 more
wiley   +1 more source

Rescue Therapy for Supratherapeutic Concentrations of Calcineurin Inhibitors Using Potent Cytochrome P450 Inducers

Pharmacoepidemiology
Introduction: Calcineurin inhibitors (CNIs), ciclosporin and tacrolimus, are utilized primarily in organ transplantation and the treatment of autoimmune diseases.
Seth Duwor, Katharina Enthofer, Christoph Ganter, Prabin Poudel, Anna Svarin, Gerd A. Kullak-Ublick   +5 more
doaj   +1 more source

Potential misinterpretation of treatment effects due to use of odds ratios and logistic regression in randomized controlled trials.

, 2011
Background In randomized controlled trials (RCTs), the odds ratio (OR) can substantially overestimate the risk ratio (RR) if the incidence of the outcome is over 10%.
Pharmacoepidemiology, Duijnhoven, R.G., Groenwold, R.H.H., Knol, M.J., Grobbee, D.E., Moons, K.G.M., Sub Pharmacoepidemiology   +6 more
core   +1 more source

Population pharmacokinetic modelling of amoxicillin in human breast milk—A contribution from the ConcePTION project

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1833-1844, June 2026.
Aims Amoxicillin, a widely used β‐lactam antibiotic, requires improved pharmacokinetic characterization during breastfeeding. This study used a population pharmacokinetic (PopPK) approach to model amoxicillin concentrations in breast milk, identify variability sources and estimate infant exposure, applying worst‐case scenarios.
Sarah Baklouti, Virginie Rigourd, Alice Panchaud, Hedvig Nordeng, Karel Allegaert, Pieter Annaert, Miao‐Chan Huang, Anaelle Monfort, Monia Guidi, Peggy Gandia   +9 more
wiley   +1 more source

Opioid Prescribing for Noncancer Patients—Issues of Drug Therapy Safety: Results from a German Study Based on Routine Data

Pharmacoepidemiology
Opioids are highly effective drugs but need close monitoring to avoid harm to patients. The aim of this study was to analyze how guideline recommendations are met for (i) the avoidance of the concomitant use of anxiolytics, hypnotics, or sedatives; (ii ...
Veronika Lappe, Daniel Grandt, Ursula Marschall, Ingrid Schubert   +3 more
doaj   +1 more source

Measuring Medication Related Harm: Proposed Guidance for Adverse Drug Event Adjudication to Harmonize Outcomes in Deprescribing Research

Journal of the American Geriatrics Society, EarlyView.
Sydney B. Ross, Émilie Bortolussi‐Courval, Zuzana Juhásová, Daniala L. Weir, Allison Goodwin Wilson, Todd C. Lee, Emily G. McDonald, Marnie Goodwin Wilson   +7 more
wiley   +1 more source

Affordability of Paediatric Oral Anti-Infective Medicines in a Selected District, Sri Lanka

Pharmacoepidemiology
In this cross-sectional descriptive study conducted in the Ratnapura district, Sri Lanka, we assessed the affordability of oral pediatric anti-infective medicines (OPAIMs).
Malith Kumarasinghe, Manuj C. Weerasinghe   +1 more
doaj   +1 more source

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1522-1536, June 2026.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra, Viktoriia Starokozhko, Elisabeth Bakker, Anna Maria Gerdina Pasmooij, Peter Gerardus Maria Mol   +4 more
wiley   +1 more source

Storage, Disposal, and Misuse of Unused and Expired Pharmaceuticals in Households amongst Staff Working at Dakshinapaya Ministry Complex, Labuduwa, Galle Region: A Qualitative Phenomenological Study

Pharmacoepidemiology
(1) Background: Although Sri Lanka is a developing country and boasts of having a well-established healthcare system along with good healthcare indices, we are still lagging in certain aspects of healthcare.
Pramila G. Chandrasena, Sampath Gunawardena, Shanika V. Karunanayaka   +2 more
doaj   +1 more source