Results 91 to 100 of about 52,343 (282)

Efficacy and safety of low‐dose atorvastatin plus ezetimibe for primary hypercholesterolemia: A randomized, double‐blind, multicenter phase 3 trial

Lipids, EarlyView.
Low‐dose atorvastatin combined with ezetimibe achieves superior LDL‐C reduction (44.8%) compared with equivalent or higher‐dose statin monotherapy in Korean patients, presenting a more effective and safer therapeutic strategy potentially applicable to broader Asian populations.
Tae Oh Kim, Kyounghoon Lee, Jin‐Man Cho, Hyuck‐Jun Yoon, Tae‐Ho Park, Jung Hyun Choi, Jung‐Won Suh, Seok‐Yeon Kim, Hong‐Seok Lim, Jong‐Seon Park, Deok‐Kyu Cho, Gyung‐Min Park, Sung‐Gyun Ahn, Sanghoon Shin, Sung Uk Kwon, Dae‐Hyeok Kim, Sang‐Rok Lee, Jung‐Hoon Sung, Hwan‐Cheol Park, Seung‐Whan Lee   +19 more
wiley   +1 more source

Advancing the science of genomic learning healthcare systems

Learning Health Systems, EarlyView.
Abstract Introduction Identifying key characteristics of exemplar genomic learning healthcare systems (gLHS) and knowledge gaps that can be explored by collaboration among them is likely to accelerate the sharing of best practices and generation of evidence that informs the use of genomics in clinical care.
Teri A. Manolio, Renee Rider, Carol J. Bult, Rex L. Chisholm, Patricia A. Deverka, Geoffrey S. Ginsburg, Eric D. Green, Gail P. Jarvik, George A. Mensah, Jahnavi Narula, Erin M. Ramos, Mary V. Relling, Dan M. Roden, Robb Rowley, Noura S. Abul‐Husn, Adam H. Buchanan, Christopher G. Chute, Guilherme Del Fiol, Gai Elhanan, Susanne B. Haga, Rizwan Hamid, Carol R. Horowitz, Peter J. Hulick, Cynthia A. James, Janina M. Jeff, Bruce Korf, Latrice Landry, Deven McGraw, Howard L. McLeod, Nancy J. Mendelsohn, Travis Osterman, Casey Overby Taylor, Daryl Pritchard, Heidi L. Rehm, Krystal S. Tsosie, Jason L. Vassy, Karriem Watson, Ken Wiley Jr, Marc S. Williams   +38 more
wiley   +1 more source

Pharmacogenetics and Stroke [PDF]

Stroke, 2009
Genetic variations have been shown to influence drug metabolism, risk of adverse drug events, and pharmacodynamic responses for many drugs routinely used to treat patients with stroke or at risk for stroke. Examples include clopidogrel, statins, antihypertensive medications, and coumadin.
openaire   +3 more sources

Development and Verification of Virtual Population Models for Predicting Drug Pharmacokinetics in Ethnic North American Populations

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Ethnic variabilities can affect the outcome of drug pharmacokinetics (PK) and drug–drug interactions (DDI). This work aimed to develop four North American (NA) sub‐populations: White, African American, Asian American, and Hispanic_Latino suitable for physiologically based pharmacokinetic (PBPK) modeling and simulations.
Udoamaka Ezuruike, Jean Dinh, Eman El‐Khateeb, Alex Blenkinsop, Oliver Hatley, Iain Gardner   +5 more
wiley   +1 more source

Neural circuitry of rapid eye movement sleep homeostasis: Mechanistic insights and pathological implications

Sleep Research, EarlyView.
Abstract Rapid eye movement (REM) sleep is a unique brain state crucial for emotion, memory, and plasticity. Unlike well‐understood non‐REM (NREM) sleep homeostasis, REM sleep homeostasis remains less clearly defined. This review highlights recent progress in understanding REM sleep homeostasis, focusing on its neurophysiological markers, neural ...
Ting He
wiley   +1 more source

Transgenic overexpression of steroid sulfatase alleviates cholestasis

Liver Research, 2017
Background and Aim: Sulfotransferase (SULT)-mediated sulfation and steroid sulfatase (STS)-mediated desulfation represent two critical mechanisms that regulate the chemical and functional homeostasis of endogenous and exogenous molecules.
Mengxi Jiang, Meishu Xu, Songrong Ren, Kyle W. Selcer, Wen Xie   +4 more
doaj   +1 more source

Clinical pharmacokinetics and pharmacogenetics of tamoxifen and endoxifen

Expert Review of Clinical Pharmacology, 2019
Introduction: Tamoxifen dominates the anti-estrogenic therapy in the early and metastatic breast cancer setting. Tamoxifen has a complex metabolism, being mainly metabolized by CYP2D6 into its 30–100 times more potent metabolite, endoxifen.
A. Sanchez-Spitman, J. Swen, V. Dezentjé, D. Moes, H. Gelderblom, H. Guchelaar   +5 more
semanticscholar   +1 more source

Exposure to Systemic Antimicrobials During Pregnancy and Risk of Miscarriage: A Population‐Based Registry Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To estimate miscarriage risk following gestational antimicrobial exposure while addressing biases that have affected previous studies. Design Population‐based cohort study. Setting Linkage of four nationwide registries: Medical Birth Registry of Norway (MBRN), Norwegian Prescribed Drug Registry (NorPD), Norwegian Patient Registry ...
Thomas Boissiere‐O'Neill, Marleen M. H. J. van Gelder, Hilde M. Engjom, Hedvig M. E. Nordeng   +3 more
wiley   +1 more source

Rational development of gemcitabine-based nanoplatform for targeting SERPINB9/Granzyme B axis to overcome chemo-immune-resistance

Nature Communications
SERPINB9, an endogenous inhibitor of granzyme B (GzmB), has emerged as a critical factor in the resistance to immunotherapy by protecting cancer cells from GzmB-induced cytotoxicity. However, its role in chemosensitivity remains unknown.
Haozhe Huang, Yiqing Mu, Yixian Huang, Beihong Ji, Yifei Wang, Chien-Yu Chen, Yuang Chen, Zhangyi Luo, Sihan Li, Ziqian Zhang, Luxuan Wang, James F. Conway, Da Yang, Junmei Wang, Jingjing Sun, Song Li   +15 more
doaj   +1 more source

Pharmacogenetics of follicle‐stimulating hormone action in the male

Andrology, EarlyView.
Abstract Male factor infertility (MFI) is involved in half of the cases of couple infertility. The follicle‐stimulating hormone (FSH) therapy is considered efficient to improve semen parameters and pregnancy rate in patients with idiopathic MFI, following the lesson learned from hypogonadotropic hypogonadism.
Andrea Graziani, Giuseppe Grande, Raffele Scafa, Riccardo Selice, Andrea Garolla, Maria Santa Rocca, Cinzia Vinanzi, Alberto Ferlin   +7 more
wiley   +1 more source